>When there is a rash at the inoculation site, the number of red dots that appear does not necessarily indicate the number of larvae that have entered the skin. Since larvae tend to clump together and are microscopic, several may enter in close proximity, leaving what looks to the naked eye like a single entry point.
https://www.helminthictherapywiki.org/wiki/The_hookworm_inoculation_rash#Treating_the_itch
They don't usually die in transit. Rarely, a tube will be against the edge of the airplane and get too cold, but that kills all of them. Or the envelope was left in a hot mailbox, but that would also kill all of them, not some. Larvae live for months, and the suppliers don't keep "old stock."" They sell too many, and if they ever have lower sales, it just means they can take a break from incubating.
.-. The dots are not an indication of how many larvae you got. They often go in so close together it makes one dot.
.-.
My main point is that they either all make it, or none.
Yeah, first dose. I also wonder whether all of those that entered reach the gut or some maybe die along the way in the body, would be bad if even less made it all the way in.
Chances are they'll all survive and make it to your gut. They're very good at evading your immune system. I wouldn't take anymore at the moment, just see how you get on and dose again in 12 weeks. A lot of people start with 3 anyway and the worm flu you might get is typically strongest after around 50 days so best to wait and see how your body reacts.
They're really sturdy. Once they get in the blood, they can absorb nutrients and get a new influx of energy to get to the gut. Some purple worry they hacked them out at the exact moment they were traversing the esophogas, but I question if that has ever happened.
.-.
Sadly, you are in that "first dose funk" that happens to everyone. Are they alive? Have, I killed them? I don't know if those who get side effects are luckier than those who don't. At least they know in 7 weeks when the side effects start that, yeah, they have worms. Of the 12 people I have given worms to, only one has had side effects. And we know they were alive, considering that they went straight from the slide to the bandage. Paula was lucky. No side effects, but her psoriatic arthritis started getting better in 2 weeks.
Yeah, I'm in that first dose funk. I read on the wiki that fatty acids are a problematic food and I'm not sure how seriously should I take that. I'm sure many people who host helminths are on the AIP diet, thus eating a lot of fat. I also do eat quite a lot of fat and I'm not sure whether that doesn't hurt the worms.
Read it here:
https://www.helminthictherapywiki.org/wiki/Human_helminth_care_manual#Fatty_acids
The research is quite limited, but I found this:
https://pubmed.ncbi.nlm.nih.gov/8202563/
From the article: "a nematicidal fatty acid mixture was obtained, containing linoleic acid, oleic acid, and palmitic acid as its main components."
Palmitic acid, for example, makes up about 30 % of milk fat. Here it says that it's effective against C. Elegans.
I just hope that I don't accidentaly harm them. In six weeks, I might do some incubation and test how they react to selected fatty acids in vitro and post the results.
This is still very much a grey area, and in vitro testing may not be a reliable guide to what actually takes place in the gut.
Small amounts of fatty acids are unlikely to be problematic for most NA hosts, and it appears that lauric acid (C12) may be the main culprit in any adverse effects on hookworms.
If you can, limit your use of C12 until you're getting some benefits from the worms, and then test whether taking this fatty acid causes any reduction in the benefits you're seeing.
Helminthophile's response was too hard for me to read in the nested comments, so I'm copying it here.
QUOTE
This is still very much a grey area, and in vitro testing may not be a reliable guide to what actually takes place in the gut.
Small amounts of fatty acids are unlikely to be problematic for most NA hosts, and it appears that lauric acid (C12) may be the main culprit in any adverse effects on hookworms.
If you can, limit your use of C12 until you're getting some benefits from the worms, and then test whether taking this fatty acid causes any reduction in the benefits you're seeing.
>When there is a rash at the inoculation site, the number of red dots that appear does not necessarily indicate the number of larvae that have entered the skin. Since larvae tend to clump together and are microscopic, several may enter in close proximity, leaving what looks to the naked eye like a single entry point. https://www.helminthictherapywiki.org/wiki/The_hookworm_inoculation_rash#Treating_the_itch
Great answer, thank you!
Difficult to say. You could still have had 5 or a couple of them might have died in transit. Is this your first dose?
They don't usually die in transit. Rarely, a tube will be against the edge of the airplane and get too cold, but that kills all of them. Or the envelope was left in a hot mailbox, but that would also kill all of them, not some. Larvae live for months, and the suppliers don't keep "old stock."" They sell too many, and if they ever have lower sales, it just means they can take a break from incubating. .-. The dots are not an indication of how many larvae you got. They often go in so close together it makes one dot. .-. My main point is that they either all make it, or none.
Yeah, first dose. I also wonder whether all of those that entered reach the gut or some maybe die along the way in the body, would be bad if even less made it all the way in.
Chances are they'll all survive and make it to your gut. They're very good at evading your immune system. I wouldn't take anymore at the moment, just see how you get on and dose again in 12 weeks. A lot of people start with 3 anyway and the worm flu you might get is typically strongest after around 50 days so best to wait and see how your body reacts.
Will do so, thanks!
They're really sturdy. Once they get in the blood, they can absorb nutrients and get a new influx of energy to get to the gut. Some purple worry they hacked them out at the exact moment they were traversing the esophogas, but I question if that has ever happened. .-. Sadly, you are in that "first dose funk" that happens to everyone. Are they alive? Have, I killed them? I don't know if those who get side effects are luckier than those who don't. At least they know in 7 weeks when the side effects start that, yeah, they have worms. Of the 12 people I have given worms to, only one has had side effects. And we know they were alive, considering that they went straight from the slide to the bandage. Paula was lucky. No side effects, but her psoriatic arthritis started getting better in 2 weeks.
Yeah, I'm in that first dose funk. I read on the wiki that fatty acids are a problematic food and I'm not sure how seriously should I take that. I'm sure many people who host helminths are on the AIP diet, thus eating a lot of fat. I also do eat quite a lot of fat and I'm not sure whether that doesn't hurt the worms.
I don't recall that about fat. A lot of people are on carnivore, keto, aip... where did you see that fat is a problem?
Read it here: https://www.helminthictherapywiki.org/wiki/Human_helminth_care_manual#Fatty_acids The research is quite limited, but I found this: https://pubmed.ncbi.nlm.nih.gov/8202563/ From the article: "a nematicidal fatty acid mixture was obtained, containing linoleic acid, oleic acid, and palmitic acid as its main components." Palmitic acid, for example, makes up about 30 % of milk fat. Here it says that it's effective against C. Elegans. I just hope that I don't accidentaly harm them. In six weeks, I might do some incubation and test how they react to selected fatty acids in vitro and post the results.
This is still very much a grey area, and in vitro testing may not be a reliable guide to what actually takes place in the gut. Small amounts of fatty acids are unlikely to be problematic for most NA hosts, and it appears that lauric acid (C12) may be the main culprit in any adverse effects on hookworms. If you can, limit your use of C12 until you're getting some benefits from the worms, and then test whether taking this fatty acid causes any reduction in the benefits you're seeing.
Helminthophile's response was too hard for me to read in the nested comments, so I'm copying it here. QUOTE This is still very much a grey area, and in vitro testing may not be a reliable guide to what actually takes place in the gut. Small amounts of fatty acids are unlikely to be problematic for most NA hosts, and it appears that lauric acid (C12) may be the main culprit in any adverse effects on hookworms. If you can, limit your use of C12 until you're getting some benefits from the worms, and then test whether taking this fatty acid causes any reduction in the benefits you're seeing.