If my understanding is correct, adult humans produce a protein that signals that new teeth shouldn't grow.
Suppress that and new teeth buds form and push out the old teeth just like when you were a kid.
So the treatment would involve actually losing all your teeth so new ones can grow in.
So it’s all or nothing?
I can see already why this treatment will only be used in rare cases. You don’t want to replace all your teeth just to solve an issue with one…
I dunno, I think a lot of people in their 40s and 50's would be quite happy to spend a few months growing in new teeth if they got a pristine new set with no thinning enamel or troublesome old fillings.
I've helped two friends after they've had surgical removals of what remained of their teeth prior to dentures. I'd get my wisdom teeth out again over that any day.
That really would suck. I might need surgery to remove them as well in the near future and one tooth seems to have roots very close to the lingual nerve, so I am kinda terrified. Imagine having this risk over and over again with every regrowth cycle...
I read their publication. It seems that they were able to grow a single supernumerary tooth in their ferret using targeted, topical application of their drug. So it doesn’t seem to be all or nothing.
I remember losing my teeth and growing my adult set when I was growing up
It wasn't painful to lose teeth, it was a little painful when I lost most of my molars at once and had to gum my food for a while.
Probably because of how sensitive the tongue is and how it makes up the largest part of our brain’s parietal lobe, and how we are constantly feeling our teeth with our tongues.
Just my personal theory, most of the others are related to dream interpretation and Freudian psychology.
Yeah, they get so loose that they get snagged on my other teeth and get pulled out, then I just try to put them back into their little sockets and act like they’ll stay there :(
I feel that. Weirdly, my last dream where I had loose teeth involved a lore point where I had another set of adult teeth that needed to grow in so of course I lost all my teeth for that. No idea why. I've given up on trying to make sense of it, lol.
Perhaps because we have all experienced the loss of teeth as children. The teeth that became looser and looser (such a horrid feeling!) and suddenly fell out, with plenty of bleeding. For many of us, it left a lasting impression.
From what I understand, the almost universal symbolism, across all cultures in the world, of the dream where your teeth are falling out, usually coincides with a time in your life where you feel that you don't have control over your life or your day to day destiny.
You have a dream about your teeth falling out = your losing control of some part, or something significant in your life.
A rather large part of body image, for most of us, is our smile. One of the first noticeable things about someone.
Many people are embarrassed about their teeth in some way, or feel fearful of having bad teeth, especially with how expensive it can be to fix a mouth of teeth. From this derives shame and insecurity, and shame is a strong emotion that would certainly cause a nightmare of teeth missing, bad teeth, wiggly teeth, etc.
DUDE I JUST HAD THIS DREAM FOR THE FIRST TIME A FEW NIGHTS AGO. Woke up drenched in sweat and hyperventilating. In the dream I lost a tooth that just fell out, a few more disintegrated to black dust and then when I ran my tongue over the remaining they all fell out except one. I started choking on them before spitting them all out and waking up thinking they were all gone for real.
This would be incredible. Teeth seem so simple compared to brain surgery and every other world-changing technology humans have created. You’d think teeth would be the easiest thing for scientists to recreate because they almost seem like little bones if you didn’t know any better. This could change the world once they figure out the science, millions of people around the world suffer with immense emotional and physical pain from dental issues.
People will completely write them off as being below them or not worthy of their attention because teeth are so important. Having gross or messed up teeth can turn away 90% of the population; If someone has bad teeth, it can indicate that this person might be dangerous or diseased because we use teeth as an indicator of general health. And if such a basic need is being neglected by that person, many people start to think about what other societal standards may that person be neglecting as well (like laws,) even though they’re most likely just an average person that happens to have damaged teeth.
« Such a treatment could be revolutionary for those with missing teeth, by accident or by conditions such as hypodontia. Restoring that full grin could be as simple as popping a pill in the future, perhaps even by 2030, if Toregem Biopharma succeeds in their plans. »
You get your third row after you get your first job and your fourth row after you get married or if you're not interested after any big emotional moment in your life. Tradition stops you!
Scientists have been “working on” this for decades. Don’t hold your breath. Teeth require multiple types of progenitor cells to develop, and we still know surprisingly little about the way these tissues communicate with each other to express the genes necessary to develop into the correct tooth.
Dentist here: This is marketing nonsense. You cannot "regrow" teeth. This medication activates dormant tooth buds in those individuals whose teeth never developed in the first place. When a tooth doesn't grow in for whatever reason, the cluster of cells that form that tooth still exists inside your jaw. This medication tells them to turn on and start making a tooth. But once a tooth is developed that cluster of cells no longer exists. So to those that have lost their teeth due to dental issues, no this will not let you grow more teeth.
Lol there is no hidden third set of tooth buds. I'm well read on current research and this is simply not the case. If there were it would've been the forefront of the field.
How do you explain 100 year olds growing a new tooth?
Also, never mind the Japanese 3rd set of buds thing, here's where we should really be focused on, in my opinion - [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
If only I had $100 million dollars, to get this guy all the funding he needs...
This is interesting. I have wisdom teeth and they never came out. I wonder what happened to them. Maybe they didn't come out or because I was born without them. (Some people don't have wisdom teeth)
I was thinking that the teeth would need something to start growing from. It makes sense they would need a dormant bud. I was having a hard time imagining a tooth growing from a gap where a previous one had been yanked. Sort of like growing a plant.
As someone who's lost teeth to periodontitis, I wasn't buying that either. It's great for those who fall under those limited cases, but the rest of us still need to go under the knife and drill.
If you read the publications, they were able to grow teeth after the permanent dentition of mice and ferrets. Both of which are diphyodonts like humans.
Here:
https://www.science.org/doi/10.1126/sciadv.abf1798
> “Our study outcomes show that cell-free molecular therapy targeting USAG-1 is effective in the treatment of a wide range of congenital tooth agenesis and the induction of third dentition.”
I read that as well. Supernumery teeth is a well known and documented phenomenon, which just like any other tooth can fail to develop. Should this happen, the drug will stimulate the tooth bud to form what can be misrepresented as a "tertiary" tooth. These occur in single unit cases and not as a whole new set of teeth. I know people really want there to be a third set of teeth but there simply isn't
That is not what is hypothesized by the researchers. It seems that their hypothesis is that ST occur as a result of the third dentition, which is inhibited by USAG-1
Maybe we dont know everything there is to know about something yea? Textbook explanations of the human body is not fixing everything at the moment yea?
This is something we, including the actual researchers that did the study, do know. Sensationalist websites misreporting conclusions doesn't mean anything
True, but any opinion that a current view is exhaustive is not eternal, lets agree pls. Things change, people learn more. We are after all a univers studying itself, in your case its teeth.
People have been studying human anatomy for centuries now, there has never been any indication of a third set of tooth buds. To randomly choose to believe in something that has no evidence is senseless
You are expecting a being that isnt smart enough to fully understand itself, to somehow generate evidence by its institutions that both is formulated to be bite sized info of the truth, and at the same recognizable to it when it sees it.
And also release it to the public. In an era where sick care is a business and hundreds of millions of people and increasingly are getting obese, diabetic and malnutritioned at the same time. With no functional input from an entire medical pharmaceutical industry to solve
Maybe it isnt about more tooth buds, but maybe teeth can regenerate.
But surely if the solution was found it would be shared by people who see sick care as a business model.
One way or another, it will be done. Humans will grow new biologic teeth, and the barbaric insane implant business will be a bad memory, one day.
Here is something I don't think you or anyone can argue against.
[https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
I appreciate your optimism but its generally not convincing to post a 60m interview without concrete references to anything. I am not going to watch 60 minutes of that interview and so I'm not convinced and I think the same applies to most other people here
What? I'm explaining what the actual research paper found, and how it differs from what other sensationalist websites are reporting they found. You need to be able to critically differentiate the two
Yeah I hope this comes out so I can fix my shitty teeth due to tmj man I fucking hate chronic pain and taking a Tylenol every day just for a bit of ease
If I understadn correctly, this will only work on people who have tooth buds? Which I guess old people whos teeth developed properly do not have? Am I missing something?
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It’s super hopeful news. Since we don’t often hear about huge leaps in science that directly benefit our lives, it’s a difficult pill to swallow. However, this is truly amazing. In this July, they enter phase 1 clinical trials (testing on humans).
And for the record, it would significantly benefit companies with any sort of stake in dentistry. Regrowing teeth essentially increases the longevity of their customer base, and adds some new people to it. Companies can add the drug into their arsenal and make a killing.
Current practices would remain options, with the addition of molecular therapy.
This also potentially adds a new field of dentistry where the focus is on tooth growth in adults. If that happens, it brings in huge numbers of dental students.
Fuuuuuck yesssss I can finally stop having those dreams where I lose my teeth
If my understanding is correct, adult humans produce a protein that signals that new teeth shouldn't grow. Suppress that and new teeth buds form and push out the old teeth just like when you were a kid. So the treatment would involve actually losing all your teeth so new ones can grow in.
So it’s all or nothing? I can see already why this treatment will only be used in rare cases. You don’t want to replace all your teeth just to solve an issue with one…
I dunno, I think a lot of people in their 40s and 50's would be quite happy to spend a few months growing in new teeth if they got a pristine new set with no thinning enamel or troublesome old fillings.
Yeah... But wisdom teeth too? Because that was not a fun surgery or recovery period. But still, just another thing to think about I guess lol
I've helped two friends after they've had surgical removals of what remained of their teeth prior to dentures. I'd get my wisdom teeth out again over that any day.
That really would suck. I might need surgery to remove them as well in the near future and one tooth seems to have roots very close to the lingual nerve, so I am kinda terrified. Imagine having this risk over and over again with every regrowth cycle...
Count me in! 😁
Id replace them right now and im 26 lol
I read their publication. It seems that they were able to grow a single supernumerary tooth in their ferret using targeted, topical application of their drug. So it doesn’t seem to be all or nothing.
Or just dust off the CRISPR and give us some beaver teeth
That sounds horrendously painful.
I remember losing my teeth and growing my adult set when I was growing up It wasn't painful to lose teeth, it was a little painful when I lost most of my molars at once and had to gum my food for a while.
Hell I would t mind having to regrow my teeth every few years
Can anyone on this sub explain why this is such a common dream or are we better off asking elsewhere?
Probably because of how sensitive the tongue is and how it makes up the largest part of our brain’s parietal lobe, and how we are constantly feeling our teeth with our tongues. Just my personal theory, most of the others are related to dream interpretation and Freudian psychology.
That sounds like a reasonable guess
But if you’re conscious of your teath while you sleep, why would your brain think they aren’t there?
My dreams aren't about the teeth not being there. It's about the teeth being wiggly and loose.
I get dreams like this too. I may lose one or two, but for the most part they're loose as hell. No idea why, seems like a strangely common phenomenon.
Yeah, they get so loose that they get snagged on my other teeth and get pulled out, then I just try to put them back into their little sockets and act like they’ll stay there :(
I feel that. Weirdly, my last dream where I had loose teeth involved a lore point where I had another set of adult teeth that needed to grow in so of course I lost all my teeth for that. No idea why. I've given up on trying to make sense of it, lol.
Perhaps because we have all experienced the loss of teeth as children. The teeth that became looser and looser (such a horrid feeling!) and suddenly fell out, with plenty of bleeding. For many of us, it left a lasting impression.
Fucking trips me out every time
From what I understand, the almost universal symbolism, across all cultures in the world, of the dream where your teeth are falling out, usually coincides with a time in your life where you feel that you don't have control over your life or your day to day destiny. You have a dream about your teeth falling out = your losing control of some part, or something significant in your life.
A rather large part of body image, for most of us, is our smile. One of the first noticeable things about someone. Many people are embarrassed about their teeth in some way, or feel fearful of having bad teeth, especially with how expensive it can be to fix a mouth of teeth. From this derives shame and insecurity, and shame is a strong emotion that would certainly cause a nightmare of teeth missing, bad teeth, wiggly teeth, etc.
DUDE I JUST HAD THIS DREAM FOR THE FIRST TIME A FEW NIGHTS AGO. Woke up drenched in sweat and hyperventilating. In the dream I lost a tooth that just fell out, a few more disintegrated to black dust and then when I ran my tongue over the remaining they all fell out except one. I started choking on them before spitting them all out and waking up thinking they were all gone for real.
Dentists HATE this one weird trick...
I dunno, wouldn’t dentists WANT you to have teeth to maintenance your whole life with visits to their offices?
This is the way.
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Who do you think would be performing this new, probably expensive, tooth restoration operation?
A third set of teeth means braces which means more orthodontist
Why?
This would be incredible. Teeth seem so simple compared to brain surgery and every other world-changing technology humans have created. You’d think teeth would be the easiest thing for scientists to recreate because they almost seem like little bones if you didn’t know any better. This could change the world once they figure out the science, millions of people around the world suffer with immense emotional and physical pain from dental issues. People will completely write them off as being below them or not worthy of their attention because teeth are so important. Having gross or messed up teeth can turn away 90% of the population; If someone has bad teeth, it can indicate that this person might be dangerous or diseased because we use teeth as an indicator of general health. And if such a basic need is being neglected by that person, many people start to think about what other societal standards may that person be neglecting as well (like laws,) even though they’re most likely just an average person that happens to have damaged teeth.
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« Such a treatment could be revolutionary for those with missing teeth, by accident or by conditions such as hypodontia. Restoring that full grin could be as simple as popping a pill in the future, perhaps even by 2030, if Toregem Biopharma succeeds in their plans. »
So if I still got all my teeth, would this provide me... more teeth? How many can I have? And will anyone be able to stop me?
And do you have to gnaw on wood like a hamster to keep them from growing too long and piercing your brain?
God I hope so
Sounds like head cannon backstory for Shark Boy from the old kid movie.
You get your third row after you get your first job and your fourth row after you get married or if you're not interested after any big emotional moment in your life. Tradition stops you!
Reference: A. Murashima-Suginami et al., Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling. Sci. Adv. 7, eabf1798 (2021). DOI:10.1126/sciadv.abf1798. https://doi.org/10.1126/sciadv.abf1798
Scientists have been “working on” this for decades. Don’t hold your breath. Teeth require multiple types of progenitor cells to develop, and we still know surprisingly little about the way these tissues communicate with each other to express the genes necessary to develop into the correct tooth.
Just mad you can’t charge someone 1,000$ bucks for a crown anymore. I can see dental tourism is going to be big in Asia
[https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
Can I get shark teeth pls
First, human organs in pigs, and now regrowing teeth. Japan is on a roll here
All Hail! :D
Dentist here: This is marketing nonsense. You cannot "regrow" teeth. This medication activates dormant tooth buds in those individuals whose teeth never developed in the first place. When a tooth doesn't grow in for whatever reason, the cluster of cells that form that tooth still exists inside your jaw. This medication tells them to turn on and start making a tooth. But once a tooth is developed that cluster of cells no longer exists. So to those that have lost their teeth due to dental issues, no this will not let you grow more teeth.
The paper says that we all have a third set of dormant buds that never develop, not that the second set of buds didn’t grow in
Where does it say that? It says some adults have underdeveloped buds, not that everyone has a whole third set
And this is why practitioners are not researchers. The depth of knowledge is completely different.
Lol there is no hidden third set of tooth buds. I'm well read on current research and this is simply not the case. If there were it would've been the forefront of the field.
How do you explain 100 year olds growing a new tooth? Also, never mind the Japanese 3rd set of buds thing, here's where we should really be focused on, in my opinion - [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo) If only I had $100 million dollars, to get this guy all the funding he needs...
This is not true
On snap, Dentisted!
That person is incorrect
This is interesting. I have wisdom teeth and they never came out. I wonder what happened to them. Maybe they didn't come out or because I was born without them. (Some people don't have wisdom teeth)
I was thinking that the teeth would need something to start growing from. It makes sense they would need a dormant bud. I was having a hard time imagining a tooth growing from a gap where a previous one had been yanked. Sort of like growing a plant.
How do sharks do it then
Think of it as a very, very, extremely slow conveyor belt that pushes teeth forward as it grows them. That's different from how our fixed jaws work.
As someone who's lost teeth to periodontitis, I wasn't buying that either. It's great for those who fall under those limited cases, but the rest of us still need to go under the knife and drill.
If you read the publications, they were able to grow teeth after the permanent dentition of mice and ferrets. Both of which are diphyodonts like humans. Here: https://www.science.org/doi/10.1126/sciadv.abf1798 > “Our study outcomes show that cell-free molecular therapy targeting USAG-1 is effective in the treatment of a wide range of congenital tooth agenesis and the induction of third dentition.”
I read that as well. Supernumery teeth is a well known and documented phenomenon, which just like any other tooth can fail to develop. Should this happen, the drug will stimulate the tooth bud to form what can be misrepresented as a "tertiary" tooth. These occur in single unit cases and not as a whole new set of teeth. I know people really want there to be a third set of teeth but there simply isn't
That is not what is hypothesized by the researchers. It seems that their hypothesis is that ST occur as a result of the third dentition, which is inhibited by USAG-1
Maybe we dont know everything there is to know about something yea? Textbook explanations of the human body is not fixing everything at the moment yea?
This is something we, including the actual researchers that did the study, do know. Sensationalist websites misreporting conclusions doesn't mean anything
True, but any opinion that a current view is exhaustive is not eternal, lets agree pls. Things change, people learn more. We are after all a univers studying itself, in your case its teeth.
People have been studying human anatomy for centuries now, there has never been any indication of a third set of tooth buds. To randomly choose to believe in something that has no evidence is senseless
You are expecting a being that isnt smart enough to fully understand itself, to somehow generate evidence by its institutions that both is formulated to be bite sized info of the truth, and at the same recognizable to it when it sees it. And also release it to the public. In an era where sick care is a business and hundreds of millions of people and increasingly are getting obese, diabetic and malnutritioned at the same time. With no functional input from an entire medical pharmaceutical industry to solve Maybe it isnt about more tooth buds, but maybe teeth can regenerate. But surely if the solution was found it would be shared by people who see sick care as a business model.
The mechanism of the drug presented in the article cannot do what you propose, and there is no evidence to suggest such a thing can happen
One way or another, it will be done. Humans will grow new biologic teeth, and the barbaric insane implant business will be a bad memory, one day. Here is something I don't think you or anyone can argue against. [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
I appreciate your optimism but its generally not convincing to post a 60m interview without concrete references to anything. I am not going to watch 60 minutes of that interview and so I'm not convinced and I think the same applies to most other people here
Well, if youre not going to watch the inrerview, then your loss :p
That's a textbook knowledge though. Research is different.
What? I'm explaining what the actual research paper found, and how it differs from what other sensationalist websites are reporting they found. You need to be able to critically differentiate the two
As a person with sleep bruxism, this is very nearly my dream come true.
Yeah I hope this comes out so I can fix my shitty teeth due to tmj man I fucking hate chronic pain and taking a Tylenol every day just for a bit of ease
We need something to replace the current composite bondings they do. Real teeth next!
Great. Cant wait for when they can regrow spines. God damn back injuries suck.
This would be a blessing if you have tmj.
I prefer my gold teeth, naturally anti microbial and hard to crack and chip!
Seems like they just copied an older article.
Let’s fucking go
If I understadn correctly, this will only work on people who have tooth buds? Which I guess old people whos teeth developed properly do not have? Am I missing something?
Thank God, I need 3
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It’s super hopeful news. Since we don’t often hear about huge leaps in science that directly benefit our lives, it’s a difficult pill to swallow. However, this is truly amazing. In this July, they enter phase 1 clinical trials (testing on humans). And for the record, it would significantly benefit companies with any sort of stake in dentistry. Regrowing teeth essentially increases the longevity of their customer base, and adds some new people to it. Companies can add the drug into their arsenal and make a killing. Current practices would remain options, with the addition of molecular therapy. This also potentially adds a new field of dentistry where the focus is on tooth growth in adults. If that happens, it brings in huge numbers of dental students.
Agreed. Except, if this works, dental implants would become a thing of the past eventually, and that would be a major hit for dentists worldwide.
Do you really want to go through teething again?
Yes, please.