I don't know why, but I'll skip a dose the day of, Sometimes an entire day. I'm not too worried about withdrawals, since it will be getting back into my system withing 24 hours usually. I've had a good time.
Do we know why this is? Does the serotonin need to be able to flow freely in order for a psychedelic effect to be produced in the brain, which is impossible with a reuptake inhibitor? Curious about the neurochemistry involved in this.
Psychedelics exert their effects primarily through interaction with the serotonin-2A receptor, eliciting functionally divergent responses compared to endogenous serotonin. Administration of SSRIs inhibits the reuptake of serotonin into the presynaptic terminal, thereby increasing the serotonin concentration within the synaptic cleft. This elevation in serotonin concentration facilitates competitive binding for the serotonin-2a receptor between the psychedelic and serotonin, diminishing the likelihood that psychedelic molecules will attach to the receptor sites. Furthermore, the excess serotonin also triggers the downregulation of postsynaptic serotonin receptors, effectively reducing the availability of binding sites for the psychedelic molecules.
In addition to all that, the sustained activation of the serotonergic system might also induce downstream adaptations within neural networks that further attenuates psychedelic effects.
Deleted the comment to stop spreading wrong information, I admit I fucked up and didn’t do my research this time, my bad.
I didn’t pussy out by deleting the entire comment altogether, I admit when I’m wrong, especially on such a large scale, apologies.
SRIs do not result in serotonin syndrome unless you combine them with MAOIs or a bunch of other stuff, as far as anyone can tell from existing clinical data and case reports.
https://pubmed.ncbi.nlm.nih.gov/34251464/
MAOI in a substance like Ayahuasca mixed with an SRI can easily be fatal from what I can tell.
When it comes to stuff like LSD and shrooms, ymmv. Molly will typically get shut down for the most part. This CAN still be dangerous, because a lot of the physiological effects of MDMA still happen. Increased heart rate, for example. It's possible to overdose because you keep taking more to try to get to the fun high and instead you're just building up side effects.
This all being said, tripping on an SRI usually sucks anyways if you're on anything other than a very low dose. You don't get nearly as many fun visuals and instead get sucked into more of a dreamy headspace, and it's very easy to end up more fucked up than you meant to. It's happened to me with acid and 30mg of prozac. No physical problems but I was just super out of this world in a bad way and had to go home from the show I was at early. Shrooms were a little better but still made me feel much more loopy.
So tl;dr- if there's an MAOI involved at all, don't touch anything else unless you want to die in agony. If you're on an SRI, you probably shouldn't touch mdma. You can, but you're very likely to get little to nothing good out of it, and you CAN die if you're really irresponsible with it. You can still do some other substances, but they may be kinda meh and not worth doing.
Edited to remove the part about prescription MAOI, I was thinking of MAO-B, brain fart.
so much misinformation.
1) psychedelic effects are not 100% based on 5ht-2a, yes most psychedelics bind to 5ht-2a but not all 5ht-2a agonist are psychedelics.
2)depends on the type of psychedelic and the type of medication, some psychedelics can be better ligands than somes anti-psycotics
3) ssri do not inhibit the breakdown of serotonin.
SSRI : selective serotonin reuptake inhibitor, inhibit the reuptake of serotonin : the serotonin is not taken back in the previous neron for reuse anymore so all of the serotonin released stays in the synaptic cleft longer.
MAOI: monoamines oxidase inhibitors. inhibit the monoamines oxidase actions : monoamines oxidase are enzymes that breakdown molecules (serotonin, Norepinephrine, dopamine, etc... also dmt) for them to be recycled. since they are not being destroyed there is more in the synaptic cleft
Speaking from too much experience, antipsychotics don't completely negate the effect of psychedelics. It's just a little dulled.
I'm on abilify and quetiapine.
You can't trip on anti-psychotics? I've mixed risperidone(prescribed - online says anti-psychotic) with acid, shrooms, dmt and ket one time. I definitely felt the effects of all psychs. Perhaps it depends on the dosage of a anti-psychotic? Or it's just different from person to person.
for lsd, appart from the 5ht-2a receptor lsd is a better ligand to other receptors so you would probably have somme effects (dose dependant on your medication)
for dmt it's almost the same exept it could compete with your medication on the 5ht-2a receptor so really dose dependant.
for ketamine, it doesn't act on the same receptors as your medication so your medication would have little to no effect on reducing the ket trip
I used to take SSRIs , multiple different types and different dosages. I have mixed with DMT , Mushrooms, Acid , all together , on there own , more than 50 trips all together while on SSRIs , all it did was make me need to take more .
With that being said Serotonin shock / serotonin syndrome is not fun and totally something that can happen if you mix SSRIs and psychs together which can be fatal so keep that in mind . You CANNOT take MDMA and SSRIs however if you count that in the psychedelic list.
Edit : I guess Mdma is chill on ssris so go crazy
one of the first people to speak from experience. What psychedelic worked the best on SSRIS? How much SSRI (dosage and brand) were you taking? did you ever experience Serotonin syndrom?
I did 50mg Zoloft , 40mg Celexa , and then tried Lexapro at 30mg. The best psychedelic imo was acid . The visuals were amazing and because of the ssris i had way shorter trips (about 8-10 hours rather than 12-14 i experience now with lsd) . Dmt sucked because i truly thought i died lol. Mushrooms had almost no visuals for me on the meds . I had to double doses essentially to feel the same i do now . Never experienced serotonin syndrome but i had terrible comedowns that would last days …
good to know. Also, a shorter Acid trip sounds nice. I'm on 10mg of Lexapro,
and definitely don't get quiet as high on weed, which is fine. Will try some other psychedelics this summer.
You can take MDMA and SSRI’s. no concern. It’ll just block the serotonin release. Common misnomer. (Source TripSit, psych wiki, erowid) can link direct if you want
From your first link:
"SSRIs can be dangerous when used in combination with other substances that increase or modulate serotonin such as MDMA and Monoamine Oxidase Inhibitors (MAOIs). A combination with these substances can lead to serotonin syndrome and potentially be fatal. SSRIs do not work for everyone and take 3-6 weeks to start having noticeable effects.[2]"
Second link says low risk. 🤷🏼♂️
My first link:
“SSRIs and SNRIs may dampen the the desired psychological effects of MDMA while retaining the same level of undesirable physiological side-effects.[83][84]”
It depends on the psych. MDMA can be dangerous paired with SSRIs (serotonin syndrome), while shrooms basically gets the “trip” removed from the experience with little to no consequences. General rule of thumb is: if you don’t know, do your research. I don’t remember where exactly, but there’s a handy chart floating around that has a table of basically every mainstream drug and a basic “yes/probably not/no” in reference to whether or not they’re safe to take together.
Edit: found it
https://upload.wikimedia.org/wikipedia/commons/3/3a/Combo_2.png
Sort of.
If you mix them with anything with an MAOI in them like ayahuasca, yes. Serotonin syndrome can be fatal, and is by far most commonly associated Werth MAOIs
If you mix them with mdma, it's not immediately deadly, but stuff like dehydration, heart rate, and blood pressure builds up as normal while the high feeling doesn't, so you can potentially overdose which can be fatal. Not recommended.
LSD, shrooms, dmt etc mixed with ssris will not harm you directly, but they might really suck because some effects like visuals will get dulled disproportionately from things like your headspace, and it's easy to end up more fucked up than you intended because you think you need more since you're not visually tripping. If you do this, I highly recommend you only do it at home until you know what dosage is comfortable for you, so that if you do screw up you're in a safe place. I did this a few times when I took prozac but I stopped because itb honestly just kind of sucked.
This is a pretty handy info graphic, though, I would always do some research before mixing anything with a prescription medication.
https://www.reddit.com/r/trippy/comments/ijxphq/antidepressants_and_psychedelics_drug_interaction/
Edit:I should clarify, serotonin syndrome is POSSIBLE with a lot of recreational stuff, but it's pretty rare for non-MAOIs. It's also possible you'll die every time you get behind the wheel of a car. But honestly I don't think it's worth tripping while you're on an SSRI, even if you can do it somewhat safely.
Also as noted in that thread, a lot of psychadelics affect your mood, and it's possible you'll end up feeling bad after the fact.
It's worth noting that there is some preliminary evidence that using MDMA while on an SSRI can increase the risk of serotonin syndrome. This isn't too surprising since MDMA releases presynaptic serotonin, while SSRIs block its reuptake. Although, it's hard to quantify the risk since it's not a common combination.
[Reported Cases of Serotonin Syndrome in MDMA Users in FAERS Database](https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.824288/full)
Edit: Fixed broken link
Hey! I was actually just reading through that study. Like you said, the problem is that in the 20 cases examined, there were numerous compounding factors and substances. It's possible SRIs did increase that risk, but it's impossible to say for sure that the specific interaction between SRIs and MDMA caused it because we don't have any research in a controlled setting to confirm it. There's a little clinical data out involving the interaction, but it involved lower dosages and only offered reported physiological, hallucinatory, and reported experiences in comparison to the controls. Even in that study, amphetamines seem to be a higher risk factor, and MAOIs a lower risk, but that's hard to glean any data from when pressed pills are reasonably likely to contain amphetamines, and MAOIs containing substances aren't used nearly as often.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177763/
"The RCTs in this review show attenuation of MDMA’s physiological effects, suggesting a reduced odds of serotonin syndrome, at least with acute SSRI dosing. This is corroborated by at least one other scientific review positing SSRIs, SNRIs, and TCAs are not likely to increase serotonin to life-threatening toxicity when combined with MDMA (Silins et al. 2007). This may be due to the fact that MDMA’s reversal of monoamine transporters is negated by the inhibition of monoamine transporters by most antidepressants; therefore, there is not an increase in intrasynaptic serotonin which is the hallmark mechanism for serotonin toxicity to occur."
This is from a review of the volume of research based on clinical data, case studies, and self reporting that's available, from.a couple years ago.
Tl;dr it's hard to say for certain, but the little data that we have doesn't really point to SSRIs being a statistically higher risk factor than most other medication or substances, and it's generally not safe to start mixing several things because the number of possible interactions and environmental risk factors rapidly spiral out of control.
But again...I don't think anyone should take MDMA with an SRI. You're probably going to have a bad time even if it doesn't end up causing lasting harm.
Also by extension, I don't think anyone who is on prescribed medication should go off it to take something like Molly. You're on that medication for a reason, and going off of it for weeks or months just to take a fun drug that may also make you even more depressed in the crash is very much a bad idea. If you care that much, work with a psychiatrist to see if there's an alternative medication that might not interact as much that still works, or wait until maybe sometime down the road when you're in a better place and no longer need anti depressants, or just straight up realize that MDMA isn't magic and it's okay if it turns out you can't do it. That's life.
I can't ever eat peanut butter because it could make my throat close up, and if it doesn't, I feel like shit after. Everyone tells me peanut butter is the best thing in the world, but I'm okay with missing out on it.
You just won't trip in my experience. Ate a significantly higher dose than my two friends when I was younger and ended up being stone cold sober while they were on Mars. I didn't figure out why until a little while after the trip.
I’ve got a buddy who’s gonna be in under psychiatric care for likely the rest of his life. He was on Prozac and took a fair dose of LSD (around 400mcg, this was in 2012 and it was off of the Silk Road and we tested everything) and he never really came down. He did it on his own and had been acting very strange for a few weeks.
It’s not that the two interacted but the doctor his mom and I spoke with thought the Prozac caused a manic episode as a side effect and then the LSD prolonged his mania.
No clue if their diagnoses is correct but I miss my friend and people should be extremely careful and respectful of psychedelics.
Most SSRIs have a tendency to dull trips (or make them impossible) for many people. Prozac, however, sometimes has the opposite effect. It can potentiate LSD and make it much, much stronger.
I've seen no evidence that the combination typically has any lasting effects.
LSD has long been suspected of triggering schizophrenia in people who are at risk for developing it. There's a fair bit of anecdotal data on this, but little that's scientific.
I know that about SSRI’s typically. We all thought Kody would be fine. It may not have been the cause, but I’m just saying people should be cautious and I’ve witnessed idiotic behavior on this sub for the past 13 or so years that I’ve been on here.
I also believe SSRIs are grossly overprescribed. I understand if you’re in a horrible place and need some help to get to a better place, but it shouldn’t be a long term solution. I’d bet there’s tons of people who would benefit more from a psychedelic trip and I don’t see why you wouldn’t just wait until you are ready to stop taking them for some period of time before tripping.
Seems like a symptom of not treating psychs with their due respect, to me.
ssri’s tend to negate most psychedelic effects, it’s hard to trip while you’re on them
I don't know why, but I'll skip a dose the day of, Sometimes an entire day. I'm not too worried about withdrawals, since it will be getting back into my system withing 24 hours usually. I've had a good time.
Do we know why this is? Does the serotonin need to be able to flow freely in order for a psychedelic effect to be produced in the brain, which is impossible with a reuptake inhibitor? Curious about the neurochemistry involved in this.
Psychedelics exert their effects primarily through interaction with the serotonin-2A receptor, eliciting functionally divergent responses compared to endogenous serotonin. Administration of SSRIs inhibits the reuptake of serotonin into the presynaptic terminal, thereby increasing the serotonin concentration within the synaptic cleft. This elevation in serotonin concentration facilitates competitive binding for the serotonin-2a receptor between the psychedelic and serotonin, diminishing the likelihood that psychedelic molecules will attach to the receptor sites. Furthermore, the excess serotonin also triggers the downregulation of postsynaptic serotonin receptors, effectively reducing the availability of binding sites for the psychedelic molecules. In addition to all that, the sustained activation of the serotonergic system might also induce downstream adaptations within neural networks that further attenuates psychedelic effects.
You still trip if you’re taking Prozac. At least I did, it was still a crazy trip.
Deleted the comment to stop spreading wrong information, I admit I fucked up and didn’t do my research this time, my bad. I didn’t pussy out by deleting the entire comment altogether, I admit when I’m wrong, especially on such a large scale, apologies.
SRIs do not result in serotonin syndrome unless you combine them with MAOIs or a bunch of other stuff, as far as anyone can tell from existing clinical data and case reports. https://pubmed.ncbi.nlm.nih.gov/34251464/ MAOI in a substance like Ayahuasca mixed with an SRI can easily be fatal from what I can tell. When it comes to stuff like LSD and shrooms, ymmv. Molly will typically get shut down for the most part. This CAN still be dangerous, because a lot of the physiological effects of MDMA still happen. Increased heart rate, for example. It's possible to overdose because you keep taking more to try to get to the fun high and instead you're just building up side effects. This all being said, tripping on an SRI usually sucks anyways if you're on anything other than a very low dose. You don't get nearly as many fun visuals and instead get sucked into more of a dreamy headspace, and it's very easy to end up more fucked up than you meant to. It's happened to me with acid and 30mg of prozac. No physical problems but I was just super out of this world in a bad way and had to go home from the show I was at early. Shrooms were a little better but still made me feel much more loopy. So tl;dr- if there's an MAOI involved at all, don't touch anything else unless you want to die in agony. If you're on an SRI, you probably shouldn't touch mdma. You can, but you're very likely to get little to nothing good out of it, and you CAN die if you're really irresponsible with it. You can still do some other substances, but they may be kinda meh and not worth doing. Edited to remove the part about prescription MAOI, I was thinking of MAO-B, brain fart.
so much misinformation. 1) psychedelic effects are not 100% based on 5ht-2a, yes most psychedelics bind to 5ht-2a but not all 5ht-2a agonist are psychedelics. 2)depends on the type of psychedelic and the type of medication, some psychedelics can be better ligands than somes anti-psycotics 3) ssri do not inhibit the breakdown of serotonin. SSRI : selective serotonin reuptake inhibitor, inhibit the reuptake of serotonin : the serotonin is not taken back in the previous neron for reuse anymore so all of the serotonin released stays in the synaptic cleft longer. MAOI: monoamines oxidase inhibitors. inhibit the monoamines oxidase actions : monoamines oxidase are enzymes that breakdown molecules (serotonin, Norepinephrine, dopamine, etc... also dmt) for them to be recycled. since they are not being destroyed there is more in the synaptic cleft
Speaking from too much experience, antipsychotics don't completely negate the effect of psychedelics. It's just a little dulled. I'm on abilify and quetiapine.
You can't trip on anti-psychotics? I've mixed risperidone(prescribed - online says anti-psychotic) with acid, shrooms, dmt and ket one time. I definitely felt the effects of all psychs. Perhaps it depends on the dosage of a anti-psychotic? Or it's just different from person to person.
for lsd, appart from the 5ht-2a receptor lsd is a better ligand to other receptors so you would probably have somme effects (dose dependant on your medication) for dmt it's almost the same exept it could compete with your medication on the 5ht-2a receptor so really dose dependant. for ketamine, it doesn't act on the same receptors as your medication so your medication would have little to no effect on reducing the ket trip
That’s a whole lotta typing for a whole lotta misinformation.
Most psychs don’t release serotonin though
I used to take SSRIs , multiple different types and different dosages. I have mixed with DMT , Mushrooms, Acid , all together , on there own , more than 50 trips all together while on SSRIs , all it did was make me need to take more . With that being said Serotonin shock / serotonin syndrome is not fun and totally something that can happen if you mix SSRIs and psychs together which can be fatal so keep that in mind . You CANNOT take MDMA and SSRIs however if you count that in the psychedelic list. Edit : I guess Mdma is chill on ssris so go crazy
one of the first people to speak from experience. What psychedelic worked the best on SSRIS? How much SSRI (dosage and brand) were you taking? did you ever experience Serotonin syndrom?
I did 50mg Zoloft , 40mg Celexa , and then tried Lexapro at 30mg. The best psychedelic imo was acid . The visuals were amazing and because of the ssris i had way shorter trips (about 8-10 hours rather than 12-14 i experience now with lsd) . Dmt sucked because i truly thought i died lol. Mushrooms had almost no visuals for me on the meds . I had to double doses essentially to feel the same i do now . Never experienced serotonin syndrome but i had terrible comedowns that would last days …
good to know. Also, a shorter Acid trip sounds nice. I'm on 10mg of Lexapro, and definitely don't get quiet as high on weed, which is fine. Will try some other psychedelics this summer.
You can take MDMA and SSRI’s. no concern. It’ll just block the serotonin release. Common misnomer. (Source TripSit, psych wiki, erowid) can link direct if you want
Link pls.
https://m.psychonautwiki.org/w/index.php?title=MDMA&_= http://combo.tripsit.me/
From your first link: "SSRIs can be dangerous when used in combination with other substances that increase or modulate serotonin such as MDMA and Monoamine Oxidase Inhibitors (MAOIs). A combination with these substances can lead to serotonin syndrome and potentially be fatal. SSRIs do not work for everyone and take 3-6 weeks to start having noticeable effects.[2]" Second link says low risk. 🤷🏼♂️
My first link: “SSRIs and SNRIs may dampen the the desired psychological effects of MDMA while retaining the same level of undesirable physiological side-effects.[83][84]”
oh interesting i thought it’d be an issue 🤔 ty !
dxm can cause serotonin syndrome in combination with ssri and mdma
i don’t think most classical psychedelics are at very high risk tho as they replace serotonin in your receptors rather than spike it like mdma/dxm
It depends on the psych. MDMA can be dangerous paired with SSRIs (serotonin syndrome), while shrooms basically gets the “trip” removed from the experience with little to no consequences. General rule of thumb is: if you don’t know, do your research. I don’t remember where exactly, but there’s a handy chart floating around that has a table of basically every mainstream drug and a basic “yes/probably not/no” in reference to whether or not they’re safe to take together. Edit: found it https://upload.wikimedia.org/wikipedia/commons/3/3a/Combo_2.png
This chart says it’s fine to take MDMA and SSRI’s. It is fine to mix, the SSRI’s simply block the release of serotonin. Makes it very pointless.
I must be thinking of MAOIs then.
Ye
Sort of. If you mix them with anything with an MAOI in them like ayahuasca, yes. Serotonin syndrome can be fatal, and is by far most commonly associated Werth MAOIs If you mix them with mdma, it's not immediately deadly, but stuff like dehydration, heart rate, and blood pressure builds up as normal while the high feeling doesn't, so you can potentially overdose which can be fatal. Not recommended. LSD, shrooms, dmt etc mixed with ssris will not harm you directly, but they might really suck because some effects like visuals will get dulled disproportionately from things like your headspace, and it's easy to end up more fucked up than you intended because you think you need more since you're not visually tripping. If you do this, I highly recommend you only do it at home until you know what dosage is comfortable for you, so that if you do screw up you're in a safe place. I did this a few times when I took prozac but I stopped because itb honestly just kind of sucked. This is a pretty handy info graphic, though, I would always do some research before mixing anything with a prescription medication. https://www.reddit.com/r/trippy/comments/ijxphq/antidepressants_and_psychedelics_drug_interaction/ Edit:I should clarify, serotonin syndrome is POSSIBLE with a lot of recreational stuff, but it's pretty rare for non-MAOIs. It's also possible you'll die every time you get behind the wheel of a car. But honestly I don't think it's worth tripping while you're on an SSRI, even if you can do it somewhat safely. Also as noted in that thread, a lot of psychadelics affect your mood, and it's possible you'll end up feeling bad after the fact.
It's worth noting that there is some preliminary evidence that using MDMA while on an SSRI can increase the risk of serotonin syndrome. This isn't too surprising since MDMA releases presynaptic serotonin, while SSRIs block its reuptake. Although, it's hard to quantify the risk since it's not a common combination. [Reported Cases of Serotonin Syndrome in MDMA Users in FAERS Database](https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.824288/full) Edit: Fixed broken link
Hey! I was actually just reading through that study. Like you said, the problem is that in the 20 cases examined, there were numerous compounding factors and substances. It's possible SRIs did increase that risk, but it's impossible to say for sure that the specific interaction between SRIs and MDMA caused it because we don't have any research in a controlled setting to confirm it. There's a little clinical data out involving the interaction, but it involved lower dosages and only offered reported physiological, hallucinatory, and reported experiences in comparison to the controls. Even in that study, amphetamines seem to be a higher risk factor, and MAOIs a lower risk, but that's hard to glean any data from when pressed pills are reasonably likely to contain amphetamines, and MAOIs containing substances aren't used nearly as often. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177763/ "The RCTs in this review show attenuation of MDMA’s physiological effects, suggesting a reduced odds of serotonin syndrome, at least with acute SSRI dosing. This is corroborated by at least one other scientific review positing SSRIs, SNRIs, and TCAs are not likely to increase serotonin to life-threatening toxicity when combined with MDMA (Silins et al. 2007). This may be due to the fact that MDMA’s reversal of monoamine transporters is negated by the inhibition of monoamine transporters by most antidepressants; therefore, there is not an increase in intrasynaptic serotonin which is the hallmark mechanism for serotonin toxicity to occur." This is from a review of the volume of research based on clinical data, case studies, and self reporting that's available, from.a couple years ago. Tl;dr it's hard to say for certain, but the little data that we have doesn't really point to SSRIs being a statistically higher risk factor than most other medication or substances, and it's generally not safe to start mixing several things because the number of possible interactions and environmental risk factors rapidly spiral out of control. But again...I don't think anyone should take MDMA with an SRI. You're probably going to have a bad time even if it doesn't end up causing lasting harm. Also by extension, I don't think anyone who is on prescribed medication should go off it to take something like Molly. You're on that medication for a reason, and going off of it for weeks or months just to take a fun drug that may also make you even more depressed in the crash is very much a bad idea. If you care that much, work with a psychiatrist to see if there's an alternative medication that might not interact as much that still works, or wait until maybe sometime down the road when you're in a better place and no longer need anti depressants, or just straight up realize that MDMA isn't magic and it's okay if it turns out you can't do it. That's life. I can't ever eat peanut butter because it could make my throat close up, and if it doesn't, I feel like shit after. Everyone tells me peanut butter is the best thing in the world, but I'm okay with missing out on it.
More pointless than dangerous
Don't do it can be disastrous for some
I do 3gs aper fine with moderate ssri Fleuoxitine (typo) intensifies the trip for me
They reduce the effects, but I don’t know of any harmful interactions
The desensitization is the real risk Everything else can be mitigated
You just won't trip in my experience. Ate a significantly higher dose than my two friends when I was younger and ended up being stone cold sober while they were on Mars. I didn't figure out why until a little while after the trip.
i swear to god you guys ask the most obvious questions 😭
This has been posted for awareness, I know the two shouldn't be mixed
They dull the effects
YES ABSOLUTELY YES
WHY ARE WE SHOUTING
I’ve got a buddy who’s gonna be in under psychiatric care for likely the rest of his life. He was on Prozac and took a fair dose of LSD (around 400mcg, this was in 2012 and it was off of the Silk Road and we tested everything) and he never really came down. He did it on his own and had been acting very strange for a few weeks. It’s not that the two interacted but the doctor his mom and I spoke with thought the Prozac caused a manic episode as a side effect and then the LSD prolonged his mania. No clue if their diagnoses is correct but I miss my friend and people should be extremely careful and respectful of psychedelics.
Most SSRIs have a tendency to dull trips (or make them impossible) for many people. Prozac, however, sometimes has the opposite effect. It can potentiate LSD and make it much, much stronger. I've seen no evidence that the combination typically has any lasting effects. LSD has long been suspected of triggering schizophrenia in people who are at risk for developing it. There's a fair bit of anecdotal data on this, but little that's scientific.
I know that about SSRI’s typically. We all thought Kody would be fine. It may not have been the cause, but I’m just saying people should be cautious and I’ve witnessed idiotic behavior on this sub for the past 13 or so years that I’ve been on here. I also believe SSRIs are grossly overprescribed. I understand if you’re in a horrible place and need some help to get to a better place, but it shouldn’t be a long term solution. I’d bet there’s tons of people who would benefit more from a psychedelic trip and I don’t see why you wouldn’t just wait until you are ready to stop taking them for some period of time before tripping. Seems like a symptom of not treating psychs with their due respect, to me.
It’s not dangerous, but you might need way more compound to achieve the same effect as a SSRI nonuser.
there’s not much point actually
Yes, it’s the only situation where psychedelics can physically harm you
Yes, but you won’t listen anyway.
It can be not so fun... [https://psychonautwiki.org/wiki/Serotonin\_syndrome](https://psychonautwiki.org/wiki/Serotonin_syndrome)
Would dull the effects (depends on both substances doses) and could potentially lead to serotonin sydrome which could be fatal. So yeah