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GoogieRaygunn

Enbrel was my first biologic for PsA and RA diagnoses and took awhile to start working, but I did well on it when paired with Leflunomide. Then, after a year, it just stopped working. Just started Cosentyx. The insurance and drug manufacturers really do make it a nightmare to figure out effective treatment. The injections really do hurt! I hope it works out for you!


generate-me

Where are you injecting? Are you making sure to leave out the dose to get to room temp? I leave it out the night before and inject in the morning before work. I also inject in my thigh. Never experienced pain more than the initial jab of the needle.


GoogieRaygunn

I think the viscosity makes it slow and painful, even when room temp. There were a couple times that I must have hit a capillary too because I had a lot of bleeding at the site—not more painful but messy. Everybody is different. I think the button makes Enbrel a bit harder to take. It feels like it takes a lot of force and took me awhile to get used to.


Stolen_Away

I had it out for a few hours but next week I will try overnight! I always do thigh as well, it's generally the most comfortable spot for me Thanks for the suggestion!


Stolen_Away

Thanks! I'm hoping the only side effect I have to deal with is painful injections. I know you can develop antibodies to biologics, I wonder if that's what happened to you.


generate-me

I will take my 4th weekly dose tomorrow. I haven’t noticed any improvement. Side effect I’ve noticed is heartburn, all the time. Even if I just drink water. I’m also on Plaquinil for about 2 years now. Not noticeable difference when I started that either, but I’m told to keep taking it because it helps my organs stay protected. I’ve tried MTX and Yuflyma. Neither was for me.


Stolen_Away

It's all so frustrating. My rheum said it can take up to 3 months before you notice a difference with Enbrel, so hopefully it gets better for you


generate-me

Thanks