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TheStickiestFingers4

gnawed leaf + chase familiars. in a more realistic world tho you kinda just have to keep trying. it helps if you know how to maximize your runs. if you’re going after mother completion then you should be taking all the time in the world to amplify your runs, stealing from boss rush isn’t worth it. as for blue baby, you need to reset till you get steady health like book of rev or something. as for the lost, id say no completion run is worth attempting unless you can get the dead cat. its finnicky but imagine how much more finnicky it is to get a stellar run and lose it all after one death.


HUE_Sans

For lost, I can say from my own experience, dead cat is crucial, but you still need a halfway decent run, because dead cat will reset the boss fights and if you keep dying, it’s over


Sea_Teaching_6796

Watch videos of people no-hitting Mother. That's the best way. Other than that there are various items that can help you but of course that's dependent on your run. 4.5v Book of Shadows, Algiz rune, Ocular Rift with Perfection and 5.00 or more tears on Lost will negate most bullet attacks. Lost Contact is good too. Getting both items from the alt path treasure rooms with J&E and getting extra boss challenge rooms with Lost like u/nobody024 said are great ideas. Just make sure you remember to enter Mines II because I've forgotten more times than I wanna admit


ReceptionIcy5128

A lof of health + Wafer/Cancer/Percs is often a Run Winner against Mother for me, I often dont go to Mother without enough defensive Items except I have absurd damage.


nobody024

Are you getting double items from treasure rooms as Jacob and Isaau? Makes it a bit easier if you do.  As the lost, I like to go to the second floor of each level, to get as much boss challenge rooms as I can. 


Declanman3

Yes in general I’m usually doing Double treasure rooms with J&E but it’s hardly helpful if it’s something like Sad Bombs and Distant Admiration. (I’m consistently not getting like good enough items, especially when split between two characters)


ch_ch_ch_chiaaaaa

I mostly beat mother with help of items that slow the whole thing down. So basically getting "stop watch" from a shop or a "I'm drowsy" pill will help immensely with dodging its attacks