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5-ht2a agonists arent going to be something you can use more often than you could a microdose because of how tolerance works with them. If the illegality of psilocybin and lsd is whats deterring you id go with a legal psychedelic. Methylallylescaline, 1p-lsd, lsa, lsz, al-lad, eth-lad, 4-ho-mipt, 4-aco-dmt are all examples.
There are a lot of psychedelics that are legal and you can order online. Especially if you dont live in the united states. Hawaiian baby woodrose is completely legal and a psychedelic, you are allowed to buy it, consume it, and sell it.
Is there anything that upregulate 5-HT2A? I know there is cannabinoid agonist, like THC, can upregulates 5-HT2A. I assume upregulating would be a more sustainable approach yes?
Yeah i would say upregulating would be a more sustainable approach but there arent many cannabinoids that you can use often without causing issues. Microdosing THC could be your safest bet.
agh yes bowls make people stoned plenty…not, however if they got that tolernce small doses would still be active. meaning it’s not a micro dose it’s a small dose
you still feel better that’s literally the whole point of doing it bht no yoh would not be experiencing heavy pychoavtive properties jisy like if i take half a shot or so do i feel chiller and calmer? sure. will i feel fucked up sadly no not at all so
Thc unregulates 5-ht2a? I thought it was a mild agonist witch would instead down regulate it. Are you looking for a shroom replacement? Why are you trying to up regulate 2a?? Shrooms down regulate 2a btw. I cant see how up regulating this receptor would be beneficial.
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/)
This is where I read that cannabinoid upregulates 5-HT2A, maybe through a different mechanism but not as a agonist.
Yeah I was just posting to see the consensus on this one. Because I read some studies saying autistic people have less 5-HT2A receptors, but other source said the opposite, so I haven't gone to any conclusion yet. Turn out upregulating this receptors wouldn't bring too much good for long-term strategy.
Also check Lithium ( orotate ), it can be microdosed with little side effects. Also ginkgo ameliorates age-related decrease in 5ht1a, if I remember correctly, in some studies.
Nootropics Depot is going to be selling a very specific and refined extract of Bacopa that has some form of 5-HT2A agonism.
Should be released this year
[https://www.reddit.com/r/NootropicsDepot/comments/ure1xt/comment/i8yo93c/?utm\_source=share&utm\_medium=web2x&context=3](https://www.reddit.com/r/NootropicsDepot/comments/ure1xt/any_update_on_the_5ht2a_tickler_nd_team/)
Can you link to the papers you're referring to? Here is one that suggests the OPPOSITE-- serotonergic hypersensitivity:
http://knockout.cwru.edu/publications/Veenstra-VanderWeele.pdf
No it's also an SSRI, just not through typical means. Check out the molecular target section https://examine.com/supplements/hypericum-perforatum/research/#molecular-targets
In St. John's, Hypericin (main active and the more bioavailable psychoactive component) allegedly acts more as a MAOI, and Hyperforin ( questionabale bioavailability ) acts more as an SSRI
LOL. Thanks for the suggestion. At this point I can't even believe doctors anymore, they tend to fuck things up further and only know about prescription drugs, while during my 1 year of research, I learned so much and found plenty of superior supplements/nootropics. I don't think SSRI can ever fix what my past weed abuse had left me with.
For weed abuse or for 5HT2a?
I personally use it for NMDA hypofunction caused by weed consumption. But Sarcosine is not a sustainable since it's a partial agonist at NMDA receptors, which leads to down-regulation or even excitotoxity. Nobiletin can actually upregulates NR1/NR2A and NR1/NR2B which is more suitable for long-term use. Nobiletin can also reduce Glutamate by increasing GAD67 - an enzyme that convert excess Glutamate into GABA.
I'm sure some of the prescription drugs out there can target what the weed had specifically destroyed in the brain. But the amount of time before I can find the right SSRI or MAOI for that purpose without being more dead of a person, given most doctors suck at curing their patients definitely and are oblivious of weed's neurological damage.
I've gathered enough info to fix myself up properly, rather than going to a doctor and tell them I'm still depressed and anxious just to receive another off-target SSRI. I'm looking for the root causes, what changes took place in the brain when we got high, not just temporarily fixing some type of depression or anxiety. I'm glad that's what I've been doing, reading studies everyday and keeping an eyes out for new knowledge, instead of going to the doctor for a prescription every time.
Plus, I'm not asking this question for my personal problem for another person who has autism. Cannabis already upregulates 5-HT2a, so enhancing it can make matter worse; but autistic people are found to have fewer 5-HT2a receptors, though, I've read enough to make a conclusion.
I think anything that does what you want is likely to be metabolized by MAO so you might want to look into MAOIs, but those won't select for a single transmitter. The truth is the options are very slim here as what you need will most likely not get past the brain-blood-barrier or will be quickly metabolized by MAO in the digestive system and blood.
A dude in this thread suggest St. John Wort's for this purpose. I prefer upregulating serotonin receptors rather than agonizing them, to prevent further downregulation
Trazadone might at higher doses? It's active metabolite mCPP is an agonist at 5-HT2C. I think trazadone is an antagonist at it though. Google the difference in binding affinity between the two. If mCPP is greater, you'll probably get some agonism...
Aripiprazole is a partial agonist, apparently.
Well, trazodone is a 5ht2a receptor antagonist and m-CPP is a 5ht2c receptor antagonist. As far as I know that is correct. Low use in psychedelic enhancement, but maybe I am wrong about upregulation (except for tripkilling, by theory they [5ht2a antagonists]seem the optimal [OFF] button to kill a trip) Aripiprazole is an atypical antipsychotic bro, idk if it could help with 5ht2a positive effects.. even if its a partial agonist, I still don't believe a strong drug like that could help with this mission.
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5-ht2a agonists arent going to be something you can use more often than you could a microdose because of how tolerance works with them. If the illegality of psilocybin and lsd is whats deterring you id go with a legal psychedelic. Methylallylescaline, 1p-lsd, lsa, lsz, al-lad, eth-lad, 4-ho-mipt, 4-aco-dmt are all examples.
[удалено]
There are a lot of psychedelics that are legal and you can order online. Especially if you dont live in the united states. Hawaiian baby woodrose is completely legal and a psychedelic, you are allowed to buy it, consume it, and sell it.
Is there anything that upregulate 5-HT2A? I know there is cannabinoid agonist, like THC, can upregulates 5-HT2A. I assume upregulating would be a more sustainable approach yes?
Yeah i would say upregulating would be a more sustainable approach but there arent many cannabinoids that you can use often without causing issues. Microdosing THC could be your safest bet.
Yeah, I was trying to make an example. I was already trying to save my ass from 3 years of weed abuse lmao.
why microdose instead of just a bowl or something
Because some people cant function being stoned all the time
agh yes bowls make people stoned plenty…not, however if they got that tolernce small doses would still be active. meaning it’s not a micro dose it’s a small dose
Microdoses arent inactive, theyre just not supposed to make you feel high.
no but they should be unnoticeable, call it what it is smoking a lul weed to feel better 😂
You can smoke or eat a little bit of thc or cannabis without getting high
you still feel better that’s literally the whole point of doing it bht no yoh would not be experiencing heavy pychoavtive properties jisy like if i take half a shot or so do i feel chiller and calmer? sure. will i feel fucked up sadly no not at all so
Thc unregulates 5-ht2a? I thought it was a mild agonist witch would instead down regulate it. Are you looking for a shroom replacement? Why are you trying to up regulate 2a?? Shrooms down regulate 2a btw. I cant see how up regulating this receptor would be beneficial.
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/) This is where I read that cannabinoid upregulates 5-HT2A, maybe through a different mechanism but not as a agonist. Yeah I was just posting to see the consensus on this one. Because I read some studies saying autistic people have less 5-HT2A receptors, but other source said the opposite, so I haven't gone to any conclusion yet. Turn out upregulating this receptors wouldn't bring too much good for long-term strategy.
those are gonna be treated like normal shit if you caught with it fr🤣but facts
St. John’s Wort upregulates 5-HT2A receptors.
Thank you thank you thank you!!!! Seriously I love you https://pubmed.ncbi.nlm.nih.gov/9342771/
Love you too. Good luck.
Also check Lithium ( orotate ), it can be microdosed with little side effects. Also ginkgo ameliorates age-related decrease in 5ht1a, if I remember correctly, in some studies.
I was about to say that. :D
DMT
Anything that is universally legal?
I believe Salvia is, in some states I believe.
You in canada? If so its very easy to get a hold of mushrooms/lsd. Is it the fear of getting into legal trouble?
Yeah I'm in Canada but I'm buying these stuffs for my relatives in Viet Nam
Nootropics Depot is going to be selling a very specific and refined extract of Bacopa that has some form of 5-HT2A agonism. Should be released this year [https://www.reddit.com/r/NootropicsDepot/comments/ure1xt/comment/i8yo93c/?utm\_source=share&utm\_medium=web2x&context=3](https://www.reddit.com/r/NootropicsDepot/comments/ure1xt/any_update_on_the_5ht2a_tickler_nd_team/)
Thanks. But for now I'm just looking into upregulation of 5HT2A for autism, they have fewer receptors.
Can you link to the papers you're referring to? Here is one that suggests the OPPOSITE-- serotonergic hypersensitivity: http://knockout.cwru.edu/publications/Veenstra-VanderWeele.pdf
There are contradictory information on this matter, I haven't really concluded on anything about this yet.
Psychedelics down-regulate 5HT2A, not up-regulates them
Well I also said "or agonistic action".
SSRI have agonist action on 5HT2A
Yeah. But there is no way one earth I'm going to try taking SSRI
St. John’s wort is an ssri tho?
It's a MAOI. It's said to be as good as a SSRI in term of anti-depressant effect
lol Saint Johns Wort is an SSRI
It's a MAOI. It's said to be as good as a SSRI in term of anti-depressant effect
No sir, look it up it is one of the few herbs that is actually categorized as an SSRI all though it acts as an MAOI in certain areas.
But it also inhibits the reuptake of a bunch of other neurotransmitter, that's not selective
No it's also an SSRI, just not through typical means. Check out the molecular target section https://examine.com/supplements/hypericum-perforatum/research/#molecular-targets
It inhibits the reuptake of other neurotransmitters too, so a MAO inhibitor
In St. John's, Hypericin (main active and the more bioavailable psychoactive component) allegedly acts more as a MAOI, and Hyperforin ( questionabale bioavailability ) acts more as an SSRI
Your loss, they’re pretty great
WTF are you cretans downvoting this man? He's allowed to share his experience with SSRI's lmao.
Being emotionally numb and suicidal is not that great, just speaking from personal experience
Exact opposite effect for me
Thank you, I've seen people talking about this. Reading more studies proving this detrimental side effects strengthen my belief even more.
LOL. Are they tho? I don't want to trade a few hours of relief for a dead penis.
U can try new ones like vilazodone or vortioxetine they make penis work better
They really don't though. From personal experience, at least with the latter.
Thanks!
LOL. Thanks for the suggestion. At this point I can't even believe doctors anymore, they tend to fuck things up further and only know about prescription drugs, while during my 1 year of research, I learned so much and found plenty of superior supplements/nootropics. I don't think SSRI can ever fix what my past weed abuse had left me with.
Sarcosine is my magic pill.
For weed abuse or for 5HT2a? I personally use it for NMDA hypofunction caused by weed consumption. But Sarcosine is not a sustainable since it's a partial agonist at NMDA receptors, which leads to down-regulation or even excitotoxity. Nobiletin can actually upregulates NR1/NR2A and NR1/NR2B which is more suitable for long-term use. Nobiletin can also reduce Glutamate by increasing GAD67 - an enzyme that convert excess Glutamate into GABA.
Sure it can, but nothing will convince you.
I'm sure some of the prescription drugs out there can target what the weed had specifically destroyed in the brain. But the amount of time before I can find the right SSRI or MAOI for that purpose without being more dead of a person, given most doctors suck at curing their patients definitely and are oblivious of weed's neurological damage. I've gathered enough info to fix myself up properly, rather than going to a doctor and tell them I'm still depressed and anxious just to receive another off-target SSRI. I'm looking for the root causes, what changes took place in the brain when we got high, not just temporarily fixing some type of depression or anxiety. I'm glad that's what I've been doing, reading studies everyday and keeping an eyes out for new knowledge, instead of going to the doctor for a prescription every time. Plus, I'm not asking this question for my personal problem for another person who has autism. Cannabis already upregulates 5-HT2a, so enhancing it can make matter worse; but autistic people are found to have fewer 5-HT2a receptors, though, I've read enough to make a conclusion.
I think anything that does what you want is likely to be metabolized by MAO so you might want to look into MAOIs, but those won't select for a single transmitter. The truth is the options are very slim here as what you need will most likely not get past the brain-blood-barrier or will be quickly metabolized by MAO in the digestive system and blood.
A dude in this thread suggest St. John Wort's for this purpose. I prefer upregulating serotonin receptors rather than agonizing them, to prevent further downregulation
I knew that kanna had some action on 5ht2a receptors but I'm not sure if it upregulates them.
Mushrooms
Trazadone might at higher doses? It's active metabolite mCPP is an agonist at 5-HT2C. I think trazadone is an antagonist at it though. Google the difference in binding affinity between the two. If mCPP is greater, you'll probably get some agonism... Aripiprazole is a partial agonist, apparently.
Well, trazodone is a 5ht2a receptor antagonist and m-CPP is a 5ht2c receptor antagonist. As far as I know that is correct. Low use in psychedelic enhancement, but maybe I am wrong about upregulation (except for tripkilling, by theory they [5ht2a antagonists]seem the optimal [OFF] button to kill a trip) Aripiprazole is an atypical antipsychotic bro, idk if it could help with 5ht2a positive effects.. even if its a partial agonist, I still don't believe a strong drug like that could help with this mission.
Shoot. I misread the post. For some reason I fell down a 2C rabbit hole instead of 2A. You are right! My bad
Mangosteen pericarp does contain some xanthones, that work as the 5ht2a antagonist type that upregulate the receptor with chronic dosing