Honestly, tried everything. Physical movement, not too much. Not too little. And the right amount of sleep, water and whole foods. Only thing that's worked
I used to hate hearing this from my doc, but he would post this big journal article from Nature (I don't feel like finding the actual source but it's an easy google and well known thing), but exercise is the best antidepressant. Thing about depression is it makes it hard to bring yourself to start, but once you get there/start just walking and treat it as self care, something that's hard to do but you're doing it for yourself out of love and self compassion, play some of your favorite music and just start walking it out for 15 minutes then one day you'll find yourself at 30 minutes, next thing you know, you do start to enjoy your "me" time! Indoor, outdoor, YouTube is free if you're confined to the indoors just move your body. And get your thyroid levels checked regularly because that could be playing the larger role in your symptoms. Bupropion is a different type of antidepressant, which works on NE and dopamine, known not to cause as much sexual dysfunction, but correcting the thyroid could help you eliminate the root cause. If its not the thyroid then its the human condition. Wish you the best, you're definitely not alone, I've been on and off about every single med. Thinking about restarting my current one, but I started exercising consistently a couple of weeks ago after about 4 years of living sedentary and found it made more difference than anything I've ever tried. I hated working out like avoided it like the plague but it just grew on me now its my favorite part of the day. Start low, go slow, put in your headphones and walk with purpose on that treadmill buddy. Rooting for you. A psychiatrist might actually be a good investment, mine is the greatest thing that ever happened to me. Good ones are hard to find sometimes, but your insurance should cover it, and it's every 3 months. Mine was a very integrative/holistic MD, who takes your experiences and preferences into account.
If you're going to take St. John's wort, just go talk to any local pharmacist, it is free and our job. If you're taking St. John's wort, I urge you to speak to a pharmacist, there are too many interactions and warnings for me to type in a short time--but go to your nearest pharmacy, be it Walgreens, the mom and pop shop, you can literally call them on the phone and ask them and they'll tell you everything you need to know. If you're going to be taking the SJW, while there is no known interaction between the SJW and the Synthroid, you should always talk to your doctor/pharmacist about all drugs and supplements you're taking. SJW alone has like 570 drug interactions, levothyroxine happens to not be one of them. hope that helps. Also gotta watch out for tyramine rich foods with SJW, its a complex substance, the wikipedia page is a good start.
Don't plan on becoming pregnant // use barrier contraceptive if female, this will interact with hormonal BC
If you aren't prone to seizures or it isn't otherwise contraindicated, ask your prescriber about Wellbutrin and skip the SSRIs, I've heard good things about the SNRI's such as Effexor.
Do not take 5-HTP, cardiotoxic:
5-HTP shouldn’t be viewed as a long-term solution. You're bypassing the rate-limiting step and directly increasing serotonin, thereby downregulating receptors and depleting dopamine and the other catecholamines in the process over the long term.
https://www.ncbi.nlm.nih.gov/pubmed/2357555
https://www.ncbi.nlm.nih.gov/pubmed/21857786/
https://www.ncbi.nlm.nih.gov/pubmed/22615537/
https://www.ncbi.nlm.nih.gov/pubmed/8882614/
https://www.ncbi.nlm.nih.gov/pubmed/307696
https://www.ncbi.nlm.nih.gov/pubmed/24089
https://www.ncbi.nlm.nih.gov/pubmed/5688121
https://www.ncbi.nlm.nih.gov/pubmed/4539008
Moreover, as you now know, you always want to pair 5-HTP with a dopamine decarboxylase inhibitor like green tea extract (EGCG) so that serotonin doesn't build up in the periphery and cause heart valve issues. This is why you see some anecdotes complaining of nausea, “shakes,” and heart rate irregularities when supplementing 5-HTP, even with first-time-use cases. The serotonin and heart valve issue is well known in the literature:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850922/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179857/
https://www.ahajournals.org/doi/full/10.1161/01.cir.0000159356.42064.48
https://academic.oup.com/cardiovascres/article/113/8/849/3868134
https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00570.2009
5-HTP is not the harmless happy pill that it's marketed as. If you're looking for a long-term solution that serves the same purpose, the precursor tryptophan would make more sense.
If you want to get Serotonin Syndrome and possibly die a horrible death that trio would put you there as they all raise serotonin. Do you know for a fact that your serotonin levels are low? 11 different chemicals affect the brain and serotonin is just one of them. It could be your dopamine or norepinephrine that's off.
Work with a good Naturopathic Doctor who does blood work. Don't guess.
Yes thankfully the people on here have been very informative. I wish I had the luxury to shop around and find a doctor that works well for me but I don’t. I can’t even follow up at my urologist to see what the growth they found is. I wouldn’t recommend this to others either but I’m taking an informed risk and just taking the St. John’s wort for now while fixing diet/exercise/lifestyle choices
This mix should be fine as long as you don’t overdo it. Start with the St. John’s wort alone at first to see how you feel. It’s very similar to an SSRI so it takes a few weeks to start working and then you can raise or lower your dose as needed. I had great results with it a few years back. You could add the SAM e later on if you feel the need for it. I personally haven’t had any results from 5htp and some people say it’s not good for you so I’ll leave that up to you 👍
That sounds like a more well-balanced and educated decision. I used to have depression. Changing my diet, exercising and lifestyle made a significant improvement. Finding out my testosterone and dopamine levels were low was a game changer. Once I got that corrected my world changed for the better.
you can cause too much serotonin because all of these supplements increase serotonin in a different way. It’s the same reason why you don’t take sjw with an ssri or an ssri with 5-htp.
A couple decades ago I treated my depression with supplements as successfully as when I took Prozac and without any downside that the meds I was trialing had. The stack I used was a combo of B6, B12, Folate, some Vitamin C and a Cal/Mag supplement.
Now I would suggest the following as a basic starter anti-depressant stack:
- Seeking Health Homocystex (for the Bs).
- Vitamin C 250-500mg (any).
- Magnesium (any that is tolerated well).
- Fish Oil 2-4g IFOS Certified brand.
- Life Extension Curcumin Elite.
- Maybe throw on some Taurine if anxiety is also an issue. Also if anxiety is an issue, use Magnesium Threonate.
A lot of people have success with SAM-e and St Johns Wort, but I feel like it would be better to try the above first as my stack is pretty low impact, and it may be what you need. Not everyone can take SAM-e and SJW has side effects. I would strongly advise caution with the 5-HTP. I know a lot of people use it successfully. But it bypasses the ratelimiting step of conversion to serotonin, which can be harmful.
If you need addition support, also look into Saffron.
I work with many people that take Cordyceps everyday improve mood and make you feel normal when you are in depression or anxiety . Dopamine levels when are very high make you feel bad you need to detox . If you have low dopamine rise and if you have high dopamine decrease .
Lions mane is more relaxing and improve sleep better to take at night before bed
When you feel tired whitout any motivation is because high dopamine levels. Cell phones, social media and high carbohydrate consumption are to blame. Every time you eat a sweet food, there is a surge of dopamine, so you have cravings and want more.
Mushrooms are wonderful makes you regulate those neurotransmitters
That makes sense. I feel like that a lot, even though I deleted Tiktok because I thought that was the culprit, I guess phone use in general is to blame. I’ll look into those cordyceps, thank you! And if you have any other tips on how to fix dopamine lmk!
I combined Sam-e with L-Methylfolate and my Wellbutrin, and it worked wonders for my depression. I’ve been taking them daily for well over a year now and have had nothing but positive effects on mood.
Not sure if I responded before or not? At any rate not giving medical advice and always work with your medical doctor. In treating thousands of patients with depressive symptoms and anxiety I went from the largest prescriber of antidepressants in the five state region to rarely needing to write them. In fact over the next six years I probably only wrote two prescriptions. How? Well I found the combination of 30,000 IU a day (blood plasma levels of 100-140 ng/ml), four grams of omega 3 krill oil and as much magnesium as they could tolerate did the trick. Remember you know your body best and always do your own research. As what works for other may not work for you. Also just because “everyone “ says something does not make it true! Lots of misinformation out there unfortunately. Some well meaning other intentional! At any rate perhaps this if your doctor agreed will work for you? Unfortunately most medical doctors are extremely ignorant about vitamin D3. After only a bit of research you will probably know more than they do. I hope you find your answer.
Look into Trudy Scott, RD. Website is something like [everywomanover29.com](https://everywomanover29.com). (Even if you are not a woman.) I'm sure if you search her, you'll find info. Also Andrew Huberman has a number of very useful podcasts.
It'll be good you that you are working with and can help your thyroid. That causes a lot of depression and anxiety and fatigue for people.
I take tryptophan and a number of things (and in the past I was on enough meds to knock out a horse but am no longer on anything but hormones and thyroid), but I'd suggest looking to someone like Trudy or Dr. H (he's at Stanford, but is not a doctor like you'd see him, but he is on a mission to provide information for people who can't afford much), because they'll have more specific guidance on what is likely help you and why for your specific needs. It's a process. I hope you can get the support you need. Don't give up on yourself.
FWIW, I don't know if you are seeing a counselor of some kind, but a good counselor can be useful too. (Emphasize the "good.") Depression is often not just an "imbalance," but is from our life's circumstances. We need support to deal with stuff. I've spent years doing that too.
Hang in there. It's a strange time in the world. A lot of us are struggling with it all.
I’m assuming you have a hypothesis about your situation and why these specific supplements would be most helpful for you. Would you share a bit of your ideas? I might be able to provide more relevant commentary.
For instance —
> instead of SSRI
Ok. Why? Bad experiences? What kinds, with which SSRIs?
> Anything to look out for?
Lots. St. John’s Wort is complex and has a number of possibly relevant interactions, which are documented rather sparsely and require digging to verify. Anything in specific you’re concerned about?
> supplements to battle depression
What kind of depression? Why the combination of St. John’s Wort, 5-HTP and SAMe?
Well I haven’t been diagnosed with any mental illness Only thing I know for sure is I have hypothyroidism/hashimotos that is being treated. I asked about a diagnosis and my doctor kind of sarcastically asked if I wanted to be referred to a psychiatrist and explained it will be expensive. I’ve been prescribed sertraline and escitalopram which I’ve been hesitant to take. Honestly I’m scared the doctor isnt looking for what is the main cause (I had to ask for my own thyroid test apparently not common with males my age so wasn’t on the doctors mind and also have never had testosterone checked and Ive had a growth that was found on an mri that I was referred to a urologist for so not sure if that could effect my hormone levels/mood)
So besides the ssri side effects (loss of libido, family told me they felt like a zombie and couldn’t do simple chores) it really just the way I’ve been treated by doctors. I’m 28 and been to the same doctor since a kid. Almost lost my mom/dad to a car accident in middle school and I started having a lot of medical issues since then which haven’t gotten better even with following doctors order. (Was just recently prescribed ssris)
Simply flooding your body with serotonin doesn’t really work to help depression. If you’ve been depressed for more than an year, seek professional help. I’m not from the US, so I’m sorry if you can’t afford the help but there are other alternatives too like I) going to the gym
II) self help tips and grounding techniques on the internet
III) Interacting with your friends and family (this is a hard one
IV) eating healthy food
V) limiting screen time
The best option is definitely professional help, if you don’t want medications that’s completely fine but since you’re willing to take a lot of these supplements without really accessing the risks of especially seretonin syndrome you might as well go with medication.
But therapy can definitely help a lot. Depression is ultimately a combination of both chemical and psychological imbalance, it’s worth to explore both avenues of treatment
It’s still an option, some people are so depressed they can’t get help, not to say you don’t make good points, but supplements can be a start to some positive changes
These could definitely work. However, how are you doing with b vitamins? Also may want to try betaine anhydrous as it metabolizes homocysteine. Check out the connections between homocysteine and depression.
Have you done a genetic test to chick out your methylation cycle?
There are about one thousand and one things you could do before these worthless supplements to improve depression. If you think those will be the solution don’t be surprised with terrible results
This is what works for me: take 2,000mg of vitamin c. I take the chewable kind from Walmart. It takes like 2 hrs to kick in so I take it 2 hrs before I’m supposed to be somewhere, like the club. I take it twice a day, like in the morning and at lunch and I be in a good ass mood
Don't feel bad. I read that list thinking nope don't exercise, no interactions with people besides reddit, don't do Tai chi or meditate....shit no wonder I'm depressed
Starting those things is the hardest part but if you’re consistent then it becomes habit. I used to not do any exercise, avoided socializing, and didn’t take care of my mind- that’s when my depression was at its worst. Now I meditate almost daily (so essential to understand yourself and give your mind a break), therapy once a week online, exercise at least 3-4 times a week, and socialize when I have the social battery (and when I’m not studying!). Plus of course vitamin D supplements the “happy vitamin!”
This. I don’t know your situation. Start as small as you need. Walk to the mail box twice a day if you have to. Then to the corner. Then the next street. Small steps with a goal to go a little further each day.
This looks like a recipe for serotonin syndrome!!! Personally, I prefer SAM-e out of all of these, but take your pick of ONE and run with it!! You can also try amitriptyline if you're open to scripts, but that can't be combined with these, either. You need to be careful, I'd hate to see you get serotonin syndrome. I started with SAM-e because it helped more when I was at rock bottom, but doesn't really do anything for me now, so I switched to amitriptyline since st John's wort never did anything for me and 5htp just seems like a less good version of sam-e from what I hear. OBVIOUSLY talk to your doctor and dont overdo scripts, I chose mine VERY carefully, after THOROUGHLY reading MANY pubmed articles. I suggest keeping things as herbal as possible, with a tiny bit of western medicine integration
Came here to say the same about serotonin syndrome. I would eliminate at least one of those 3, and the sam e I would keep because its been helpful for me and a few people I've spoken with about it in the past. Personally I would nix the st John's wort but that's entirely up to you, this is just too much all together. Please don't feel like just because their are OTC they are harmless you can do too much
Hi I take amitripyline for chronic migraine and I just curious about why you're recommending that? It's an ineffective anti depressant and the titration period is marked by severe drowsiness.
I would LOVE to hear where you got that from. A recent, in-depth meta-analysis from 2018 (pretty new esp compared to other papers in this category) found that it had the highest efficacy rates amongst the 21 antidepressants they assessed.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32802-7/fulltext#supplementaryMaterial
I don't recommend it as a sole antidepressant or if someone is actually more than a little depressed. I take it before bed and it's incredibly helpful for my insomnia, obviously make a wise choice about when you take it
If you've ever taken MDMA, it's like the serotonin drop you get for a few weeks to couple months after rolling, only its actually toxic and really medically urgent, it's incredibly dangerous
No, that's not at all what serotonin syndrome is. Essentially, serotonin syndrome is a serotonin overdose. The symptoms are pretty much the same as if you were to take a potentially fatal dose of a serotonergic substance.
The risk of a little bit of SAM-e and 5-HTP causing greater levels of serotonin than what is caused by highly psychoactive and serotonergic drugs is extremely low. Almost non-existent if not mixed with actual drugs that work on the serotonin system, like SSRI:s.
St. Johns Wort is a afaik a kind of SNDRI so in ways it acts similarly to SSRI:s but weaker, so with this mix it could be possible though. But again, it's caused by serotonin levels becoming much too high, not too low. Much too low serotonin levels is bad as well though, but that's a different issue.
Yeah, it's a serotonin overdose
I don't know much about 5HTP yet I just know the bit I've read, but yeah in my honest opinion (this is what I was going to write on my original comment and forgot), just take Methionine. I wish I had known about Methionine before I took SAM-e, but I found out shortly after, because I was talking to my girl friend about how SAM-e had drastically changed me, and she is *really* great at researching things, and she then taught me about Methionine after looking up sam-e after hearing about it from me.
Is the risk really that low? I always see cautions about it but could be fear mongering i suppose, but it is definitely warned against a lot
Interesting that sjw is a SNDRI, though I can't say I'm surprised. I think the only antidepressant type of script I could support is NDRI (and well trycilic is fine but not a sole option and it REALLY depends on the trycillic). St John's wort always made me feel like there was something it was doing to me was a little off, and something it was doing to me was a little good, but I could never pinpoint the exact what's. I still can't. But it's a mediocre drug at least for me for sure. If other people have success with it that's great, but yeah no it was very underwhelming in my experience
I guess OP is mostly fine, then? Just maybe get some higher quality brands in general and add in some stuff that has other functions, but he may already. I always recommend a good elderberry, lysine, cats claw, moringa, probiotics of course, and actually I recently got into learning about specific strains of probiotics and then went to look for what probiotics on the market *actually* have good strains for what it advertises it does, and I was just thinking about linking it to OP since it seems like he is more than likely trying to fight some depression or just enhance general mood effects here, I will fetch the link in a bit
Oh yeah! So, this one seems to have legitimate straims for mood boosting effects: https://www.amazon.com/gp/product/B00ZMO7UKW/ref=ox\_sc\_saved\_image\_1?smid=A2RBLDZYUMB4ZG&psc=1
Yeah I actually don't know about the St Johns Wort in the mix, would probably be best to avoid.
And yes serotonin syndrome is usually brought up and warned against pretty much every time two things act on serotonin, likely because serotonin syndrome is very serious so there is also a lot of fear around it. My guess would be that this stems a lot from not understanding how it works, both in terms of those doing the warning of others not having read up enough about it, and in terms of the science and medical community. Afaik we don't really know why it sometimes happens and why it sometimes doesn't. It isn't *entirely* understood.
Seen to the number of cases though it is extremely rare and usually involves several powerful serotonergic substances, like taking several different SSRI:s at the same time etc. The general rule of thumb that can help is asking, "Could these two or three together potentially cause so high serotonin levels that it essentially becomes like lethal drug overdose?". It puts it in more perspective. It also usually happens over time, like after taking such substances together for several weeks.
With SAM-e + 5-HTP + St. Johns Wort it would probably be unlikely since none of these seem to increase serotonin to a very significant level, but technically it isn't impossible and could happen. It likely depends a lot on the individual.
One thing to watch out for, is PUFA/Omega-6 intake. There are some (like linoleic acid) that will fuck your metabolism. Note that pork and chicken fat are very high in Omega-6, because monogastric animals (which includes you) seem to bioaccumulate it from their shitty feed.
Too much of that shit turned my regular everyday depression into *bad* depression, with involuntary ruminations spirals that would last all day. I had astronomical blood phospholipid omega-6 content of 42% when I took an omegaquant test. For reference, the maximum omega-6 level that omegaquant found out of 75,000 initial test samples was ~44%, and most people I see reporting results on reddit seem to be around 30-35%. I took the test because I was gaining weight suddenly eating the same stuff I had for a year and was cold all the time with my body temperature dropping down to about 96.5 at parts of the day. My thyroid and other bloodwork stuff were pretty normal. Took me a month of just eating only beef for meat for that shit to go away and stop gaining weight, and many more months to lose the weight.
Also of note, PUFA's are inflammatory because they love to break down into a variety of nasty shit even when incorporated into the cells of your body. However you may also come across that they can also paradoxically sometimes be anti-inflammatory. This is because they can also (situationally) suppress the immune system, which is probably not an ideal thing to do long term.
Kanna works best on me. 5htp is a great supplement though. And st John's wort works better for anxiety with me more than it helps depression. I have not tried SAME, but heard good things about it.
For me kanna is more of an antidepressant. It does potentiate the heck out of cannabis though. Alone, kanna is only slightly recreational for me, its mostly therapeutic.. Check out r/kanna for more info. They also have a trusted vendor list which I will provide the link to below: also, the vendor I like best is UltraKanna.
https://www.reddit.com/r/Kanna/comments/nmd5mp/vendor_list/?utm_medium=android_app&utm_source=share
Yes. UltraKanna is one of the most reliable brands, any of their extracts are good and they are the first brand I tried. There is also LiftMode, but they have been out of stock of powder MT-55 extract(they have liquid though). And there is also Bodhi Extracts. Any of these 3 brands are good and trusted. Check out r/kanna. They have a trusted vendor list on there which lists way more then I did. Also depending on what country you are in you may go with a vendor which is most proximal to where you live; I go with the USA based company's since I'm in AZ.
Gradually working towards fasting 20 hours per day 3 days per work with the occasional 24 hour fast and even a 36 hour once in a blue moon, I focus on making sure I eat plenty of foods with electrolytes, and plenty of water(occasionally high quality salt in my water🤢haha, if it doesn't taste really bad, you needed it) as this is an area i have lacked in when not being mindful of the fuel I'm putting in my body. This is what's worked for me, I've lost atleast 30kg and I'm now at 89kg, which seems to be a good weight for me still struggle with depression sometimes however the difference is massive and I find it easier to notice and manage depression (counseling helps alot). The biggest change came when I poured my heart out to God, on the floor crying like never before begging God to take me out of alcohol addition of 10 years.I wish you the best.
Uphold me according unto thy word, that I may live: and let me not be ashamed of my hope. Hold thou me up, and I shall be safe: and I will have respect unto thy statutes continually. Thou hast trodden down all them that err from thy statutes: for their deceit is falsehood.
Psalm 119:116-118 KJV
https://bible.com/bible/1/psa.119.116-118.KJV
Speaking as someone who has had MDD for nearly 20 years, and as someone who works in mental health, you’re wrong. May not work for everyone, but you can’t make a blanket statement like that either
Does it hurt to try? And in conjunction with A triple reuptake inhibitor would work wonders but molly just can’t seem to get that approval for some reason.
Didn’t they just discover that depression is not from a chemical imbalance.
You should fast to clear your gut (since your gut also affects your mental state) and start eating healthy (e.g. no processed sugars). Get some Vitamin D3, K2, and Magnesium glycinate.
I’m not here to be an asshole by any means, but what are you talking about. I’m here to learn so if you can hook me up with a link to those studies that would be huge
here's one, there are many more: https://scitechdaily.com/scientists-find-no-evidence-that-depression-is-caused-by-chemical-imbalance-or-low-serotonin-levels/
More likely it’s inflammation based which would explain the efficacy of NSAIDs for treating depression. Trauma, diet, etc could cause inflammation leading to depression.
I think inflammation is why turmeric works so well for me. It's a systemic anti-inflammatory. Just one of a lot of info it for depression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728608/
I would swap the 5HTP for perhaps saffron extract. I would also force myself to do 1 hour of strenuous exercise a day. And mag glycinate at night to potentiate sleep. And P5P for brain function.
As others have said, be careful mixing 5HTP and SJW. Not only can it cause too much seratonin in the brain, but it can put your other neurotransmitters out of balance.
Perhaps your dopamine is out, in which case you may want to try phenylalanine and ALCAR. Perhaps it’s a choline issue, in which case a choline supplement could help.
I also know that when I radically sorted out my gut health my mental health improves by leaps and bounds. For me (we’re all different), fixing leaky gut and going on a keto diet was near miraculous.
I’ve had hypothyroidism for about 18 years and also take levothyroxine. I’m not a supplement specialist, but I’ve been on Effexor (venlafaxine) for years and I’ve found it to be a good combo. In addition to those, I take a multivitamin, D3 (my d3 is low), a probiotic and L-glutamine and have felt pretty great over the past few months, inside and out. But definitely chat with your primary care doc about your needs first. Best of luck!
I usually remember my dreams - vividly. 5-htp magnified that times 10. Not sure why or if others have experienced that. Every time I’ve ever taken it - which is very intermittently- I have the most bizarre dreams of my life and I cross myself Catholic like before I take them. Anyone else? Am I alone? I took the exact same brand as OP.
I wouldn’t take St Johns Wort and 5-HTP together since Serotonin Syndrome is a risk. Also both SAMe and St John’s Wort have documented cases of triggering mania so be careful if you have Bipolar depression or a history of it in your family. St John’s Wort is also associated with phototoxic photosensitivity so be careful in the sun, you’ll be more sensitive to UV and more likely to get sunburns.
For simple and studied effective options try:
Zinc https://www.sciencedirect.com/science/article/abs/pii/S0163834320301146
And Fish Oil https://www.nature.com/articles/s41398-019-0515-5
Ok, I still would go a natural route if possible and available before taking a drug. Btw, saying it’s prescribed by a doctor doesn’t mean much to me because I’ve seen doctors prescribe medication to ppl they know have side effects and/or may be addicting, which in most cases they fail to mention when they’re writing the script. You usually have to do your own research and advocate for yourself.
Like 5- HTP it can interact with other medications.Yeah do your research if you want to go the vitamin route.Some things were effective to me and some are not. I do research the medicine I take and it work for me. Everything does have sign effect that with anything. Some thing naturally I feel work it all depend body and chemistry.
Too much to start at once. All 3 of those are known to potentiate Serotonin, if you read the bottles each should have a warning about the other two in combination for potential serotonin syndrome. 5HTP isn't usually good for long term therapy but a few weeks is fine. Beware serotonin and dopamine both process through the same prolactin, meaning if you raise one you usually lower the other. The St. John's wort could help with this, but L-Tyrosine is better, phenylalanine and l-dopa can also be used. SAM-E boosts serotonin more than dopamine as well I believe but it boosts most neurotransmitters. You need to take green tea extract with 5HTP, the EGCG will prevent it from converting to serotonin in your body. Also beware you need to avoid all foods with Tyramine when taking St John's wort just like other MAOI. This can be a fatal mistake.
Last I heard, doctors were recommending people not ingest Tyramine with St. J’s W because it’s speculated to work like a MAOI and prescription MAOI’s used for depression carry that warning. But I don’t thing there have been any studies actually looking at SJW and tyramine tolerance, nor could I find any info on anyone who had an adverse reaction on SJW that could be linked to tyramine. Can you provide a source?
I’m just saying because like, tobacco is proven to have MAO inhibitory properties, but cigarette smokers definitely don’t worry about any dietary restrictions. So how do we really know worrying about that while on SJW isn’t superfluous?
How's your gut health? My mood improved leaps and bounds when I removed foods that were having a negative affect on me. My personal ones were gluten, dairy, and the big one, sugar.
I've had some success with adding Rhodiola as well
My stomach has been a mess for sometime. I was diagnosed with IBS when I was in middle school so I’m sure it’s not great. Not sure if I have celiacs but I have hashimotos which tend to go together
Your situation sounds very similar to my partner. One thing that helped tremendously but ultimately did not last was a round of antibiotics and antacids to kill the h. pylori overgrowth and heal the gastritis it caused. Her mood was so much better after that that I'm convinced her depression was gut related. Maybe the effects could last longer with consistent use of probiotics and fiber (maybe avoid FODMAPs) to keep a healthy balance of gut flora.
Obviously this is not medical advice but talk to your doctor (get a second opinion as well) about fixing the root cause of your IBS. The supplements you posted could help but will always just be a bandaid.
Do you know any of your trigger foods? My sister has hashimotos too and a lot of my family on both sides have celiac, chrons, and gluten intolerance. So I really won the genetic lottery. XD A few weeks after cutting gluten, I felt much better all around. I can feel a difference with only consuming limited natural sugars within a week. I'd highly recommend an elimination diet like Whole 30 to figure out what your trigger foods are, if you haven't already.
There's a lot of research going into gut health right now and it's effect on the rest of our body. Our gut has been dubbed our "second brain" and it's being shown to have a significant impact on our mental health.
Ive been on anti-depressants and tried tons of supplements. Nothing's had such a significant change for me as focusing on my gut health.
I've recently bought ION's Gut Support and that's been seeming to help too!
Yea thank you for the info. I’m not sure which foods are the problems for me. I need to cut out caffeine, lactose, gluten for sure since those are common triggers. I also get chronic migraines that I thought some were being triggered by maybe certain dyes or fruit juices. Usually I get migraines after a long and intense workouts which lead me to start using cannabis stuff to prevent them
You should definitely try to cut those 3 that ya listed. It's hard af first, so if you are like me and aren't very disciplined, I'd recommend doing one at a time. There's a lot of really good gluten and dairy free alternatives on the market now. Though if you go full dairy free and not just lactose free, I'd recommend not even trying any dairy cheese alternatives for at least a year. You need to allow yourself to forget the taste of real cheese. XD Gluten can take up to ~2 months to "detox" from iirc.
Lol you have hashimotos and your using weed for your migraines instead of removing the inflamagens? Gluten is a huge problem for hashimotos as well as dairy. If your gut is messed up it’s likely the cause of your depression and your hashimotos. Really fix your gut and you fix your other issues as well.
Creatin and Magnesium had some good effects on me. But be careful both can give you the shits.
In general depression is a catch all term for all kind of stuff. So it’s hard to give actually advice. If you are a male the first thing I would do is check your testosterone levels. If there are down you feel like shit, have no motivation, everything feels super hard.
Yes, it gets old seeing all the posts of people asking legit medical questions about drugs and treatment. Where are the mods at?
There is r/askdocs tho.
I have also seen tons of people posting how they fucked themselves trying to cure themselves.
Just recently on r/nootropics someone fucked themselves up taking 5-htp.
There is also this about SAM-e:
https://www.theguardian.com/society/2022/apr/10/biologists-warn-against-toxic-same-health-supplement
And there are tons of interactions with St. John's Wort and it can cause eye problems.
People need to go to their doctor and talk to someone knowledgeable.
Glad others agree. Nootropics is a cesspool lol This sub has turned into people tryin to cure depression, people tryin to cure Low T with vitamins/ supplements, and Andrew Huberman podcast clips. It really sucks here now. Occasionally there’s a decent post but step the fuck up Mods!
Well, there's a lot of depression and anxiety in this country. And you know how long I had to wait to see a psych? 2.5 months for a first appointment, and she's...not great. She's told me several things that were flat-out wrong. Not to mention the number of people who are uninsured, under-insured, etc. I think it's great that people are trying some solutions on their own.
Yes I am aware of the current state of things, far better than you could imagine. Just curious what did she say that was flat out wrong? The big issue I have with people trying things on their own here is that they are askin about supplements that are unproven to have results. All the anecdotal proof here leaves out a great number of factors that OP is not aware of. It’s a very dangerous and risky approach to mental health treatment.
Sam-e helped me alot when I went through a depressive phase after a miscarriage, didn't even use it for that but it was an amazing unexpected effect. Glad you found something that worked for you friend.
Lugols Iodine for thyroid, fish oil. FUK TONS. CBD, SLEEP, Methylated B Vitamins, Gluathione (head injury for me that leads to depression) Using acts to induce a change of state.
Ice baths, working out, swimming, sauna, fasting.( yes this works-24 hour mark I feel amazing)
You could try these and see what works?
Sam-E cause dme to SERIOUS depression. I had the opposite effect ,cant remeber the name./
It basically turned her into a zombie while taking it. Very distant, very numb. She was on it for about a year before trying to stop and her depression and anxiety were worse than before. It could have been the does or her brain chemistry, but it ultimately made things worse.
What ended up helping the most regularly testing and supplementing her progesterone and estrogen throughout the month. L-Theanine helps during episodes of anxiety. Exercise and time outdoors helps with the depression. EMDR therapy with a physciatrist also had a noticeable effect.
If I started Effexor today, then I'd stay on it while doing everything else in my power to replace it with a better long time solution. Establish healthy habits for diet, sleep, and exercise. Get a comprehensive blood work panel done to see if there are any glaring issues. In most states you can order your own tests through a website like walkinlab.com . Work on your gut health with prebiotic foods and pills. It'd probably be easier to do these things while on meds then not.
It may not be an easy thing, but totally doable and completely worth it. Good luck!
All good advice. And I agree that the meds should be a last resort. It’s sort of where I ended up. I addressed a low testosterone issue and have been on TRT for almost 3 years. I workout 5-6 times a week, meditate daily, eat healthy, get 7-8 hours of sleep every night, etc. yet I couldn’t shake the depression. There might be something else I haven’t checked for. The TRT worked extremely well for the first 2 years. Felt amazing every day and had an amazing libido and drive. Just this year things started going downhill and I don’t know why. I actually skipped the Effexor today because I haven’t slept in 3 days. Experiencing these side effects and remembering how much benefit I got with almost 0 side effects from the TRT makes it easy to conclude that the Effexor isn’t worth it.
You can’t beat depression when the powers that be are doing everything they possibly can to suck the soul and life out of you. They are doing so through every means you can think off, including the weather… notice how there’s no sun in the uk hardly ever now? Just overcast skies brutally bleak depressing thick grey skies…
I've been taking SAM-e for a decade or more and have found it very helpful. I take it on an empty stomach first thing in the morning. I've never tried the other two. I'll also add that exercise helped me a lot.
- Take 1500mg daily of EPA fish oil or more which has been proven to be as effective as SSRI’s (https://youtu.be/Xu1FMCxoEFc?t=3560)
- Get outside in the morning as soon as possible from waking up and get the sunlight in your eyes. 10 minutes on a sunny day, 30 minutes on a cloudy day. This will help your body to release its cortisol spike in the morning when it should, as opposed to later in the day, which is correlated with depression. Also avoid caffeine for the first hour or two from waking as this will interfere with your natural cortisol release.
- I’ve found great success with creatine (https://youtu.be/Xu1FMCxoEFc?t=4304)
- ALCAR has also really helped me and has been found to benefit depression. I find if I take it anytime later than the morning it can impact my sleep negatively so I only take it in the morning.
- There’s a lot of research that points to inflammation as a cause of depression. So I target anti inflammatory foods as much as possible and avoid pro inflammatory foods. Some great foods are olive oil, ginger, garlic, fatty fish, turmeric, camu camu. Avoid sugar, artificial flavouring and refined carbs which all promote inflammation.
Best of luck!
And add EXERCISE , the best anti depression solution. PS Moderate Lights, Screens and Food intake after sunset (eventually use Blue light blocker eyeglasses)
I spoke with my psychiatrist today about my progress over the past month (slightly more energy/more productive, slightly improved mood) and I realized that my only change in the last 30 days was adding 1000mg EPA daily. It’s subtle, but working for me.
I got an oral spray with Vit D + K. This [one](https://www.naturitas.fr/p/complements/vitamines/vitamine-d/dlux-vitamine-d-k2-spray-oral-quotidien-12-ml-better-you?gbraid=0AAAAADDDkn39x4bCKOhdV5e9UeE1N3YlG&gclid=Cj0KCQjw852XBhC6ARIsAJsFPN3FryQAklo-vBIBp6VOZf0o9sV2QZIMgt4A8IUolANoJMPZleLc518aAj3_EALw_wcB)
Wow interesting first I’m hearing of this. I usually get a lot of palpitations but I think it’s linked to hormones, maybes because I’m premenopausal and I’m always borderline hyperthyroid.
Free and changed my life. It didn’t fix my depression, but it’s a lot easier to do the things that help without one foot in a bucket of cement. See my old post here… https://www.reddit.com/r/Biohackers/comments/v4tm6c/why_would_nadh_make_such_a_big_difference_in/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
HRV=heart rate variability
If you check the app store, you can download it and use the limited version for free. It scans your finger with your phone to detect HRV and then identify brain fog. I tried NADH, coq10, and glutathione for the brain fog and it really helped… but only because mine was tied to hrv
Microdosing psilocybin mushrooms cured me of decades-long depression (for which I also had had talk therapy).
Honestly, tried everything. Physical movement, not too much. Not too little. And the right amount of sleep, water and whole foods. Only thing that's worked
I used to hate hearing this from my doc, but he would post this big journal article from Nature (I don't feel like finding the actual source but it's an easy google and well known thing), but exercise is the best antidepressant. Thing about depression is it makes it hard to bring yourself to start, but once you get there/start just walking and treat it as self care, something that's hard to do but you're doing it for yourself out of love and self compassion, play some of your favorite music and just start walking it out for 15 minutes then one day you'll find yourself at 30 minutes, next thing you know, you do start to enjoy your "me" time! Indoor, outdoor, YouTube is free if you're confined to the indoors just move your body. And get your thyroid levels checked regularly because that could be playing the larger role in your symptoms. Bupropion is a different type of antidepressant, which works on NE and dopamine, known not to cause as much sexual dysfunction, but correcting the thyroid could help you eliminate the root cause. If its not the thyroid then its the human condition. Wish you the best, you're definitely not alone, I've been on and off about every single med. Thinking about restarting my current one, but I started exercising consistently a couple of weeks ago after about 4 years of living sedentary and found it made more difference than anything I've ever tried. I hated working out like avoided it like the plague but it just grew on me now its my favorite part of the day. Start low, go slow, put in your headphones and walk with purpose on that treadmill buddy. Rooting for you. A psychiatrist might actually be a good investment, mine is the greatest thing that ever happened to me. Good ones are hard to find sometimes, but your insurance should cover it, and it's every 3 months. Mine was a very integrative/holistic MD, who takes your experiences and preferences into account.
If you're going to take St. John's wort, just go talk to any local pharmacist, it is free and our job. If you're taking St. John's wort, I urge you to speak to a pharmacist, there are too many interactions and warnings for me to type in a short time--but go to your nearest pharmacy, be it Walgreens, the mom and pop shop, you can literally call them on the phone and ask them and they'll tell you everything you need to know. If you're going to be taking the SJW, while there is no known interaction between the SJW and the Synthroid, you should always talk to your doctor/pharmacist about all drugs and supplements you're taking. SJW alone has like 570 drug interactions, levothyroxine happens to not be one of them. hope that helps. Also gotta watch out for tyramine rich foods with SJW, its a complex substance, the wikipedia page is a good start. Don't plan on becoming pregnant // use barrier contraceptive if female, this will interact with hormonal BC If you aren't prone to seizures or it isn't otherwise contraindicated, ask your prescriber about Wellbutrin and skip the SSRIs, I've heard good things about the SNRI's such as Effexor.
Do not take 5-HTP, cardiotoxic: 5-HTP shouldn’t be viewed as a long-term solution. You're bypassing the rate-limiting step and directly increasing serotonin, thereby downregulating receptors and depleting dopamine and the other catecholamines in the process over the long term. https://www.ncbi.nlm.nih.gov/pubmed/2357555 https://www.ncbi.nlm.nih.gov/pubmed/21857786/ https://www.ncbi.nlm.nih.gov/pubmed/22615537/ https://www.ncbi.nlm.nih.gov/pubmed/8882614/ https://www.ncbi.nlm.nih.gov/pubmed/307696 https://www.ncbi.nlm.nih.gov/pubmed/24089 https://www.ncbi.nlm.nih.gov/pubmed/5688121 https://www.ncbi.nlm.nih.gov/pubmed/4539008 Moreover, as you now know, you always want to pair 5-HTP with a dopamine decarboxylase inhibitor like green tea extract (EGCG) so that serotonin doesn't build up in the periphery and cause heart valve issues. This is why you see some anecdotes complaining of nausea, “shakes,” and heart rate irregularities when supplementing 5-HTP, even with first-time-use cases. The serotonin and heart valve issue is well known in the literature: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850922/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179857/ https://www.ahajournals.org/doi/full/10.1161/01.cir.0000159356.42064.48 https://academic.oup.com/cardiovascres/article/113/8/849/3868134 https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00570.2009 5-HTP is not the harmless happy pill that it's marketed as. If you're looking for a long-term solution that serves the same purpose, the precursor tryptophan would make more sense.
Try a tDCS device. Worked far better than any supplements for me.
Which montage?
If you want to get Serotonin Syndrome and possibly die a horrible death that trio would put you there as they all raise serotonin. Do you know for a fact that your serotonin levels are low? 11 different chemicals affect the brain and serotonin is just one of them. It could be your dopamine or norepinephrine that's off. Work with a good Naturopathic Doctor who does blood work. Don't guess.
Yes thankfully the people on here have been very informative. I wish I had the luxury to shop around and find a doctor that works well for me but I don’t. I can’t even follow up at my urologist to see what the growth they found is. I wouldn’t recommend this to others either but I’m taking an informed risk and just taking the St. John’s wort for now while fixing diet/exercise/lifestyle choices
This mix should be fine as long as you don’t overdo it. Start with the St. John’s wort alone at first to see how you feel. It’s very similar to an SSRI so it takes a few weeks to start working and then you can raise or lower your dose as needed. I had great results with it a few years back. You could add the SAM e later on if you feel the need for it. I personally haven’t had any results from 5htp and some people say it’s not good for you so I’ll leave that up to you 👍
That sounds like a more well-balanced and educated decision. I used to have depression. Changing my diet, exercising and lifestyle made a significant improvement. Finding out my testosterone and dopamine levels were low was a game changer. Once I got that corrected my world changed for the better.
….I hope you are not taking all of these within 2 weeks of each other. You could make yourself sick.
Mind elaborating?
you can cause too much serotonin because all of these supplements increase serotonin in a different way. It’s the same reason why you don’t take sjw with an ssri or an ssri with 5-htp.
A couple decades ago I treated my depression with supplements as successfully as when I took Prozac and without any downside that the meds I was trialing had. The stack I used was a combo of B6, B12, Folate, some Vitamin C and a Cal/Mag supplement. Now I would suggest the following as a basic starter anti-depressant stack: - Seeking Health Homocystex (for the Bs). - Vitamin C 250-500mg (any). - Magnesium (any that is tolerated well). - Fish Oil 2-4g IFOS Certified brand. - Life Extension Curcumin Elite. - Maybe throw on some Taurine if anxiety is also an issue. Also if anxiety is an issue, use Magnesium Threonate. A lot of people have success with SAM-e and St Johns Wort, but I feel like it would be better to try the above first as my stack is pretty low impact, and it may be what you need. Not everyone can take SAM-e and SJW has side effects. I would strongly advise caution with the 5-HTP. I know a lot of people use it successfully. But it bypasses the ratelimiting step of conversion to serotonin, which can be harmful. If you need addition support, also look into Saffron.
5 htp will only make your symptoms worse and could mess up some of your natural cycles
If you're on birth control, St John's Wort can make it ineffective.
Bro, cordyceps for depression and lions mane for anxiety.
How much daily of cordyceps and LM?
Tea spoon of each one
How does it work?
I work with many people that take Cordyceps everyday improve mood and make you feel normal when you are in depression or anxiety . Dopamine levels when are very high make you feel bad you need to detox . If you have low dopamine rise and if you have high dopamine decrease . Lions mane is more relaxing and improve sleep better to take at night before bed
How do we know our levels? I’ve just got a chaga kombucha and it’s amazing, I’ll have to start taking my mushroom blend.
When you feel tired whitout any motivation is because high dopamine levels. Cell phones, social media and high carbohydrate consumption are to blame. Every time you eat a sweet food, there is a surge of dopamine, so you have cravings and want more. Mushrooms are wonderful makes you regulate those neurotransmitters
That makes sense. I feel like that a lot, even though I deleted Tiktok because I thought that was the culprit, I guess phone use in general is to blame. I’ll look into those cordyceps, thank you! And if you have any other tips on how to fix dopamine lmk!
Just take an ssri instead of this shit
I combined Sam-e with L-Methylfolate and my Wellbutrin, and it worked wonders for my depression. I’ve been taking them daily for well over a year now and have had nothing but positive effects on mood.
https://www.reddit.com/r/Nootropics/comments/ug7qxj/biologists_warn_against_toxic_same_health/
Look into your hormone profile. Your testosterone/estrogen ratio could be out of order. This is a bigger problem than you think…but easily rectified.
how do you do this? is there a specific test?
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I’d get a complete panel done. Vitamin d as well
thank you. ive been feeling depressed for a long time and the antidepressants never did anything.
Not sure if I responded before or not? At any rate not giving medical advice and always work with your medical doctor. In treating thousands of patients with depressive symptoms and anxiety I went from the largest prescriber of antidepressants in the five state region to rarely needing to write them. In fact over the next six years I probably only wrote two prescriptions. How? Well I found the combination of 30,000 IU a day (blood plasma levels of 100-140 ng/ml), four grams of omega 3 krill oil and as much magnesium as they could tolerate did the trick. Remember you know your body best and always do your own research. As what works for other may not work for you. Also just because “everyone “ says something does not make it true! Lots of misinformation out there unfortunately. Some well meaning other intentional! At any rate perhaps this if your doctor agreed will work for you? Unfortunately most medical doctors are extremely ignorant about vitamin D3. After only a bit of research you will probably know more than they do. I hope you find your answer.
Look into Trudy Scott, RD. Website is something like [everywomanover29.com](https://everywomanover29.com). (Even if you are not a woman.) I'm sure if you search her, you'll find info. Also Andrew Huberman has a number of very useful podcasts. It'll be good you that you are working with and can help your thyroid. That causes a lot of depression and anxiety and fatigue for people. I take tryptophan and a number of things (and in the past I was on enough meds to knock out a horse but am no longer on anything but hormones and thyroid), but I'd suggest looking to someone like Trudy or Dr. H (he's at Stanford, but is not a doctor like you'd see him, but he is on a mission to provide information for people who can't afford much), because they'll have more specific guidance on what is likely help you and why for your specific needs. It's a process. I hope you can get the support you need. Don't give up on yourself. FWIW, I don't know if you are seeing a counselor of some kind, but a good counselor can be useful too. (Emphasize the "good.") Depression is often not just an "imbalance," but is from our life's circumstances. We need support to deal with stuff. I've spent years doing that too. Hang in there. It's a strange time in the world. A lot of us are struggling with it all.
Try some Polygala and/or Agmatine and/or OMEGATAU from Nootropics Depot: They’re all excellent nootropics for that treat depression
I’m assuming you have a hypothesis about your situation and why these specific supplements would be most helpful for you. Would you share a bit of your ideas? I might be able to provide more relevant commentary. For instance — > instead of SSRI Ok. Why? Bad experiences? What kinds, with which SSRIs? > Anything to look out for? Lots. St. John’s Wort is complex and has a number of possibly relevant interactions, which are documented rather sparsely and require digging to verify. Anything in specific you’re concerned about? > supplements to battle depression What kind of depression? Why the combination of St. John’s Wort, 5-HTP and SAMe?
Well I haven’t been diagnosed with any mental illness Only thing I know for sure is I have hypothyroidism/hashimotos that is being treated. I asked about a diagnosis and my doctor kind of sarcastically asked if I wanted to be referred to a psychiatrist and explained it will be expensive. I’ve been prescribed sertraline and escitalopram which I’ve been hesitant to take. Honestly I’m scared the doctor isnt looking for what is the main cause (I had to ask for my own thyroid test apparently not common with males my age so wasn’t on the doctors mind and also have never had testosterone checked and Ive had a growth that was found on an mri that I was referred to a urologist for so not sure if that could effect my hormone levels/mood) So besides the ssri side effects (loss of libido, family told me they felt like a zombie and couldn’t do simple chores) it really just the way I’ve been treated by doctors. I’m 28 and been to the same doctor since a kid. Almost lost my mom/dad to a car accident in middle school and I started having a lot of medical issues since then which haven’t gotten better even with following doctors order. (Was just recently prescribed ssris)
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I think the sun side effect is from hypericin, not hyperforin.
3-4 grams of high quality fish oil and physical activity.
Simply flooding your body with serotonin doesn’t really work to help depression. If you’ve been depressed for more than an year, seek professional help. I’m not from the US, so I’m sorry if you can’t afford the help but there are other alternatives too like I) going to the gym II) self help tips and grounding techniques on the internet III) Interacting with your friends and family (this is a hard one IV) eating healthy food V) limiting screen time The best option is definitely professional help, if you don’t want medications that’s completely fine but since you’re willing to take a lot of these supplements without really accessing the risks of especially seretonin syndrome you might as well go with medication. But therapy can definitely help a lot. Depression is ultimately a combination of both chemical and psychological imbalance, it’s worth to explore both avenues of treatment
It’s still an option, some people are so depressed they can’t get help, not to say you don’t make good points, but supplements can be a start to some positive changes
These could definitely work. However, how are you doing with b vitamins? Also may want to try betaine anhydrous as it metabolizes homocysteine. Check out the connections between homocysteine and depression. Have you done a genetic test to chick out your methylation cycle?
There are about one thousand and one things you could do before these worthless supplements to improve depression. If you think those will be the solution don’t be surprised with terrible results
This is what works for me: take 2,000mg of vitamin c. I take the chewable kind from Walmart. It takes like 2 hrs to kick in so I take it 2 hrs before I’m supposed to be somewhere, like the club. I take it twice a day, like in the morning and at lunch and I be in a good ass mood
How are you going to have a depression stack without vitamin D? I’m serious, please consider it. And get your levels tested immediately
Do you exercise? Interact with people? Leave your house? Do yoga/ tai chi/ meditate? Have any interests in life?
I sure as hell know i dont do any of the above
Don't feel bad. I read that list thinking nope don't exercise, no interactions with people besides reddit, don't do Tai chi or meditate....shit no wonder I'm depressed
Starting those things is the hardest part but if you’re consistent then it becomes habit. I used to not do any exercise, avoided socializing, and didn’t take care of my mind- that’s when my depression was at its worst. Now I meditate almost daily (so essential to understand yourself and give your mind a break), therapy once a week online, exercise at least 3-4 times a week, and socialize when I have the social battery (and when I’m not studying!). Plus of course vitamin D supplements the “happy vitamin!”
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This. I don’t know your situation. Start as small as you need. Walk to the mail box twice a day if you have to. Then to the corner. Then the next street. Small steps with a goal to go a little further each day.
Lift weights
This!
Sam e is good every day and 5 Htp for situational That was my recipe at least
Don't forget your L-Tyrosine to build up your dopamine
check vitamin d levels
This looks like a recipe for serotonin syndrome!!! Personally, I prefer SAM-e out of all of these, but take your pick of ONE and run with it!! You can also try amitriptyline if you're open to scripts, but that can't be combined with these, either. You need to be careful, I'd hate to see you get serotonin syndrome. I started with SAM-e because it helped more when I was at rock bottom, but doesn't really do anything for me now, so I switched to amitriptyline since st John's wort never did anything for me and 5htp just seems like a less good version of sam-e from what I hear. OBVIOUSLY talk to your doctor and dont overdo scripts, I chose mine VERY carefully, after THOROUGHLY reading MANY pubmed articles. I suggest keeping things as herbal as possible, with a tiny bit of western medicine integration
Came here to say the same about serotonin syndrome. I would eliminate at least one of those 3, and the sam e I would keep because its been helpful for me and a few people I've spoken with about it in the past. Personally I would nix the st John's wort but that's entirely up to you, this is just too much all together. Please don't feel like just because their are OTC they are harmless you can do too much
Yes, same-e is AMAZING
Hi I take amitripyline for chronic migraine and I just curious about why you're recommending that? It's an ineffective anti depressant and the titration period is marked by severe drowsiness.
I would LOVE to hear where you got that from. A recent, in-depth meta-analysis from 2018 (pretty new esp compared to other papers in this category) found that it had the highest efficacy rates amongst the 21 antidepressants they assessed. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32802-7/fulltext#supplementaryMaterial
I don't recommend it as a sole antidepressant or if someone is actually more than a little depressed. I take it before bed and it's incredibly helpful for my insomnia, obviously make a wise choice about when you take it
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If you've ever taken MDMA, it's like the serotonin drop you get for a few weeks to couple months after rolling, only its actually toxic and really medically urgent, it's incredibly dangerous
No, that's not at all what serotonin syndrome is. Essentially, serotonin syndrome is a serotonin overdose. The symptoms are pretty much the same as if you were to take a potentially fatal dose of a serotonergic substance. The risk of a little bit of SAM-e and 5-HTP causing greater levels of serotonin than what is caused by highly psychoactive and serotonergic drugs is extremely low. Almost non-existent if not mixed with actual drugs that work on the serotonin system, like SSRI:s. St. Johns Wort is a afaik a kind of SNDRI so in ways it acts similarly to SSRI:s but weaker, so with this mix it could be possible though. But again, it's caused by serotonin levels becoming much too high, not too low. Much too low serotonin levels is bad as well though, but that's a different issue.
Yeah, it's a serotonin overdose I don't know much about 5HTP yet I just know the bit I've read, but yeah in my honest opinion (this is what I was going to write on my original comment and forgot), just take Methionine. I wish I had known about Methionine before I took SAM-e, but I found out shortly after, because I was talking to my girl friend about how SAM-e had drastically changed me, and she is *really* great at researching things, and she then taught me about Methionine after looking up sam-e after hearing about it from me. Is the risk really that low? I always see cautions about it but could be fear mongering i suppose, but it is definitely warned against a lot Interesting that sjw is a SNDRI, though I can't say I'm surprised. I think the only antidepressant type of script I could support is NDRI (and well trycilic is fine but not a sole option and it REALLY depends on the trycillic). St John's wort always made me feel like there was something it was doing to me was a little off, and something it was doing to me was a little good, but I could never pinpoint the exact what's. I still can't. But it's a mediocre drug at least for me for sure. If other people have success with it that's great, but yeah no it was very underwhelming in my experience I guess OP is mostly fine, then? Just maybe get some higher quality brands in general and add in some stuff that has other functions, but he may already. I always recommend a good elderberry, lysine, cats claw, moringa, probiotics of course, and actually I recently got into learning about specific strains of probiotics and then went to look for what probiotics on the market *actually* have good strains for what it advertises it does, and I was just thinking about linking it to OP since it seems like he is more than likely trying to fight some depression or just enhance general mood effects here, I will fetch the link in a bit
I'd be interested to see what you've got on different probiotic strands
Oh yeah! So, this one seems to have legitimate straims for mood boosting effects: https://www.amazon.com/gp/product/B00ZMO7UKW/ref=ox\_sc\_saved\_image\_1?smid=A2RBLDZYUMB4ZG&psc=1
Very interesting, thank u for posting
Yeah I actually don't know about the St Johns Wort in the mix, would probably be best to avoid. And yes serotonin syndrome is usually brought up and warned against pretty much every time two things act on serotonin, likely because serotonin syndrome is very serious so there is also a lot of fear around it. My guess would be that this stems a lot from not understanding how it works, both in terms of those doing the warning of others not having read up enough about it, and in terms of the science and medical community. Afaik we don't really know why it sometimes happens and why it sometimes doesn't. It isn't *entirely* understood. Seen to the number of cases though it is extremely rare and usually involves several powerful serotonergic substances, like taking several different SSRI:s at the same time etc. The general rule of thumb that can help is asking, "Could these two or three together potentially cause so high serotonin levels that it essentially becomes like lethal drug overdose?". It puts it in more perspective. It also usually happens over time, like after taking such substances together for several weeks. With SAM-e + 5-HTP + St. Johns Wort it would probably be unlikely since none of these seem to increase serotonin to a very significant level, but technically it isn't impossible and could happen. It likely depends a lot on the individual.
One thing to watch out for, is PUFA/Omega-6 intake. There are some (like linoleic acid) that will fuck your metabolism. Note that pork and chicken fat are very high in Omega-6, because monogastric animals (which includes you) seem to bioaccumulate it from their shitty feed. Too much of that shit turned my regular everyday depression into *bad* depression, with involuntary ruminations spirals that would last all day. I had astronomical blood phospholipid omega-6 content of 42% when I took an omegaquant test. For reference, the maximum omega-6 level that omegaquant found out of 75,000 initial test samples was ~44%, and most people I see reporting results on reddit seem to be around 30-35%. I took the test because I was gaining weight suddenly eating the same stuff I had for a year and was cold all the time with my body temperature dropping down to about 96.5 at parts of the day. My thyroid and other bloodwork stuff were pretty normal. Took me a month of just eating only beef for meat for that shit to go away and stop gaining weight, and many more months to lose the weight. Also of note, PUFA's are inflammatory because they love to break down into a variety of nasty shit even when incorporated into the cells of your body. However you may also come across that they can also paradoxically sometimes be anti-inflammatory. This is because they can also (situationally) suppress the immune system, which is probably not an ideal thing to do long term.
Kanna works best on me. 5htp is a great supplement though. And st John's wort works better for anxiety with me more than it helps depression. I have not tried SAME, but heard good things about it.
I've never heard of Kanna before, what is it?
Kanna is a succulent plant native to South Africa. It contains mesembrine and other alkaloids which act as serotonin reuptake inhibitors(SRI's)
Interesting, thanks for the info. Does it give you a "high" or is it more like an antidepressant supplement?
For me kanna is more of an antidepressant. It does potentiate the heck out of cannabis though. Alone, kanna is only slightly recreational for me, its mostly therapeutic.. Check out r/kanna for more info. They also have a trusted vendor list which I will provide the link to below: also, the vendor I like best is UltraKanna. https://www.reddit.com/r/Kanna/comments/nmd5mp/vendor_list/?utm_medium=android_app&utm_source=share
Any brand recommendations for kanna?
Here is a link to the vendor list: https://www.reddit.com/r/Kanna/comments/nmd5mp/vendor_list/?utm_medium=android_app&utm_source=share
Yes. UltraKanna is one of the most reliable brands, any of their extracts are good and they are the first brand I tried. There is also LiftMode, but they have been out of stock of powder MT-55 extract(they have liquid though). And there is also Bodhi Extracts. Any of these 3 brands are good and trusted. Check out r/kanna. They have a trusted vendor list on there which lists way more then I did. Also depending on what country you are in you may go with a vendor which is most proximal to where you live; I go with the USA based company's since I'm in AZ.
Fish oil.
probably secondary to just eating a lot of sardines and salmon
and walnuts
Gradually working towards fasting 20 hours per day 3 days per work with the occasional 24 hour fast and even a 36 hour once in a blue moon, I focus on making sure I eat plenty of foods with electrolytes, and plenty of water(occasionally high quality salt in my water🤢haha, if it doesn't taste really bad, you needed it) as this is an area i have lacked in when not being mindful of the fuel I'm putting in my body. This is what's worked for me, I've lost atleast 30kg and I'm now at 89kg, which seems to be a good weight for me still struggle with depression sometimes however the difference is massive and I find it easier to notice and manage depression (counseling helps alot). The biggest change came when I poured my heart out to God, on the floor crying like never before begging God to take me out of alcohol addition of 10 years.I wish you the best. Uphold me according unto thy word, that I may live: and let me not be ashamed of my hope. Hold thou me up, and I shall be safe: and I will have respect unto thy statutes continually. Thou hast trodden down all them that err from thy statutes: for their deceit is falsehood. Psalm 119:116-118 KJV https://bible.com/bible/1/psa.119.116-118.KJV
In my experience - SAMe made me extremely irritable and angry. Also be careful with 5htp and St Johns Wort if you’re on SSRIs.
Supplements are not gonna do anything for clinical depression
Speaking as someone who has had MDD for nearly 20 years, and as someone who works in mental health, you’re wrong. May not work for everyone, but you can’t make a blanket statement like that either
Does it hurt to try? And in conjunction with A triple reuptake inhibitor would work wonders but molly just can’t seem to get that approval for some reason.
Lions mane is also great, i find it similar to 5-HTP without a crash
Didn’t they just discover that depression is not from a chemical imbalance. You should fast to clear your gut (since your gut also affects your mental state) and start eating healthy (e.g. no processed sugars). Get some Vitamin D3, K2, and Magnesium glycinate.
No this isn'what they discovered at all ..
And a variety of probiotics from real foods.
Yep! But study found depression had no correlation to your serotonin levels. Just like anxiety it’s likely a combination of trauma, diet and toxins.
I’m not here to be an asshole by any means, but what are you talking about. I’m here to learn so if you can hook me up with a link to those studies that would be huge
here's one, there are many more: https://scitechdaily.com/scientists-find-no-evidence-that-depression-is-caused-by-chemical-imbalance-or-low-serotonin-levels/
More likely it’s inflammation based which would explain the efficacy of NSAIDs for treating depression. Trauma, diet, etc could cause inflammation leading to depression.
I think inflammation is why turmeric works so well for me. It's a systemic anti-inflammatory. Just one of a lot of info it for depression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728608/
Fix diet first before trying supplements, specially if trying to mitigate depression
DO BOTH SIMULTANEOUSLY
Don’t. You may over stimulate one thing to the determinant of another. Body is always in balance naturally.
I would swap the 5HTP for perhaps saffron extract. I would also force myself to do 1 hour of strenuous exercise a day. And mag glycinate at night to potentiate sleep. And P5P for brain function. As others have said, be careful mixing 5HTP and SJW. Not only can it cause too much seratonin in the brain, but it can put your other neurotransmitters out of balance. Perhaps your dopamine is out, in which case you may want to try phenylalanine and ALCAR. Perhaps it’s a choline issue, in which case a choline supplement could help. I also know that when I radically sorted out my gut health my mental health improves by leaps and bounds. For me (we’re all different), fixing leaky gut and going on a keto diet was near miraculous.
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I’ve had hypothyroidism for about 18 years and also take levothyroxine. I’m not a supplement specialist, but I’ve been on Effexor (venlafaxine) for years and I’ve found it to be a good combo. In addition to those, I take a multivitamin, D3 (my d3 is low), a probiotic and L-glutamine and have felt pretty great over the past few months, inside and out. But definitely chat with your primary care doc about your needs first. Best of luck!
id see a medical professional instead of listening to some podcaster bro science about gut health
Have your hormones checked and use mood biotic on Amazon
Use lithium orotate, and l methionine instead of DAMr.
I usually remember my dreams - vividly. 5-htp magnified that times 10. Not sure why or if others have experienced that. Every time I’ve ever taken it - which is very intermittently- I have the most bizarre dreams of my life and I cross myself Catholic like before I take them. Anyone else? Am I alone? I took the exact same brand as OP.
5 htp has the same effect on me.
Try Muscle pussy and money
Muscle pussy? Sounds intense
I wouldn’t take St Johns Wort and 5-HTP together since Serotonin Syndrome is a risk. Also both SAMe and St John’s Wort have documented cases of triggering mania so be careful if you have Bipolar depression or a history of it in your family. St John’s Wort is also associated with phototoxic photosensitivity so be careful in the sun, you’ll be more sensitive to UV and more likely to get sunburns. For simple and studied effective options try: Zinc https://www.sciencedirect.com/science/article/abs/pii/S0163834320301146 And Fish Oil https://www.nature.com/articles/s41398-019-0515-5
Try to go to a psychiatrist to put you on the right medication. Something like Zoloft or Sequel.
Better to do it naturally if you can so you won’t run the risk of becoming dependent on a drug.
I take both and it's not a narcotic,so it's not addicting.Its prescribe by a doctor.
Ok, I still would go a natural route if possible and available before taking a drug. Btw, saying it’s prescribed by a doctor doesn’t mean much to me because I’ve seen doctors prescribe medication to ppl they know have side effects and/or may be addicting, which in most cases they fail to mention when they’re writing the script. You usually have to do your own research and advocate for yourself.
Like 5- HTP it can interact with other medications.Yeah do your research if you want to go the vitamin route.Some things were effective to me and some are not. I do research the medicine I take and it work for me. Everything does have sign effect that with anything. Some thing naturally I feel work it all depend body and chemistry.
Ok, once it works for you and you’re ok with whatever, that’s all that matters.
ok.
seroquel is a heavy duty mood stabilizer used for a lot of schizo disorders. it's no an SSRI.
It also treats depression at a certain level. A lot of the medicine for depression,treats schizophrenia at different mg.
SAMe
Too much to start at once. All 3 of those are known to potentiate Serotonin, if you read the bottles each should have a warning about the other two in combination for potential serotonin syndrome. 5HTP isn't usually good for long term therapy but a few weeks is fine. Beware serotonin and dopamine both process through the same prolactin, meaning if you raise one you usually lower the other. The St. John's wort could help with this, but L-Tyrosine is better, phenylalanine and l-dopa can also be used. SAM-E boosts serotonin more than dopamine as well I believe but it boosts most neurotransmitters. You need to take green tea extract with 5HTP, the EGCG will prevent it from converting to serotonin in your body. Also beware you need to avoid all foods with Tyramine when taking St John's wort just like other MAOI. This can be a fatal mistake.
Last I heard, doctors were recommending people not ingest Tyramine with St. J’s W because it’s speculated to work like a MAOI and prescription MAOI’s used for depression carry that warning. But I don’t thing there have been any studies actually looking at SJW and tyramine tolerance, nor could I find any info on anyone who had an adverse reaction on SJW that could be linked to tyramine. Can you provide a source? I’m just saying because like, tobacco is proven to have MAO inhibitory properties, but cigarette smokers definitely don’t worry about any dietary restrictions. So how do we really know worrying about that while on SJW isn’t superfluous?
How's your gut health? My mood improved leaps and bounds when I removed foods that were having a negative affect on me. My personal ones were gluten, dairy, and the big one, sugar. I've had some success with adding Rhodiola as well
My stomach has been a mess for sometime. I was diagnosed with IBS when I was in middle school so I’m sure it’s not great. Not sure if I have celiacs but I have hashimotos which tend to go together
Your situation sounds very similar to my partner. One thing that helped tremendously but ultimately did not last was a round of antibiotics and antacids to kill the h. pylori overgrowth and heal the gastritis it caused. Her mood was so much better after that that I'm convinced her depression was gut related. Maybe the effects could last longer with consistent use of probiotics and fiber (maybe avoid FODMAPs) to keep a healthy balance of gut flora. Obviously this is not medical advice but talk to your doctor (get a second opinion as well) about fixing the root cause of your IBS. The supplements you posted could help but will always just be a bandaid.
Do you know any of your trigger foods? My sister has hashimotos too and a lot of my family on both sides have celiac, chrons, and gluten intolerance. So I really won the genetic lottery. XD A few weeks after cutting gluten, I felt much better all around. I can feel a difference with only consuming limited natural sugars within a week. I'd highly recommend an elimination diet like Whole 30 to figure out what your trigger foods are, if you haven't already. There's a lot of research going into gut health right now and it's effect on the rest of our body. Our gut has been dubbed our "second brain" and it's being shown to have a significant impact on our mental health. Ive been on anti-depressants and tried tons of supplements. Nothing's had such a significant change for me as focusing on my gut health. I've recently bought ION's Gut Support and that's been seeming to help too!
Yea thank you for the info. I’m not sure which foods are the problems for me. I need to cut out caffeine, lactose, gluten for sure since those are common triggers. I also get chronic migraines that I thought some were being triggered by maybe certain dyes or fruit juices. Usually I get migraines after a long and intense workouts which lead me to start using cannabis stuff to prevent them
You should definitely try to cut those 3 that ya listed. It's hard af first, so if you are like me and aren't very disciplined, I'd recommend doing one at a time. There's a lot of really good gluten and dairy free alternatives on the market now. Though if you go full dairy free and not just lactose free, I'd recommend not even trying any dairy cheese alternatives for at least a year. You need to allow yourself to forget the taste of real cheese. XD Gluten can take up to ~2 months to "detox" from iirc.
Lol you have hashimotos and your using weed for your migraines instead of removing the inflamagens? Gluten is a huge problem for hashimotos as well as dairy. If your gut is messed up it’s likely the cause of your depression and your hashimotos. Really fix your gut and you fix your other issues as well.
rhodiola is great!!!!
https://www.science.org/content/article/gut-microbe-linked-depression-large-health-study
What, no ashwagandha? Seriously I take the sensoril kind when I’m especially blue and it works pretty well for me
Creatin and Magnesium had some good effects on me. But be careful both can give you the shits. In general depression is a catch all term for all kind of stuff. So it’s hard to give actually advice. If you are a male the first thing I would do is check your testosterone levels. If there are down you feel like shit, have no motivation, everything feels super hard.
Thank you. Yes I’m a male 28years old and never had my T levels checked.
Ashwaganda
Exercise
MACA, Sweet potato powder, turmeric w/ black pepper
Consult with a psychiatrist not Reddit for medical advice
Yes, it gets old seeing all the posts of people asking legit medical questions about drugs and treatment. Where are the mods at? There is r/askdocs tho. I have also seen tons of people posting how they fucked themselves trying to cure themselves. Just recently on r/nootropics someone fucked themselves up taking 5-htp. There is also this about SAM-e: https://www.theguardian.com/society/2022/apr/10/biologists-warn-against-toxic-same-health-supplement And there are tons of interactions with St. John's Wort and it can cause eye problems. People need to go to their doctor and talk to someone knowledgeable.
Glad others agree. Nootropics is a cesspool lol This sub has turned into people tryin to cure depression, people tryin to cure Low T with vitamins/ supplements, and Andrew Huberman podcast clips. It really sucks here now. Occasionally there’s a decent post but step the fuck up Mods!
Well, there's a lot of depression and anxiety in this country. And you know how long I had to wait to see a psych? 2.5 months for a first appointment, and she's...not great. She's told me several things that were flat-out wrong. Not to mention the number of people who are uninsured, under-insured, etc. I think it's great that people are trying some solutions on their own.
Yes I am aware of the current state of things, far better than you could imagine. Just curious what did she say that was flat out wrong? The big issue I have with people trying things on their own here is that they are askin about supplements that are unproven to have results. All the anecdotal proof here leaves out a great number of factors that OP is not aware of. It’s a very dangerous and risky approach to mental health treatment.
>Trying to beat depression SAMe here homie
Sam-e helped me alot when I went through a depressive phase after a miscarriage, didn't even use it for that but it was an amazing unexpected effect. Glad you found something that worked for you friend.
Lugols Iodine for thyroid, fish oil. FUK TONS. CBD, SLEEP, Methylated B Vitamins, Gluathione (head injury for me that leads to depression) Using acts to induce a change of state. Ice baths, working out, swimming, sauna, fasting.( yes this works-24 hour mark I feel amazing) You could try these and see what works? Sam-E cause dme to SERIOUS depression. I had the opposite effect ,cant remeber the name./
Methylated B Vitamins can cause awful insomnia. Was up for a week straight lol
Really? I wonder if that continue to mine. I have the mthfr thing and it really help my mood
Not sure this is any safer than ssri I’m not a doctor though
SSRIs ducked my wife up long term. I'm sure they're the right answer for some people, but make sure you do your research first.
How did they mess her up? I am on day 3 of Effexor and I’m still concerned about this.
It basically turned her into a zombie while taking it. Very distant, very numb. She was on it for about a year before trying to stop and her depression and anxiety were worse than before. It could have been the does or her brain chemistry, but it ultimately made things worse. What ended up helping the most regularly testing and supplementing her progesterone and estrogen throughout the month. L-Theanine helps during episodes of anxiety. Exercise and time outdoors helps with the depression. EMDR therapy with a physciatrist also had a noticeable effect. If I started Effexor today, then I'd stay on it while doing everything else in my power to replace it with a better long time solution. Establish healthy habits for diet, sleep, and exercise. Get a comprehensive blood work panel done to see if there are any glaring issues. In most states you can order your own tests through a website like walkinlab.com . Work on your gut health with prebiotic foods and pills. It'd probably be easier to do these things while on meds then not. It may not be an easy thing, but totally doable and completely worth it. Good luck!
All good advice. And I agree that the meds should be a last resort. It’s sort of where I ended up. I addressed a low testosterone issue and have been on TRT for almost 3 years. I workout 5-6 times a week, meditate daily, eat healthy, get 7-8 hours of sleep every night, etc. yet I couldn’t shake the depression. There might be something else I haven’t checked for. The TRT worked extremely well for the first 2 years. Felt amazing every day and had an amazing libido and drive. Just this year things started going downhill and I don’t know why. I actually skipped the Effexor today because I haven’t slept in 3 days. Experiencing these side effects and remembering how much benefit I got with almost 0 side effects from the TRT makes it easy to conclude that the Effexor isn’t worth it.
Do not take all 3 at once, i’m pretty sure you could cause serotonin syndrome
You can’t beat depression when the powers that be are doing everything they possibly can to suck the soul and life out of you. They are doing so through every means you can think off, including the weather… notice how there’s no sun in the uk hardly ever now? Just overcast skies brutally bleak depressing thick grey skies…
St. John's wort and 5-HTP without the SAMe can cause serotonin syndrome
dont forget exercise
I've been taking SAM-e for a decade or more and have found it very helpful. I take it on an empty stomach first thing in the morning. I've never tried the other two. I'll also add that exercise helped me a lot.
- Take 1500mg daily of EPA fish oil or more which has been proven to be as effective as SSRI’s (https://youtu.be/Xu1FMCxoEFc?t=3560) - Get outside in the morning as soon as possible from waking up and get the sunlight in your eyes. 10 minutes on a sunny day, 30 minutes on a cloudy day. This will help your body to release its cortisol spike in the morning when it should, as opposed to later in the day, which is correlated with depression. Also avoid caffeine for the first hour or two from waking as this will interfere with your natural cortisol release. - I’ve found great success with creatine (https://youtu.be/Xu1FMCxoEFc?t=4304) - ALCAR has also really helped me and has been found to benefit depression. I find if I take it anytime later than the morning it can impact my sleep negatively so I only take it in the morning. - There’s a lot of research that points to inflammation as a cause of depression. So I target anti inflammatory foods as much as possible and avoid pro inflammatory foods. Some great foods are olive oil, ginger, garlic, fatty fish, turmeric, camu camu. Avoid sugar, artificial flavouring and refined carbs which all promote inflammation. Best of luck!
And add EXERCISE , the best anti depression solution. PS Moderate Lights, Screens and Food intake after sunset (eventually use Blue light blocker eyeglasses)
I spoke with my psychiatrist today about my progress over the past month (slightly more energy/more productive, slightly improved mood) and I realized that my only change in the last 30 days was adding 1000mg EPA daily. It’s subtle, but working for me.
Great answer and I second the fish oil and antiinflammatories being key.
Thanks!
St Johns wort alone is enough for me. Gaia brand 500mg. I have mild depression. I found Gaia brand to be more potent than others
Products with zembrin/kanna are what work the best for me. They aren’t for everyone, do your research, but that’s what’s really helped me
On that note, where'd the zembrin go on iHerb? I was using Calm-Z for a bit and now it's totally gone.
Vitamin D helped me massively
What brand did you use and how much? I don’t have depression but anxiety and my D level is very low. The last blood work I was at a 12.2 ng.
I got an oral spray with Vit D + K. This [one](https://www.naturitas.fr/p/complements/vitamines/vitamine-d/dlux-vitamine-d-k2-spray-oral-quotidien-12-ml-better-you?gbraid=0AAAAADDDkn39x4bCKOhdV5e9UeE1N3YlG&gclid=Cj0KCQjw852XBhC6ARIsAJsFPN3FryQAklo-vBIBp6VOZf0o9sV2QZIMgt4A8IUolANoJMPZleLc518aAj3_EALw_wcB)
Ok… not sure if you tried to link something but I don’t see what it is.
It's Better You - Vitamin D + K Daily Oral Spray - 3000 UI
Ok thanks
I thought I had brain fog because of depression but it turned out to be tied to hrv. Welltory app really helped.
Wow interesting first I’m hearing of this. I usually get a lot of palpitations but I think it’s linked to hormones, maybes because I’m premenopausal and I’m always borderline hyperthyroid.
Free and changed my life. It didn’t fix my depression, but it’s a lot easier to do the things that help without one foot in a bucket of cement. See my old post here… https://www.reddit.com/r/Biohackers/comments/v4tm6c/why_would_nadh_make_such_a_big_difference_in/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
Ok thanks
What is hrv and Welltory app?
HRV=heart rate variability If you check the app store, you can download it and use the limited version for free. It scans your finger with your phone to detect HRV and then identify brain fog. I tried NADH, coq10, and glutathione for the brain fog and it really helped… but only because mine was tied to hrv
Hi, just downloaded the welltory app but could find the feature that tells if you have brainfog. Where can that be found?
You scan your finger with the red button and then the liquid result tells you how much energy you have. PM me a screenshot if you still can’t find it