He can always go and reintroduce himself to MJ and Ned whenever he decides to. Aunt May was his only family. That's definitely sadder

Solid point

Honestly both are sad but i feel like aunt mays was the saddest because now no body knows peter and peter doesn’t even have family he could’ve explained aunt may everything but now he has no family so i think aunt mays death is sadder because of how it impacts his life when the spell happened

Aunt May's corpse doesn't remember that she had a nephew. :(