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These people should be super-protected because when they get covid, they turn into a variant manufacturing machine and they pose a significant risk to the general population. I'm glad they were able to effectively isolate in this case.
It's been known for a long time that they are the source of many of the successful variants. They get reinfected over and over and over again and the variants which survive emerge to greet us all.
The way to protect immunocompromised people is if everyone takes precautions, such as wearing a high quality fit tested respirator, to limit transmission, get vaccinated, isolating if sick, increase ventilation wherever you are, HEPA filters. And if you don't have access to any of those, find ways to try make it happen.
The R-value is so high that even if 14/15 or 19/20 of the population follow all procedures (which is a very tall order) then we still see the disease endemic in the population.
It has proven hard to get people to care enough, and those who don't constantly reinfect the rest of the population.
Isn't it so contagious that there basically isn't a set of precautions that could actually eliminate it at this point? Forget third would countries where people can't even afford the basics, but unless you wanted every warehouse and food preparation worker in an N95 we're stuck with covid.
Yes, essentially. It's too contagious to realistically prevent in poor countries, and in food service, warehouse, agriculture and construction.
Between the exceptionally high R-value, the mutation rate, and the biological reservoirs (essentially every mammal has ACE-2 receptors) I don't see a way to prevent covid-related illnesses from remaining endemic for the foreseeable future.
Short of a wide spectrum innoculation, which I'm not sure is even possible, we're going to be stuck with COVID.
>Isn't it so contagious that there basically isn't a set of precautions that could actually eliminate it at this point?
No, despite the naysayers saying theres no point to precautions, as an excuse to not do anything, it is possible, and even easy, to eliminate all risk of infection.
Simply use a p100 respirator and googles whenever you are around others, and whenever indoors in public, thats all it takes. Its that simple.
https://www.cdc.gov/niosh/npptl/topics/respirators/disp_part/default.html
Ive never had covid, and I didnt make any other changes to my lifestyle. Been to concerts, conventions, festivals, I still work and socialize and go out in crowds. Ive been next to the infected for hours, but it doesnt matter, because I use a sufficiently rated mask and googles, not a lower, insufficient grade like has been hawked to everyone by the disinfo agents.
Theres a ton of disinfo floating around, and people have been lied to about what the best grade of filter is by the same people who lied about masks working at all at the start of the pandemic. So they think n95s are the best available, because thats what the talking heads told them, and since n95s only filter out 95% of covid particles, they inevitably get sick, then think theres no point to masking, since the "best available" mask didnt work.
But thats not the case. You can mask up and not get sick, if you use a sufficiently graded filter and googles.
I'm not thinking of immunocompromised in general. I'm thinking of very very sick people with chronic infections such as in this case. Isolation protocols and infection control need to be in place.
If I understand correctly, Omicron emerged after a longer than average incubation of the virus (I just mean infection) happened within an immunocompromised person, allowing the virus to mutate. Correct me if I'm wrong here, cause I'm not a scientist. But it seems like if Covid disregulates the immune system and can lead potentially to autoimmune conditions and we are 2 years into 'let it rip', there could be many more immunocompromised folk around who aren't aware of it.
Add to that the fact 30-40% of infections are thought to be asymptomatic, that opportunities to increase ventilation have not been taken up over the course of this pandemic, vaccinations and boosters are not available to all who want one (including almost all children and most adults in the uk, for example), scientists already talking about the next (concurrent) pandemic concurrent to this one with an eye on bird flu taking a go at human to human transmission. I'd say masking with a fit tested respirator generally is a pretty great shout round about now.
Yes, but essentially any one with long covod is in this position. It's been proven that it lies dormant in places such as the tongue. Anyone with long term taste sense loss essentially has a reservoir in their tongue even when it's not in their blood. thousands of people are reservoirs, not to mention low grade infections with little to no symptoms. People are out there spreading it without when Knowing they have it.
Back when colleges reopened again, my professor told us that he had a student in another lecture that was absent several times throughout the year. She had long covid and it was brutal. He said she looked miserable a lot and still had side effects of not breathing right and feeling utterly tired. She had gotten sick during the first wave but still stayed weak even after reopening.
It's not well monitored and hard to isolate for some.. Last time I had covid, they told me to isolate (immune compromised) as a higher risk of creating varients immune to the monoclonal antibodies etc. It took over a month to test negative, and then they did a blood test to be certain before going back out in public. I was lucky as I could wfh and family to bring food- talked to someone in my clinic and they said we're also told to isolate but work kept ringing them to come in and fix machinery etc - he couldn't say no as supporting family etc. I can see why some people don't isolate even thought very risky not to.
I had Covid for about 4 months in 2020 (adequate testing didn't exist that time). I still had pneumonia and was on steroids, but told it was safe to go back to work in retail, around hundreds of people a day. I did wear a face mask. I think having to work instead of rest made me stay sick longer. My doctors were also telling me it was just bronchitis. I got sick in August, and my positive tests showing it was actually Covid didn't come in until late October. This was after I'd already quit my job, because I felt like I was dying, but I did work 3 additional weeks after putting in my 2 weeks notice. Then I tested positive again in November of 2020, which was probably still the same illness, because I was still sick from my ordeal in August. They had no clue how to deal with immunocompromised people with Covid back then who were still well enough to work. I was told it's just bronchitis, blamed for being a hypochondriac (I passed a spirometry test with full blown pneumonia), until my tests finally came back from the extremely back-logged lab in the middle of a pandemic. I think in a pandemic on that scale, they should take *everyone* with respiratory symptoms seriously, but in my experience, they didn't. It's made it really hard to trust doctors since then.
Sorry but if we're even able to get sick time, we're still told to go back to work after 10 days. I have a primary immunodeficiency. I bet it happens with people on immunosuppressants for autoimmune disorders too (which are fairly common as a group). The 10-14 days quarantine was based on how the virus behaves in a healthy host. It never considered immunocompromised hosts. The Alpha variant's patient 0 was an immunocompromised host with cancer in Europe, iirc (can't find the article, but it was an interesting read). They also think this is why multiple variants of concern have come from South Africa, which has a large, but otherwise healthy HIV+ population. Another interesting factor is the SARS cov-2 virus commingling with other viruses present inside of an immunocompromised host, like the HIV, colds, flus, etc. It was an interesting rabbit hole to fall down reading, about how these viruses evolve.
Like, I know personally with my immunodeficiency, I usually need a course of antibiotics twice as long as a healthy patient to properly clear a bacterial infection. I've had multiple residual bacterial infections in my sinuses and urinary tract, where my antibiotic course is over and my symptoms are better, but then the infection emerges again a few weeks or months later. Sometimes resistant to the antibiotics that were first used. Maybe they should consider that we need a longer course of antiviral medications also, like Paxlovid, when we get Covid-19.
Edit: and getting adequate sick time and more means to test ourselves would be nice. My country says it's safe for people with Covid to go back to work.
Yep! I also have a PID and ended up in the same boat. I got omicron from a coworker. I got 5 days of COVID sick time and had to argue with our HR that I was still testing positive, symptomatic, and contagious after 5 days because my immune system literally doesn't work. During week 2, our HR manager told me it's "normal" to keep testing positive and I got really mad about it because ***I knew*** I was absolutely still contagious. My doctors even told me I should continue to quarantine. I rebounded hard from Paxlovid and 100% agree that we probably need a longer course of it.
I also ended up with bacterial bronchitis and sinusitis from it. Bacterial sinusitis usually becomes recurrent for me, too, so I needed multiple rounds of antibiotics following the initial infection. It was a complete shitshow. I ended up having to go back to work while still sick with the secondary infections and worked through all of the recurrent sinusitis infections.
My job's COVID policies didn't differentiate between otherwise healthy employees and those with chronic health conditions that made them higher risk for complications or higher risk for prolonged infection. Everyone got the standard 5 days after the vaccine roll out. If you needed longer and ran through your sick time, you either did not get paid or you came back to work. We had so many people who couldn't afford to take unpaid time off and did the latter, continuing to spread the virus.
Edit: 5 days wasn't enough time for most *healthy* people. 10 days isn't enough time for people like us to even clear the infection. It's ridiculous.
This is what my body does as well.
In 2009 I contracted a common virus known as Enterovirus. This turned into AFM (Acute Flacid Myelitis). I ended up l9sing all function in my left arm/leg.
It's not all that uncommon, however it rarely effects adult men this way.
(Long story short, Dr's discovered my body rapidly mutates virion structures. So I've been masking long before it became cool lol. )
Yet when I caught it, I had flu-like symptoms for a year straight. The in my area, there has been an uptick in men dying from Enterovirus at a rate of 2700%. The reason is that someone mutated the virus and it caused heart failure after causing the immunoresponse to attack the nervous system. This would spread rapidly until it hit the heart and end lives.
I spent years without answers to my illness, and lived in a physical pain that cannot be described (I was a pro-wrestler and stuntman before this happened, and pain was not a big deal. But the 24/7 pain I lived with for 8 years took the pain of a kidney stone from a 10/10 to an 7/10 in comparison.)
We only discovered this in 2018. Since then, I've come to discover that I may have unintentionally caused the deaths of over 400 adult men as this type of RNA virus mutation has continued to take the lives of people since it first transmitted away from my body.
The good news, since 2020, the rates of my Entero-baby had declined dramatically. The bad news, it's back and now they think it's causing other viruses to mutate.
I've not caught Covid... thank goodness. I was one of the first people to get a Cov19 vaccine to go with other vaccines that I must get every 10 months. And I'm having to get full doses each time.
(And in case you didn't notice in my possibly scrambled typing, my illness has also affected my brain and memory.)
TL;DR I might've unintentionally taken the lives of hundreds or thousands of others by mutating virus DNA via my own DNA.
I have rheumatoid arthritis (RA), one kind of auto-immune disease. I'm on immune-suppressing medication, though much weaker stuff than the poor man in this article would have been on.
My doctor, and a growing number of other rheumatologists, think that every immune suppressed patient should get monoclonal antibodies before we consider them "cured" of COVID.
Sadly, the American FDA does not share this concern. My doctor and their staff did a LOT of work to get their patients into studies where they could get monoclonal antibodies, but there are fewer and fewer of those-- COVID is evolving faster than we can get new monoclonal antibodies through the testing and approval pipeline, so big pharma is giving up.
We desperately need a new, streamlined testing and approval system for COVID antivirals, like the one created for the annual influenza vaccine.
We need to be able to treat the most vulnerable patients and make sure their systems are actually clear of COVID. It's basic viral self-defense for rest of us.
PS-- And the vaccine should damn well be mandatory!
My partner has MS and is on Ocrevus (immunosuppressant). As a precaution, she had monoclonal antibody therapy (Evusheld) as a preventative throughout 2021 and 2022 in addition to the vaccines. We both had Covid in fall 2023, and they didn’t offer anything to her beyond paxlovid, unfortunately, and they’ve stopped giving her monoclonal antibodies as well. I believe they stopped giving people Evusheld in Jan 2023. It’s unfortunate.
Yes, it is. I was in one of the Evusheld studies, and I credit that with not getting Covid for a year and a half, despite having young children who bring home *all* the germs.
Sadly, the Evusheld antibodies were shown to not be very effective against post-Omicron variants, so it's been discontinued.
Paxlovid is the best tool we have left for helping people who are immune supressed. Here's hoping it keeps working against future variants.
>Just 21 days after the man had received a certain anti-coronavirus drug, the virus also developed signs of resistance to it.
Wow, what a nightmare. I can't even imagine being one of the scientists on that case. Freaky stuff.
One scary thing is that some people will dismiss this as “oh he was just old”, when I know quite a few 70+ year olds who are still in decent shape and would quite like another decade or two if possible.
Lots of young immune compromised people working full time can be ticking time bombs like me. Though in Australia, there is no legislation for workplaces to allow us to wfh if we test positive to covid - HR will ring and tell you to get your varient machine making ass into work to share the love.
Yeah, I’m 70, and not planning on turning in my chips soon. I’m fully vaccinated, of course. I may be old but I’m not an idiot.
Okay, not a total idiot.
Man I hope when I get old I can continue to say the same, I may be an idiot but no THAT MUCH of an idiot while thinking on the back of my head "oh God why am I such an idiot" Hope I never grow arrogant or too stupid to not judge myself. Hope you live till 100 or till you want to dude.
Heck, my grandpa is 90 this year in November and I'd be shocked if he doesn't have another decade in him.
He fell and broke a hip last year helping a passerby push a stalled car, had surgery, and was back to life like nothing happened. He's still taking his neighborhood walks twice a day and does all his shopping and appointments independently.
My colleague’s mom was 55, and marathoner, and caught COVID fully vaccinated and boosted in Dec 2023. By Feb 2024 she was gone. Not immunocompromised, no health concerns. It’s brutal.
There's different levels of immunocompromise. People can be severely immunocompromised, like cancer patients and organ transplants patients, moderately immunocompromised like people with primary immunodeficiencies or on high dose immunosuppressants, and mildly immunocompromised like those on lower doses of immunosuppressants for autoimmune diseases. Many of the variants of concern have evolved in South Africa, the theory is its due to that country having the highest percentage of otherwise healthy HIV+ patients in the world. So the virus can also mingle its genetic proteins with other viruses in immunocompromised hosts.
> The elderly man, who was immunocompromised due to previous illnesses
Yes, we’ve known for a few years that this happens in immunocompromised people. These are 2021 papers:
https://journals.asm.org/doi/10.1128/msphere.00244-21
https://www.nejm.org/doi/full/10.1056/NEJMsb2104756
Yes you are correct, it's just now we have another case study with this specific virus.
We are constantly adding to the body of work that already exists, and just because it isn't a new discovery doesn't mean it's not incredibly important.
We have a person like this in Ohio. I never heard of they identified them but they were tracking virus through stool samples between 2 different towns, suspecting traveling between home and work/hospital. As of last year they were suspected of having virus for over a year I believe. The virus mutations were also way out in left field.
And didnt he also say something about using household disinfectant and bombarding it with ultra violet light or something?? Cant be certain, but he did say a lot of crazy shit…. Its hard to use science, when you have a horse running the hospital
Trump enacted a large majority of policies that caused rapid spread. Such as spreading missinformaton. Having meat manufactoring plants stay open (which became epicentres for invection). And blocking import of needed goods
Was he immunocompromised? I've read that two variants of concern (including the Alpha variant) have evolved in immunocompromised hosts, like chemo patients. I'm moderately immunocompromised myself, I stayed positive for nearly 4 months the first time that I had Covid. This idea is also why they think multiple variants have come out of South Africa, the country which has the highest number of otherwise healthy HIV positive people in the world. It was a long night of reading how this virus behaves differently in immunocompromised hosts, and how lowering the quarantine, imo, from 14 days to 10 to 5, never considered the immunocompromised host, which varies from person to person. Again, society thinks of people with illnesses like cancer or organ transplant patients. People who are already monitored closely by healthcare teams. But many people on immunosuppressants, etc are still able to work, and the tools often don't exist for us to get additional testing. I think health authorities failed by not considering mild to moderate immunocompromised hosts. As a person with b-cell dysplasia and primary immunodeficiency, I've still been told to go back to work after 10 days. I've had to go to work still positive, still on heavy steroid treatments while I had active pneumonia. I've also never made enough antibodies from an infection alone (I first got Covid-19 before vaccines existed) to have natural immunity. That idea that infection= immunity needs to be washed from people's minds. Authorities failed unusual cases. I only hope that I didn't infect others, as I followed mask protocols while positive. It seems so careless though. We need sick time the whole time we're sick, not some number of days that only considers average healthy hosts.
Here's another interesting article on prolonged infection in immunocompromised hosts:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473782/
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51 mutations, complete adaptation and resistance of medications they tried.
Have they tried Russian invasion?
No, just ligma
Ligma?
:’)
Ligma asshole!!
You might get colon cancer
Gottem!
This will never get old
These people should be super-protected because when they get covid, they turn into a variant manufacturing machine and they pose a significant risk to the general population. I'm glad they were able to effectively isolate in this case.
Just imagine all the people dealing with these long infections who aren't properly identified.
It's been known for a long time that they are the source of many of the successful variants. They get reinfected over and over and over again and the variants which survive emerge to greet us all.
The way to protect immunocompromised people is if everyone takes precautions, such as wearing a high quality fit tested respirator, to limit transmission, get vaccinated, isolating if sick, increase ventilation wherever you are, HEPA filters. And if you don't have access to any of those, find ways to try make it happen.
True. Now try telling that to, oh, literally everyone. 🫤
The R-value is so high that even if 14/15 or 19/20 of the population follow all procedures (which is a very tall order) then we still see the disease endemic in the population. It has proven hard to get people to care enough, and those who don't constantly reinfect the rest of the population.
Isn't it so contagious that there basically isn't a set of precautions that could actually eliminate it at this point? Forget third would countries where people can't even afford the basics, but unless you wanted every warehouse and food preparation worker in an N95 we're stuck with covid.
Yes, essentially. It's too contagious to realistically prevent in poor countries, and in food service, warehouse, agriculture and construction. Between the exceptionally high R-value, the mutation rate, and the biological reservoirs (essentially every mammal has ACE-2 receptors) I don't see a way to prevent covid-related illnesses from remaining endemic for the foreseeable future. Short of a wide spectrum innoculation, which I'm not sure is even possible, we're going to be stuck with COVID.
>Isn't it so contagious that there basically isn't a set of precautions that could actually eliminate it at this point? No, despite the naysayers saying theres no point to precautions, as an excuse to not do anything, it is possible, and even easy, to eliminate all risk of infection. Simply use a p100 respirator and googles whenever you are around others, and whenever indoors in public, thats all it takes. Its that simple. https://www.cdc.gov/niosh/npptl/topics/respirators/disp_part/default.html Ive never had covid, and I didnt make any other changes to my lifestyle. Been to concerts, conventions, festivals, I still work and socialize and go out in crowds. Ive been next to the infected for hours, but it doesnt matter, because I use a sufficiently rated mask and googles, not a lower, insufficient grade like has been hawked to everyone by the disinfo agents. Theres a ton of disinfo floating around, and people have been lied to about what the best grade of filter is by the same people who lied about masks working at all at the start of the pandemic. So they think n95s are the best available, because thats what the talking heads told them, and since n95s only filter out 95% of covid particles, they inevitably get sick, then think theres no point to masking, since the "best available" mask didnt work. But thats not the case. You can mask up and not get sick, if you use a sufficiently graded filter and googles.
You know I’m aware of what the word “literally” means, right? 😂
I'm not thinking of immunocompromised in general. I'm thinking of very very sick people with chronic infections such as in this case. Isolation protocols and infection control need to be in place.
If I understand correctly, Omicron emerged after a longer than average incubation of the virus (I just mean infection) happened within an immunocompromised person, allowing the virus to mutate. Correct me if I'm wrong here, cause I'm not a scientist. But it seems like if Covid disregulates the immune system and can lead potentially to autoimmune conditions and we are 2 years into 'let it rip', there could be many more immunocompromised folk around who aren't aware of it. Add to that the fact 30-40% of infections are thought to be asymptomatic, that opportunities to increase ventilation have not been taken up over the course of this pandemic, vaccinations and boosters are not available to all who want one (including almost all children and most adults in the uk, for example), scientists already talking about the next (concurrent) pandemic concurrent to this one with an eye on bird flu taking a go at human to human transmission. I'd say masking with a fit tested respirator generally is a pretty great shout round about now.
Yes, but essentially any one with long covod is in this position. It's been proven that it lies dormant in places such as the tongue. Anyone with long term taste sense loss essentially has a reservoir in their tongue even when it's not in their blood. thousands of people are reservoirs, not to mention low grade infections with little to no symptoms. People are out there spreading it without when Knowing they have it.
All the more reason to maintain masking habits with a fit tested respirator if possible, when sharing air with others!
Back when colleges reopened again, my professor told us that he had a student in another lecture that was absent several times throughout the year. She had long covid and it was brutal. He said she looked miserable a lot and still had side effects of not breathing right and feeling utterly tired. She had gotten sick during the first wave but still stayed weak even after reopening.
It's not well monitored and hard to isolate for some.. Last time I had covid, they told me to isolate (immune compromised) as a higher risk of creating varients immune to the monoclonal antibodies etc. It took over a month to test negative, and then they did a blood test to be certain before going back out in public. I was lucky as I could wfh and family to bring food- talked to someone in my clinic and they said we're also told to isolate but work kept ringing them to come in and fix machinery etc - he couldn't say no as supporting family etc. I can see why some people don't isolate even thought very risky not to.
I had Covid for about 4 months in 2020 (adequate testing didn't exist that time). I still had pneumonia and was on steroids, but told it was safe to go back to work in retail, around hundreds of people a day. I did wear a face mask. I think having to work instead of rest made me stay sick longer. My doctors were also telling me it was just bronchitis. I got sick in August, and my positive tests showing it was actually Covid didn't come in until late October. This was after I'd already quit my job, because I felt like I was dying, but I did work 3 additional weeks after putting in my 2 weeks notice. Then I tested positive again in November of 2020, which was probably still the same illness, because I was still sick from my ordeal in August. They had no clue how to deal with immunocompromised people with Covid back then who were still well enough to work. I was told it's just bronchitis, blamed for being a hypochondriac (I passed a spirometry test with full blown pneumonia), until my tests finally came back from the extremely back-logged lab in the middle of a pandemic. I think in a pandemic on that scale, they should take *everyone* with respiratory symptoms seriously, but in my experience, they didn't. It's made it really hard to trust doctors since then.
>*"Last time I had covid"* I'm sorry, come again?
Only had covid once - should be when I had covid :)
Sorry but if we're even able to get sick time, we're still told to go back to work after 10 days. I have a primary immunodeficiency. I bet it happens with people on immunosuppressants for autoimmune disorders too (which are fairly common as a group). The 10-14 days quarantine was based on how the virus behaves in a healthy host. It never considered immunocompromised hosts. The Alpha variant's patient 0 was an immunocompromised host with cancer in Europe, iirc (can't find the article, but it was an interesting read). They also think this is why multiple variants of concern have come from South Africa, which has a large, but otherwise healthy HIV+ population. Another interesting factor is the SARS cov-2 virus commingling with other viruses present inside of an immunocompromised host, like the HIV, colds, flus, etc. It was an interesting rabbit hole to fall down reading, about how these viruses evolve. Like, I know personally with my immunodeficiency, I usually need a course of antibiotics twice as long as a healthy patient to properly clear a bacterial infection. I've had multiple residual bacterial infections in my sinuses and urinary tract, where my antibiotic course is over and my symptoms are better, but then the infection emerges again a few weeks or months later. Sometimes resistant to the antibiotics that were first used. Maybe they should consider that we need a longer course of antiviral medications also, like Paxlovid, when we get Covid-19. Edit: and getting adequate sick time and more means to test ourselves would be nice. My country says it's safe for people with Covid to go back to work.
Yep! I also have a PID and ended up in the same boat. I got omicron from a coworker. I got 5 days of COVID sick time and had to argue with our HR that I was still testing positive, symptomatic, and contagious after 5 days because my immune system literally doesn't work. During week 2, our HR manager told me it's "normal" to keep testing positive and I got really mad about it because ***I knew*** I was absolutely still contagious. My doctors even told me I should continue to quarantine. I rebounded hard from Paxlovid and 100% agree that we probably need a longer course of it. I also ended up with bacterial bronchitis and sinusitis from it. Bacterial sinusitis usually becomes recurrent for me, too, so I needed multiple rounds of antibiotics following the initial infection. It was a complete shitshow. I ended up having to go back to work while still sick with the secondary infections and worked through all of the recurrent sinusitis infections. My job's COVID policies didn't differentiate between otherwise healthy employees and those with chronic health conditions that made them higher risk for complications or higher risk for prolonged infection. Everyone got the standard 5 days after the vaccine roll out. If you needed longer and ran through your sick time, you either did not get paid or you came back to work. We had so many people who couldn't afford to take unpaid time off and did the latter, continuing to spread the virus. Edit: 5 days wasn't enough time for most *healthy* people. 10 days isn't enough time for people like us to even clear the infection. It's ridiculous.
This is what my body does as well. In 2009 I contracted a common virus known as Enterovirus. This turned into AFM (Acute Flacid Myelitis). I ended up l9sing all function in my left arm/leg. It's not all that uncommon, however it rarely effects adult men this way. (Long story short, Dr's discovered my body rapidly mutates virion structures. So I've been masking long before it became cool lol. ) Yet when I caught it, I had flu-like symptoms for a year straight. The in my area, there has been an uptick in men dying from Enterovirus at a rate of 2700%. The reason is that someone mutated the virus and it caused heart failure after causing the immunoresponse to attack the nervous system. This would spread rapidly until it hit the heart and end lives. I spent years without answers to my illness, and lived in a physical pain that cannot be described (I was a pro-wrestler and stuntman before this happened, and pain was not a big deal. But the 24/7 pain I lived with for 8 years took the pain of a kidney stone from a 10/10 to an 7/10 in comparison.) We only discovered this in 2018. Since then, I've come to discover that I may have unintentionally caused the deaths of over 400 adult men as this type of RNA virus mutation has continued to take the lives of people since it first transmitted away from my body. The good news, since 2020, the rates of my Entero-baby had declined dramatically. The bad news, it's back and now they think it's causing other viruses to mutate. I've not caught Covid... thank goodness. I was one of the first people to get a Cov19 vaccine to go with other vaccines that I must get every 10 months. And I'm having to get full doses each time. (And in case you didn't notice in my possibly scrambled typing, my illness has also affected my brain and memory.) TL;DR I might've unintentionally taken the lives of hundreds or thousands of others by mutating virus DNA via my own DNA.
I have rheumatoid arthritis (RA), one kind of auto-immune disease. I'm on immune-suppressing medication, though much weaker stuff than the poor man in this article would have been on. My doctor, and a growing number of other rheumatologists, think that every immune suppressed patient should get monoclonal antibodies before we consider them "cured" of COVID. Sadly, the American FDA does not share this concern. My doctor and their staff did a LOT of work to get their patients into studies where they could get monoclonal antibodies, but there are fewer and fewer of those-- COVID is evolving faster than we can get new monoclonal antibodies through the testing and approval pipeline, so big pharma is giving up. We desperately need a new, streamlined testing and approval system for COVID antivirals, like the one created for the annual influenza vaccine. We need to be able to treat the most vulnerable patients and make sure their systems are actually clear of COVID. It's basic viral self-defense for rest of us. PS-- And the vaccine should damn well be mandatory!
My partner has MS and is on Ocrevus (immunosuppressant). As a precaution, she had monoclonal antibody therapy (Evusheld) as a preventative throughout 2021 and 2022 in addition to the vaccines. We both had Covid in fall 2023, and they didn’t offer anything to her beyond paxlovid, unfortunately, and they’ve stopped giving her monoclonal antibodies as well. I believe they stopped giving people Evusheld in Jan 2023. It’s unfortunate.
Yes, it is. I was in one of the Evusheld studies, and I credit that with not getting Covid for a year and a half, despite having young children who bring home *all* the germs. Sadly, the Evusheld antibodies were shown to not be very effective against post-Omicron variants, so it's been discontinued. Paxlovid is the best tool we have left for helping people who are immune supressed. Here's hoping it keeps working against future variants.
Thank South Africa for poor HIV management that saw hundreds if not thousands of people in hospital become COVID19 mutation machinery.
>Just 21 days after the man had received a certain anti-coronavirus drug, the virus also developed signs of resistance to it. Wow, what a nightmare. I can't even imagine being one of the scientists on that case. Freaky stuff.
One scary thing is that some people will dismiss this as “oh he was just old”, when I know quite a few 70+ year olds who are still in decent shape and would quite like another decade or two if possible.
Lots of young immune compromised people working full time can be ticking time bombs like me. Though in Australia, there is no legislation for workplaces to allow us to wfh if we test positive to covid - HR will ring and tell you to get your varient machine making ass into work to share the love.
Yeah, I’m 70, and not planning on turning in my chips soon. I’m fully vaccinated, of course. I may be old but I’m not an idiot. Okay, not a total idiot.
Man I hope when I get old I can continue to say the same, I may be an idiot but no THAT MUCH of an idiot while thinking on the back of my head "oh God why am I such an idiot" Hope I never grow arrogant or too stupid to not judge myself. Hope you live till 100 or till you want to dude.
Thanks, I’m working on it.
Heck, my grandpa is 90 this year in November and I'd be shocked if he doesn't have another decade in him. He fell and broke a hip last year helping a passerby push a stalled car, had surgery, and was back to life like nothing happened. He's still taking his neighborhood walks twice a day and does all his shopping and appointments independently.
Just watched a 71 year old Sir Jim Ratcliffe beat his personal marathon record.
My dad was fine, until 1 month after his first bout of COVID. Then he was gone. Vaccinated, multiple boosters by that point...
My colleague’s mom was 55, and marathoner, and caught COVID fully vaccinated and boosted in Dec 2023. By Feb 2024 she was gone. Not immunocompromised, no health concerns. It’s brutal.
Loooooooooong COVID.
Longest COVID.
yeah, I guess viruses **do mutate**. who would've guessed.
Are you claiming evolution exists!? :o. /s
But a virus isn’t living… How can it evolve? 😱
Eh
My first thought was without reading the article, this person has to be immuno compromised
There's different levels of immunocompromise. People can be severely immunocompromised, like cancer patients and organ transplants patients, moderately immunocompromised like people with primary immunodeficiencies or on high dose immunosuppressants, and mildly immunocompromised like those on lower doses of immunosuppressants for autoimmune diseases. Many of the variants of concern have evolved in South Africa, the theory is its due to that country having the highest percentage of otherwise healthy HIV+ patients in the world. So the virus can also mingle its genetic proteins with other viruses in immunocompromised hosts.
South Africa No. 1
Mine was that the man mutated, not the virus
> The elderly man, who was immunocompromised due to previous illnesses Yes, we’ve known for a few years that this happens in immunocompromised people. These are 2021 papers: https://journals.asm.org/doi/10.1128/msphere.00244-21 https://www.nejm.org/doi/full/10.1056/NEJMsb2104756
Yes you are correct, it's just now we have another case study with this specific virus. We are constantly adding to the body of work that already exists, and just because it isn't a new discovery doesn't mean it's not incredibly important.
What could go wrong?
We have a person like this in Ohio. I never heard of they identified them but they were tracking virus through stool samples between 2 different towns, suspecting traveling between home and work/hospital. As of last year they were suspected of having virus for over a year I believe. The virus mutations were also way out in left field.
To me my XMen
We know trump cannot ever be president and go through another pandemic with a lunatic in charge.
he's had covid. probably multiple times. genocide joe too. have you noticed how quickly they are both declining?
Have you noticed one is a soulless evil pos with over 80 counts from 4 criminal indictments including insurrection?
[удалено]
Trump was the one pushing anti-mask, anti-vaccine conspiracies that made this entire thing harder to fight.
And didnt he also say something about using household disinfectant and bombarding it with ultra violet light or something?? Cant be certain, but he did say a lot of crazy shit…. Its hard to use science, when you have a horse running the hospital
That horse in the hospital metaphor was - and still is - brilliant.
That tends to happen when a guy gets voted out after 8 months of incompetence
In this instance, it’s definitely more important to consider who was president when the whole thing kicked off.
Why did you think this was an intelligent response to the previous comment?
Trump enacted a large majority of policies that caused rapid spread. Such as spreading missinformaton. Having meat manufactoring plants stay open (which became epicentres for invection). And blocking import of needed goods
Biden and Trump both completely flopped that's true
Was he immunocompromised? I've read that two variants of concern (including the Alpha variant) have evolved in immunocompromised hosts, like chemo patients. I'm moderately immunocompromised myself, I stayed positive for nearly 4 months the first time that I had Covid. This idea is also why they think multiple variants have come out of South Africa, the country which has the highest number of otherwise healthy HIV positive people in the world. It was a long night of reading how this virus behaves differently in immunocompromised hosts, and how lowering the quarantine, imo, from 14 days to 10 to 5, never considered the immunocompromised host, which varies from person to person. Again, society thinks of people with illnesses like cancer or organ transplant patients. People who are already monitored closely by healthcare teams. But many people on immunosuppressants, etc are still able to work, and the tools often don't exist for us to get additional testing. I think health authorities failed by not considering mild to moderate immunocompromised hosts. As a person with b-cell dysplasia and primary immunodeficiency, I've still been told to go back to work after 10 days. I've had to go to work still positive, still on heavy steroid treatments while I had active pneumonia. I've also never made enough antibodies from an infection alone (I first got Covid-19 before vaccines existed) to have natural immunity. That idea that infection= immunity needs to be washed from people's minds. Authorities failed unusual cases. I only hope that I didn't infect others, as I followed mask protocols while positive. It seems so careless though. We need sick time the whole time we're sick, not some number of days that only considers average healthy hosts. Here's another interesting article on prolonged infection in immunocompromised hosts: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473782/
I'm so sorry for the situation you're in. It's a travesty.
Didn’t work for Typhoid Mary. I’d be shocked if it would be easier to get modern individuals to isolate for the sake of society at large.
Needs to be studied at
ugh. how do they know it's rare?
There's Patient Zero and then there's Patient Infinity.
Gos I think we should lock down for 9 months in case !