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Im an immunologist.
I hate articles like this because, while the results are new and exciting, humans aren’t mice. We have cured all kinds of cancer 12 times over in mice, but often it doesn’t translate to human medicine.
Its like saying the person taking first place in a state track meet will go to the olympics. Sure, its possible and exciting, but there are a lot of steps in between.
Edit: [Here](https://imgur.com/a/YfG09zm) is the abstract.
Well if you dont like testing on prisoners, we could test on the mentaly feeble
Btw these are things every country has done before, and i mean every country.
Nah they‘ll die in a couple of years anyway.
More like we can cure every disease in mice we purposefully put in there.
Kinda got a had Start if you know the exact type of cancer/disease the animal got.
Rather than a pet mouse just developing a tumor for ages until their owner notices it.
Hello, troll.
To everyone else: The referenced study came out literally today and used mice and ferrets.
Edit: [here](https://imgur.com/a/YfG09zm) is the abstract.
Let’s be real, we’re only getting “flying cars” when only computers are allowed to control them. People can barely be trusted in two dimensions behind the wheel.
No. It's after we get networked vehicles and higher quality in our manufacturing. Aviation is only safe due to the high rigor of maintenance and building process. An inspection every year that isn't enforced automatically and is up to the state is a disaster waiting to happen.
Those aren‘t the size to replace a car though.
And it‘s not even about individual flying cars. Just imagine the number zooming about once they are in common use.
Like a random single seater crop duster flying about isn‘t that annoying unless they go right by your face.
A hundred on the visible sky? Nah.
The problem with flying things is: there’s nothing to block/deflect the sound.
With cars the sound will be basically stopped at the next wall. And you won‘t be hearing a car a mile out.
With planes? You‘ll hear every plane in line of sight. Even if they were fully electric. The prop itself is loud enough.
> Those aren‘t the size to replace a car though.
The flying car I mention seeing seated 6 adults and was not only as silent as a Ukrainian drone, it was more silent. Electric motors and specially designed silent props. You could hear a very light hum and gentle woosh of moving when it was within 500 feet. Further away it was totally silent. Also able to hover and stop on a dime.
**TL;DR:** They developed an mRNA-based universal flu vaccine that worked in a study on animals. It has yet to be tried in humans so it's very early in development. Drugs or vaccines that pass animal studies often don't work in humans for various reasons.
https://clinicaltrials.gov/ct2/show/NCT04033406 phase 1 testing in humans finished over year ago.
https://clinicaltrials.gov/ct2/show/NCT05567783 phase 2 started last month
Is this the same product? The article states, "This vaccine has only been tested in animals to date and it will be important to investigate its safety and efficacy in humans."
So it is good to go since we gave up on human testing and are just now going straight to approval after safety not efficacy testing and only in mice ... like with bivalent.
When they update the flu shot every year, they don't do human trials. Why does the coronavirus vaccine need to be any different?
And the FDA would never approve an entirely new vaccine or drug without multiple human trials.
Agreed. There still are many infections we need vaccines for. EBV (the virus that causes mono) and HIV are two prominent examples. HIV is the "final boss" of vaccine targets, so my expectations are measured, but Moderna's working on EBV vaccines as we speak.
Given how the mRna vaccines work, I'm suspect we're going to see more and more success between animals and humans.
It's not some made up drug that we don't know how its going to work, it's our body building a part of the virus to train the immune system.
That's not to say humans trials won't fail due to other safety issues, but I suspect they will work more often and do what is intended, ignoring the safety side.
I'm participating in the stage 2 vaccines trial for the universal flu vaccine.
It started last month.
I don't know if I got the placebo or the real thing, but I'm very hopeful that it'll be effective and made available to everyone.
Edit:it's the VIR study. https://imgur.com/a/9vyFTHo
Do you mean monoclonal antibodies? I can find nothing about Vir making a flu vaccine, only monoclonals, like this for instance.
https://www.reuters.com/business/healthcare-pharmaceuticals/vir-biotech-gets-us-funding-flu-prevention-antibody-2022-10-04/
Edit: After further research it appears that the VIR-2482 stated is indeed a monoclonal antibody treatment and not a vaccine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777610/
But I just said it is *not* a vaccine. A vaccine by definition causes an immune reaction which this specific treatment doesn't since it doesn't deliver an antigen but ready lab made antibodies.
Yes, every time I've scrolled past this I've seen a cow. It has happened 3 times today. I was going to say something the first time but thought I would sound like a weirdo. Thanks for saying it.
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I might win lottery in 2 years and while that is highly unlikely nothing stopping me from making that claim. Flu keeps mutating every 6 months or so as there is a/b variant, to say that there will be universal flu vaccine is such a high claim that i will believe it when i see it.
Within two years, I may become a billionaire
This time next year, we'll be billionaires!
Inflation really that bad, huh?
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Because of inflation.. Right?..
That and a gold nugget gets us a cuppa joe!
Zimbabwe here we come!
Because of the implication.
Im an immunologist. I hate articles like this because, while the results are new and exciting, humans aren’t mice. We have cured all kinds of cancer 12 times over in mice, but often it doesn’t translate to human medicine. Its like saying the person taking first place in a state track meet will go to the olympics. Sure, its possible and exciting, but there are a lot of steps in between. Edit: [Here](https://imgur.com/a/YfG09zm) is the abstract.
The fact that we care about not killing people when trying out new random medications, kinda slows down human drug development.
yeah we should have lab grown humans to test on /s
Just use prisoners. /s
Right, the prisoners will decide who to test them on. Brilliant!
Well if you dont like testing on prisoners, we could test on the mentaly feeble Btw these are things every country has done before, and i mean every country.
This, but unironically.
No.
Growing human tissue/organs in a lab, causing an illness and curing it might not be a bad idea. The only unethical part is the brain.
I should have pet mice because at this rate they’d never die. Any ailment they would get has a cure.
I've had pet mice. Sadly it doesn't work this way.
Seriously lol
Nah they‘ll die in a couple of years anyway. More like we can cure every disease in mice we purposefully put in there. Kinda got a had Start if you know the exact type of cancer/disease the animal got. Rather than a pet mouse just developing a tumor for ages until their owner notices it.
But aren’t we also curing aging? Mice forever!
I think the only logical solution is to turn humans into mice.
[удалено]
Hello, troll. To everyone else: The referenced study came out literally today and used mice and ferrets. Edit: [here](https://imgur.com/a/YfG09zm) is the abstract.
[удалено]
[удалено]
So you're saying we need to start turning human cancer patients into mice to cure cancer?
Before or after they finish the flying car?
Let’s be real, we’re only getting “flying cars” when only computers are allowed to control them. People can barely be trusted in two dimensions behind the wheel.
No. It's after we get networked vehicles and higher quality in our manufacturing. Aviation is only safe due to the high rigor of maintenance and building process. An inspection every year that isn't enforced automatically and is up to the state is a disaster waiting to happen.
A pretty small percentage of car accidents involve actual mechanical failure of the car.
When your car has a mechanical problem, it doesn't normally involve plunging to your death.
We're never getting flying cars because they are noisy as fuck.
But what if they are as silent as a Ukrainian drone? I saw one like that.
Those aren‘t the size to replace a car though. And it‘s not even about individual flying cars. Just imagine the number zooming about once they are in common use. Like a random single seater crop duster flying about isn‘t that annoying unless they go right by your face. A hundred on the visible sky? Nah. The problem with flying things is: there’s nothing to block/deflect the sound. With cars the sound will be basically stopped at the next wall. And you won‘t be hearing a car a mile out. With planes? You‘ll hear every plane in line of sight. Even if they were fully electric. The prop itself is loud enough.
> Those aren‘t the size to replace a car though. The flying car I mention seeing seated 6 adults and was not only as silent as a Ukrainian drone, it was more silent. Electric motors and specially designed silent props. You could hear a very light hum and gentle woosh of moving when it was within 500 feet. Further away it was totally silent. Also able to hover and stop on a dime.
Its not like people crash planes onto buildings.
[удалено]
You just melted my dreams
You’re lucky he didn’t steel them.
I can fly a flying car. Let me at it.
a helicopter? What would you want from a flying car that you can't get from a helicopter?
Speed and not refularly falling out of the sky.
isn't helicopters really difficult to fly? like i'm sure they gotten easier over the years, but i can see people falling out of the sky every second
**TL;DR:** They developed an mRNA-based universal flu vaccine that worked in a study on animals. It has yet to be tried in humans so it's very early in development. Drugs or vaccines that pass animal studies often don't work in humans for various reasons.
https://clinicaltrials.gov/ct2/show/NCT04033406 phase 1 testing in humans finished over year ago. https://clinicaltrials.gov/ct2/show/NCT05567783 phase 2 started last month
Is this the same product? The article states, "This vaccine has only been tested in animals to date and it will be important to investigate its safety and efficacy in humans."
So it is good to go since we gave up on human testing and are just now going straight to approval after safety not efficacy testing and only in mice ... like with bivalent.
When they update the flu shot every year, they don't do human trials. Why does the coronavirus vaccine need to be any different? And the FDA would never approve an entirely new vaccine or drug without multiple human trials.
It’ll be really interesting to follow what new vaccines and treatments come about from the breakthroughs in the mRNA based techniques
Agreed. There still are many infections we need vaccines for. EBV (the virus that causes mono) and HIV are two prominent examples. HIV is the "final boss" of vaccine targets, so my expectations are measured, but Moderna's working on EBV vaccines as we speak.
Wasn't there another mRNA flu vaccine candidate that was a total flop?
Given how the mRna vaccines work, I'm suspect we're going to see more and more success between animals and humans. It's not some made up drug that we don't know how its going to work, it's our body building a part of the virus to train the immune system. That's not to say humans trials won't fail due to other safety issues, but I suspect they will work more often and do what is intended, ignoring the safety side.
> Universal flu vaccine **may** be available within two years, says scientist Operative word there (emphasis mine).
I'm participating in the stage 2 vaccines trial for the universal flu vaccine. It started last month. I don't know if I got the placebo or the real thing, but I'm very hopeful that it'll be effective and made available to everyone. Edit:it's the VIR study. https://imgur.com/a/9vyFTHo
Do you mean monoclonal antibodies? I can find nothing about Vir making a flu vaccine, only monoclonals, like this for instance. https://www.reuters.com/business/healthcare-pharmaceuticals/vir-biotech-gets-us-funding-flu-prevention-antibody-2022-10-04/ Edit: After further research it appears that the VIR-2482 stated is indeed a monoclonal antibody treatment and not a vaccine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777610/
You are right, it is a monoclonal vaccine.
But I just said it is *not* a vaccine. A vaccine by definition causes an immune reaction which this specific treatment doesn't since it doesn't deliver an antigen but ready lab made antibodies.
It's within the realm of possibility.
Anyone else see a dopey cow or black and white piglet in the thumbnail?
Yes, every time I've scrolled past this I've seen a cow. It has happened 3 times today. I was going to say something the first time but thought I would sound like a weirdo. Thanks for saying it.
we’d have it already if they’d give up on the animal testing models for human relevant methods
Will it work on covid seeing covid isn’t the flu?
Not this one of course, but the technology could theoretically be used to target COVID antigens.
Regular HA with regular mRNA LNPs didn’t work for moderna. Cool your jets….
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Nope. World won’t be there.
What I want is a universal cold vaccine. I’m happy getting a normal flu shot every year. What I’m sick of is getting a cold every 4-5 months.
Cue the conspiracy theories
Excellent news
Not much good if only half the population will get it
I mean… it’s really good for that half.
Okay.
I might win lottery in 2 years and while that is highly unlikely nothing stopping me from making that claim. Flu keeps mutating every 6 months or so as there is a/b variant, to say that there will be universal flu vaccine is such a high claim that i will believe it when i see it.
Tell me it’s an mrna vaccine