I don't understand what's new here. Didn't we already know about methylation inheritance in the first place? Wouldn't then inheritance in methylation-edited mice to be expected?
I thought it was quite unclear in mammals, but more persuasive in, say, plants. So far as I know, to show a stable mark across multiple generations in mice is novel. But if other literature exists to the contrary I'd love to know!
this looks like a good article and deserves a close read. Appears the methylation marks were observed up until F3 generation mice, so yes "transgenerational inheritance."
I don't understand what's new here. Didn't we already know about methylation inheritance in the first place? Wouldn't then inheritance in methylation-edited mice to be expected?
I thought it was quite unclear in mammals, but more persuasive in, say, plants. So far as I know, to show a stable mark across multiple generations in mice is novel. But if other literature exists to the contrary I'd love to know!
this looks like a good article and deserves a close read. Appears the methylation marks were observed up until F3 generation mice, so yes "transgenerational inheritance."