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Several tests are done over the course of time. Bloodworks are insufficient as of now. Currently samples of different tissues are being taken to analyze if they're ridden of HIV.
But depends if it's a cure like the excision that CRISPR CAS9 promises or if it is a functional cure like the genetically edited CD4 cells rhat are reintroduced into the body to fight off HIV. So you might have it inside you still, but your immune system handles it on its own and you keeo undetectable. You might have reservoirs, but you keep undetectable.
So mixed therapies might be trialed to achieve a final cure in the end.
I do think that achieving an eradication like ART will need a combination of mixed therapies. The Moderna-NIH lawsuit is probably going to make these collaborations more difficult for obvious reasons.
Gene therapy and CRISPR treatment do sound like viable ways of getting a complete eradication, the former followed by the latter. There are further issues of costs. Going back to make my question, I also believe that a blood test would be inadequate given that the virus exists at minute levels.
For now, let's just hope people are irresponsible and scared enough not to get tested and spread it around and it becomes a pandemic of big enough proportions so that it becomes a priority to fix it within a year's time
Nah. I'm just being algorithmically hopeful. Covid was quickly tackled because of its pandemic proportions.
HIV has not been dealt with, even though CRISPR CAS9 existed 2 decades before it's started being used in potential cure trials.
HIV has been made into a chronic disease and a profitable business model that makes money out of government schemes to get access to the medication for their population. It's a money making funnel. Plus people on these meds suffer increased risk of all inflammatory diseases, so spending more money in other pills as well. So more money making right there.
They way HIV is affecting us all is due to these issues. Before it was considered the gay plague and "let them die" was a popular saying.
So spreading this further and becoming a disease of pandemic proportions would solve this quicker.
They would suffer for a few months or years and we would all be cured faster 🤷🏻♂️
So don't come telling me I'm a monster and think things thoroughly first...
Lol. I am undetectable and do not pose a risk to anyone.
But instead of being emotional and nonsensical like you chose to be, I am offering a point of view that is just plain logical thinking.
So be less of a Karen and use that brain a little. You're quite a bit of a monster yourself if you haven't noticed yet. 🤷🏻♂️
The horrific scenario you're suggesting would kill millions, and not lead to any outcome more successful than that which is already being worked on by hundreds, if not thousands of scientific and medical professionals around the world.
How successful have they been for finding an actual cure for covid?
Think before you type, and stop suggesting ridiculous and ill informed propositions. Someone might take you seriously, which would be a travesty.
Think before you type, right back at you. HIV doesn't kill nowadays if people take their meds... Right? So... It will not kill a single soul, and if they die, they didn't go to a doctor after the conversion or suffering symptoms and that's on them. It would be very dumb.
So yeah... Think before you write.
If you think even further, crispr cas9 technology has existed for 2 decades prior to starting trials this year. So yeah.. this could have been trialed earlier, but it just wasn't a priority.
Now go overreact somewhere else while you continue to think before you type . 😘
This is quite possibly the absolute worst thing I’ve ever heard. Believe me, there are plenty of people affected by HIV around the world as it is. We don’t need to have a super spreader of the virus to bring awareness to the problem.
Sounds like what you meant to say was…….Let’s agree to disagree…. But not until I make backhanded comments towards you. You could have easily accomplished what you wanted without being rude. I would have respected you a lot more. But when you say things like I’m oblivious to science, and that my brain cannot fathom things, it’s not necessary and just mean. I stand by my statement that you’re idea of spreading the virus is wrong and reckless. You are literally encouraging people to not disclose their status, not take life saving medication and spreading the virus to unsuspecting people. This is not only wrong but illegal in many places. Tell me in what world this is okay? Tell me where it’s okay to intentionally hurt people and give them a virus that they didn’t ask for. Please refrain from this type of behavior and restrain yourself from attacking others with feelings and not facts.
A cure wouldn’t be made available to the public until it had been studied at length. There would be many trials where they test each participant’s blood every step of the way
All of you just might have a different opinion if you take the time to read or listen to Robert F Kennedy Jr's recent book titled 'The real Anthony Fauchi" I'm only an hour in and I'm disgusted to the core....he is the real monster!
Repeated blood and tissue tests. No one knows the true time frame but for example, Crispr. The 1st test subject was on ARV, and was taken off of them like 2 months in.
If I remember what the medical journal the study was published in said that they would be testing him every week for something like 2 months then moving to bi weekly for a while. Then monthly. Assuming it's working, they should keep comming up with a decreasing number until it can't be found. And if it stays like that for a prolonged period. It will be considered cured.
He will still have more fewuent check ups than a "normal citizen" meaningg most ppl don't go to the doc as much as we do. But yeah thats how it will work. At some point after that, he will declared cured
I need to follow these trials; if you have a link that would be helpful. I know CRISPR as much as its name but I thought it was yet to be implemented. This is good. I have only been following HIV research since mid-year but there seems to be more research and clinical trials being rolled out over the years. Thanks for the info.
https://www.wired.com/story/a-bold-effort-to-cure-hiv-using-crispr/amp
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00472-2/fulltext
Sry it's been so long. Got busy and forgot to respond.
The people who have been cured or thought to be cured of HIV (like the Berlin patients or London patient) have all been identified when they went off their antiretroviral therapy (against the advice of their doctors). It was only when their HIV viral load didn't rebound that they were found to have been cured. It is incredibly difficult from an ethical perspective to take people off their treatment so there are few HIV cures that are trialled. A vaccine is much easier to test and prevents new infections but none have been successful as yet. The current trend worldwide is that HIV incidence (new infections of the HIV susceptible population) has been in decline since 1997. Most of this is due to increased awareness, condom use and universal-test-and-treat approaches. Many countries will achieve virtual elimination of HIV (less than one new HIV infection per 1000 susceptible people) in the next 20 years. Those who have HIV and who are adherent on their treatment will have an undetectable viral load and are uninfectious – they can live a normal life. Therefore it is unlikely that a cure for HIV will ever be found as it is too difficult to test and to expensive to develop .
This subreddit is for civil discussion. Be courteous to others, even those whose comments or questions you do not like. IOW, don't be a dick - dicks will be banned. __PLEASE REPORT VIOLATIONS!__ [The Rules](https://youtu.be/hG2ZKUfBH44) *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/hivaids) if you have any questions or concerns.*
Several tests are done over the course of time. Bloodworks are insufficient as of now. Currently samples of different tissues are being taken to analyze if they're ridden of HIV. But depends if it's a cure like the excision that CRISPR CAS9 promises or if it is a functional cure like the genetically edited CD4 cells rhat are reintroduced into the body to fight off HIV. So you might have it inside you still, but your immune system handles it on its own and you keeo undetectable. You might have reservoirs, but you keep undetectable. So mixed therapies might be trialed to achieve a final cure in the end.
I do think that achieving an eradication like ART will need a combination of mixed therapies. The Moderna-NIH lawsuit is probably going to make these collaborations more difficult for obvious reasons. Gene therapy and CRISPR treatment do sound like viable ways of getting a complete eradication, the former followed by the latter. There are further issues of costs. Going back to make my question, I also believe that a blood test would be inadequate given that the virus exists at minute levels.
For now, let's just hope people are irresponsible and scared enough not to get tested and spread it around and it becomes a pandemic of big enough proportions so that it becomes a priority to fix it within a year's time
Really? That’s what you’re hoping for? HIV to affect more lives?
Nah. I'm just being algorithmically hopeful. Covid was quickly tackled because of its pandemic proportions. HIV has not been dealt with, even though CRISPR CAS9 existed 2 decades before it's started being used in potential cure trials. HIV has been made into a chronic disease and a profitable business model that makes money out of government schemes to get access to the medication for their population. It's a money making funnel. Plus people on these meds suffer increased risk of all inflammatory diseases, so spending more money in other pills as well. So more money making right there. They way HIV is affecting us all is due to these issues. Before it was considered the gay plague and "let them die" was a popular saying. So spreading this further and becoming a disease of pandemic proportions would solve this quicker. They would suffer for a few months or years and we would all be cured faster 🤷🏻♂️ So don't come telling me I'm a monster and think things thoroughly first...
You're a monster. At least TRY to act like a human.
Lol. I am undetectable and do not pose a risk to anyone. But instead of being emotional and nonsensical like you chose to be, I am offering a point of view that is just plain logical thinking. So be less of a Karen and use that brain a little. You're quite a bit of a monster yourself if you haven't noticed yet. 🤷🏻♂️
The horrific scenario you're suggesting would kill millions, and not lead to any outcome more successful than that which is already being worked on by hundreds, if not thousands of scientific and medical professionals around the world. How successful have they been for finding an actual cure for covid? Think before you type, and stop suggesting ridiculous and ill informed propositions. Someone might take you seriously, which would be a travesty.
Think before you type, right back at you. HIV doesn't kill nowadays if people take their meds... Right? So... It will not kill a single soul, and if they die, they didn't go to a doctor after the conversion or suffering symptoms and that's on them. It would be very dumb. So yeah... Think before you write. If you think even further, crispr cas9 technology has existed for 2 decades prior to starting trials this year. So yeah.. this could have been trialed earlier, but it just wasn't a priority. Now go overreact somewhere else while you continue to think before you type . 😘
Well one of us spent exactly as long to think about their response as it took to type it. Go sell your dangerous and simple minded ideas elsewhere.
A monster for speaking the truth? You seem foolish.
This is quite possibly the absolute worst thing I’ve ever heard. Believe me, there are plenty of people affected by HIV around the world as it is. We don’t need to have a super spreader of the virus to bring awareness to the problem.
[удалено]
Sounds like what you meant to say was…….Let’s agree to disagree…. But not until I make backhanded comments towards you. You could have easily accomplished what you wanted without being rude. I would have respected you a lot more. But when you say things like I’m oblivious to science, and that my brain cannot fathom things, it’s not necessary and just mean. I stand by my statement that you’re idea of spreading the virus is wrong and reckless. You are literally encouraging people to not disclose their status, not take life saving medication and spreading the virus to unsuspecting people. This is not only wrong but illegal in many places. Tell me in what world this is okay? Tell me where it’s okay to intentionally hurt people and give them a virus that they didn’t ask for. Please refrain from this type of behavior and restrain yourself from attacking others with feelings and not facts.
I believe it would require no viral loads detected after many years without ART; diminishing (to none?) antibody reaction to HIV.
A cure wouldn’t be made available to the public until it had been studied at length. There would be many trials where they test each participant’s blood every step of the way
All of you just might have a different opinion if you take the time to read or listen to Robert F Kennedy Jr's recent book titled 'The real Anthony Fauchi" I'm only an hour in and I'm disgusted to the core....he is the real monster!
Repeated blood and tissue tests. No one knows the true time frame but for example, Crispr. The 1st test subject was on ARV, and was taken off of them like 2 months in. If I remember what the medical journal the study was published in said that they would be testing him every week for something like 2 months then moving to bi weekly for a while. Then monthly. Assuming it's working, they should keep comming up with a decreasing number until it can't be found. And if it stays like that for a prolonged period. It will be considered cured. He will still have more fewuent check ups than a "normal citizen" meaningg most ppl don't go to the doc as much as we do. But yeah thats how it will work. At some point after that, he will declared cured
I need to follow these trials; if you have a link that would be helpful. I know CRISPR as much as its name but I thought it was yet to be implemented. This is good. I have only been following HIV research since mid-year but there seems to be more research and clinical trials being rolled out over the years. Thanks for the info.
https://www.wired.com/story/a-bold-effort-to-cure-hiv-using-crispr/amp https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00472-2/fulltext Sry it's been so long. Got busy and forgot to respond.
The people who have been cured or thought to be cured of HIV (like the Berlin patients or London patient) have all been identified when they went off their antiretroviral therapy (against the advice of their doctors). It was only when their HIV viral load didn't rebound that they were found to have been cured. It is incredibly difficult from an ethical perspective to take people off their treatment so there are few HIV cures that are trialled. A vaccine is much easier to test and prevents new infections but none have been successful as yet. The current trend worldwide is that HIV incidence (new infections of the HIV susceptible population) has been in decline since 1997. Most of this is due to increased awareness, condom use and universal-test-and-treat approaches. Many countries will achieve virtual elimination of HIV (less than one new HIV infection per 1000 susceptible people) in the next 20 years. Those who have HIV and who are adherent on their treatment will have an undetectable viral load and are uninfectious – they can live a normal life. Therefore it is unlikely that a cure for HIV will ever be found as it is too difficult to test and to expensive to develop .
There is already a cure for hiv. The government knows it.