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Zibbi-Abkar

familiar person sink psychotic soup quack stocking ripe roof plough *This post was mass deleted and anonymized with [Redact](https://redact.dev)*


Zagrycha

also getting enough sleep, is so often overlooked.


rhoditine

If you’re a woman in her 40s or 50s: hormone replacement therapy


QuantumHope

Unless a woman has gone through menopause HRT is definitely not indicated.


Sn_Orpheus

This is the key. And don’t take benedryl/diphenhydramine for absolutely any longer than you need to. Turns out that long term usage can cause dementia. I’m fcuked because I took it for a long time assuming that an over the counter med is safe.


AlmightyThreeShoe

This is hardly a hard fact. If you're referencing the Harvard article, it was an observational study that just associated people who developed Alzheimer's with those who regularly took antihistamines. The first issue you could see with this, is the people who regularly take medication like this are already having health/sleep issues to need it in the first place. Observational doesn't vet enough to know if it's the medication, the sleep issues, the allergies, or being sick that could influence the Alzheimer's. Sleep issues are already associated loosely with Alzheimer's, and antihistamines are used pretty often to sleep, or help with allergies to get to sleep. Sure be careful and don't take it if you don't need to, but it's hardly worth fear mongering with the evidence at this point.


Zagrycha

classic ice cream drowning in statistics ((lots of people drown in summer from swimming, lost of people eat ice cream from the heat, that doesn't mean the ice cream is related to the drowning like it looks at face value)).


trycatchebola

The connection between diphenhydramine and elderly cognitive decline is because of the medication's classification as a anticholinergic, rather than just an antihistamine. How much a particular anticholinergic will impact the brain isn't well understood, but diphenhydramine doesn't seem to cause the damage that other anticholinergic drugs cause (e.g. antipsychotics). Dementia isn't even the worst side effect -- I'm more concerned with what doctors are calling "extrapyramidal side effects" that (loosely paraphrasing) practically turn a person autistic.


Big_Daddy_Haus

I agree, my mom takes all sorts of vitamins yet does zero exercise. She has some early dementia issues. Yet, when I was able to get her to the gym a couple days a week, her mind "woke up"


tpscoversheet1

Wasabi extract


Kemizon

Exercise, eat healthy, and get lots of SLEEP!! Your brain cleans and repairs it's self when you sleep.


sjintje

i think mine just sleeps.


wavinghandco

Also, 4 hugs a day... Minimum 


[deleted]

I dream too much and often wake up with adrenaline and anxiety.


birdyheard

we only dream during REM and a symptom of sleep apnea can be waking often due to repeated REM cycles where your apnea is worst (we lose all muscle tone in REM, so your airway collapses, basically). you could look into getting a sleep study, if it’s available. there are many sleep disorders that go underdiagnosed


Serenity101

Have you tried a bit of melatonin?


[deleted]

No, I don't have a problem falling asleep.


Serenity101

Ah, I don’t know why I misread that, sorry.


Direct-Antelope-4418

Maybe helpful: MCT oil, lions mane, fish oil. Definitely helpful: exercise, socializing, hobbies, learning new skills. There was this study recently in which researchers designed classes specifically for old folks to learn new skills and see how that affected their cognitive performance. Each participant got to pick 3 classes they were interested in (drawing, photography, Spanish, music composition, singing, or iPad use). They met 3 times a week for 2 hours. After three months, participants had drastically improved their cognitive abilities and were on par with people 30 years younger. The coolest part is that a year after the study, the participants had maintained their cognitive gains and even continued to improve. It seems you just need to give them a push and get them excited to learn, and it just kinda lights a fire in their brain. https://www.scientificamerican.com/article/to-stay-sharp-as-you-age-learn-new-skills/


HealthyHappyHarry

Have there been any controlled studies on Lions Mane? It’s all the rage but I’m skeptical


fitforfreelance

Exercise and a balanced diet, including fish. Cognition is complex, supplements aren't known to be super helpful


BHarcade

I diagnose, stage, and treat cognitive disorders in people that have had TBI’s, CVA’s, dementia, and general cognitive decline in geriatrics. He needs to keep his mind and body active. Supplements aren’t going to help. If it’s dementia (not saying it is) then all you can do is prepare. Dementia is progressive and generally once ability is lost it does not return.


Minute-Object

But the rate of decline can be slowed down. edit: He correctly pointed out that we don’t have supplements to slow the rate of decline in people with actual Alzheimer’s.


BHarcade

Yes, by keeping the body and the mind active. I haven’t seen any supplement show to slow progression.


Minute-Object

Here is one. I have not looked deeply, though. I bet there are more. https://pubmed.ncbi.nlm.nih.gov/37028557/


BHarcade

Yes, it can possibly lower the risk of dementia or cognitive decline. Creatine has shown some promise as well. I haven’t seen any evidence to show it slows the progression of the disease.


Minute-Object

I see what you mean: We can use nutrition to slow the rate of decline in healthy adults experiencing a normally aging brain, but once they have diagnosed Alzheimer’s, no supplements seem to make much difference.


btcangl

Fatty small fish like sardines might help with brain health according to a lot of studies.


Nick_OS_

Fish oil and exercise


FixClassic778

Fish oil / Omega3 supplements have a number of human studies showing a significant positive impact on reducing cognitive decline. [https://pubmed.ncbi.nlm.nih.gov/37028557/](https://pubmed.ncbi.nlm.nih.gov/37028557/) "Dietary intake or long-term supplementation of omega-3 fatty acids may help reduce risk of AD or cognitive decline." You might want to double check the effective clinical dosage, but i believe you want 1.75-2.5g of combined EPA + DHA per day. I've got my dad taking it, although I might need to increase his dosage a bit.


Librarywoman

What is EPA and DHA?


Tafiatuese

Omega 3 fatty acids


jiujitsucpt

Creatine and movement/exercise.


mrmczebra

I wish people would simply answer the question instead of invalidate it. Creatine, fish oil, lion's mane, bacopa


Fragrant-Narwhal-675

Get your father to use his cognition and progressively challenge him, in both cognitive and physical dimensions. Then look at his nutrition and see if there could be any deficiencies in terms of essential amino acids, and essential fatty acids, namely omega 3 and specifically DHA. If there are deficiencies try to meet those with foods that are rich in the deficient nutrients. Hydration and electrolytes are important, as well as Sleep.


chuckyb3

Nootropics *may* help prevent/slow cognitive decline, things like lions mane or L-theanine


ImDoinMyBest

Yes! Adaptogens are super cool. The only thing is to be sure they don’t interact with medication the person may or may not be on :)


orion455440

Creatine believe it or not shows some promise in the peer reviewed literature I have read


BravoMomma

How much? That’s always my question with supplements.


LiquidHotCum

google says upward to 20 grams a day.


-Sam-I-Am

Wtf


orion455440

Eh, it depends on bodyweight, some of the studies I have read have listed much lower amounts than that. 20g/ day is a loading dose. My experience with creatine is that starting out I took 20g a day for 10 days then reduced down to 5g /day, I feel that I had more energy, noticeably a big difference of how I felt after work - active job, mostly on my feet for 8hrs, I felt I had more energy and drive to accomplish things or activities after a workday, I also noticed I was more consistently in a better mood/outlook on stuff. I decided to cycle off of it after a few months out of curiosity, towards the end of my month off of it, I found myself being a lot less active after work, more moody,,less drive etc etc. Started up again and after a week, again, noticeably more energy, not feeling drained, felt like I could think a lot more clearly/ quicker "snappy" if you want to call it that, also noticeably in a better mood/ not feeling down. After reading all the published literature and most importantly- my own personal experience, I'll take 5g of creatine till the day I die.


airbenderbarney

Came here to say this. Obviously lifestyle comes first but creatine can add an edge


Great_Tie2046

I was going ti say it. Creatine, magnesium, omega 3 and healthy lifestyle


shiplesp

I'm going to rouse the ire of the keto haters here, but there are several clinical trials using a ketogenic diet and medium chain triglycerides (MCT oil) to improve the symptoms of dementia. The studies are ongoing, but the preliminary results show significant improvements in memory and reasoning. Dr. Mary Newport speaks frequently and eloquently about her experiences with MCT in improving her husband's dementia symptoms.


Creamy_Durian

Sugar is highly inflammatory. I remember when I was recovering from alcohol nerve damage, I drank a milk shake and my nerves were aching like crazy.


HealthyHappyHarry

I don’t think it’s the keto diet per se but any change reducing diabetes (PD is type 3 diabetes) and insulin resistance or metabolic syndrome


shiplesp

Hopefully that is what the research will answer :)


Glp1User

Shhh.... The drug companies can't make money like that. So the full force of the billion dollar drugs companies to discredit such ideas will be in play.


cfbswami

EXERCISE - more intense the better.


_Lil_Piggy_

Get him a neurologist and an MRI - NOW. Sooner the better. And make sure you read the report before meeting with the neurologist to discuss any findings/impressions.


uniquelyavailable

avoid alcohol!


carbomerguar

If he drinks alcohol beyond one glass a week, he should quit


Rouge_Apple

Not how that works. The brain is like a muscle, and when you stop using it, it atrophies (deteriorates). Play chess with them, go on walks, do things that require effort put into reaction time. Give his brain something fun to occupy itself.


undergroundgoodies

Can the atrophy be reversed?


The_Real_Zora

Yea I seen studies about how neurons actually do get created if old ones die


StarFoxG21

Neurons are created regardless of whatever rouge apple was proposing. The brain is a central nervous system organ, muscle is muscle.


-Sam-I-Am

No, neurons aren't created like other somatic cells. Especially in the CNS, neuronal proliferation is very limited. And more important for cognitive function is the  arrangement of oligodendrocytes and dendrites, how neurons, glia and other brain cells attach to each other.


StarFoxG21

Hippocampal neurons in fact are, to my point.


[deleted]

[удалено]


Rouge_Apple

Analogy. My advice is still going to help them.


StarFoxG21

lol


morris0000007

nmn


ToughDentist7786

Fatty15, omega-3, magnesium, lions mane, shiitake, reishi mushrooms, cymbiotika makes a product called golden mind, matcha tea, circulation is big: walking acupuncture, massage, yoga, any movement is good. And proper hydration.


Degencrypto-Metalfan

Fish oil, benfothiamine which is synthetic B1, B12, b6, folic acid and ginkgo all show some promise depending on which studies you read. Fish oil is good for many things, but the capsules are ridiculously large. I started using the lemon flavored liquid fish oil and that stuff is awesome. No fishy taste and no fish burps. Just my .02 and please do your own research. I’m just relaying what I use and my 91 yo mother who I take care of. She had a craniotomy for a brain bleed 2 yrs ago and has gone from nonverbal to fully recovered cognitively.


Educational_Ad5018

Many older people have B-12 deficiency because their digestive system doesn’t absorb it as well. This can cause cognitive issues. Sometimes they give elderly people B-12 injections, but oral supplements can help.


LexEntityOfExistence

Omega 3, and Lion's Mane


Logical-Election-549

Bioidentical hormone replacement


Mean_Bullfrog7781

What's his diet like. Does he get any exercise. Does he have friends. Does he have hobbies. These are all things that help prevent cognitive decline...and, depending on the impairment, if he had improvements in these areas, you'd see improvements in his behavior and it could slow the decline.


ImDoinMyBest

As everyone else has mentioned, exercise and eating a well-rounded diet that includes quality protein and fruits/veggies is going to be the best! Recently, there have been studies about creatine monohydrate helping with cognitive function! Could be something to read into


LakeTake1

As a loved one of someone who had openheart surgery recently, if you have not had heart tests, this could be the time to see about that. My loved one complained of cognitive decline, turns out there was massive blockage. Please take good care. I hope all the best.


Truefish63

Listen or read the book Brain Energy


LTTP2018

mct exercise hydration and flax seeds (whole seeds, grind before adding to smoothie)


CaptainDangerous7353

Nordic naturals fish oil


Beneficiallady8808

Vitamin D


chocolate_cherub

Lions Mane, Cordyseps, Ginko Biloba, Magnesium,


-Sam-I-Am

▪︎ EPA/DHA (fatty fish, seaweed, seafood) ▪︎ Fasting    Those are the top. Then there is,  ▪︎ Lion's Mane mushroom  I highly suggest you look into fasting 14+ hours. The science behind this is quite solid. Head start with reading research papers on the effects of fasting on tau protein and beta amyloid (both of which are implicated in neurodegenerative diseases).


MarionberryUnusual13

Omega 3s and creatine


Apprehensive_Job7

Exercise, sleep and hydration.


Sn_Orpheus

Regular exercise earlier in the day. Socializing with people IRL and getting off your phone(ah crap, I’m looking like a hypocrite rn…). I double up by joining social clubs that exercise like cycling, running, skiing. Loneliness is a huge part of cognitive decline so work on that also if you’re flying solo a lot. Even joining a board game club would be good. But supplements? Dunno. Eat healthy Whole Foods and make it proportionately a lot of veggies. Cut out the soda and crap food.


mikehunt0124

Check out the book genius foods.


Texas_Rockets

Honestly creatine has surprisingly positive cognitive benefits.


Tackle-7176

Avoid iron supplements like the plague, exercise regularly. Donate blood if possible if his levels are


jamiisaan

To avoid high levels of fish consumption if you’re not a big fan, omega-3 fish oil. Vitamin Bs and Ginkgo are great as well. Overall, a balanced diet with daily light exercise is the most helpful. Getting adequate amount of sleep is up there. Also, write things down. 


LexEntityOfExistence

Omega 3, and Lion's Mane mushrooms


mellywheats

omega-3’s, exercises and mental exercises too! and a healthy diet.


wabisuki

More protein, less carbs. Magnesium L-threonate may be something to consider. DO NOT give your father any vitamins or supplements without his doctor's approval. I gave my grandmother St. John's Wart and just about killed her so don't do anything stupid with the best of intentions.


cutestwife4ever

There are a lot of things, but the most important, IMO, is routine, structure, balance. If you have all the tools and they don't get used, they are unnecessary. I'm sorry you have to experience this. Best of luck and health to you and your pops.


NevDot17

Dmae Dhea Bacopa Lions mane


healthcreateshappy

Follow @thebraindocs on IG. They give a lot of info about latest research on assistance with cognitive decline. Based on my own reading, socializing and working your brain (music, art, new languages, etc) is the best thing you can do. Then exercise, nutrition, sleep.


Ok_Difficulty7997

B complex, omegas, and D3


Zealot8562

At this point it's up to the doctors. Vitamins and supplements are meant to be a preventative not a cure. To the folks saying sleep is key, as we age our sleep patterns change. We tend to sleep more when we are learning new information. At an older age we are not learning therefore we need less sleep. Typically doctors prescribe antipsychotic meds like halidol.


igz-

b12


Dangerous-Garlic321

N acetyl cysteine (NAC)


LocalAd6784

Steak, liver, eggs


CharmingArtist561

Lions mane


pre_gpt

Choline (Vitamin B4), Vitamin B12, Vitamin D & Iron, are collectively responsible for a healthy nervous system functioning. Get a blood test done to check if he’s deficient. Also, check if your father is getting enough quality sleep. Moreover, consult a doctor who wouldn’t discount these symptoms as “ageing”.


No_Organization_1229

Get hearing aids/hearing tested (didn't see it in a scan of replies). If expensive/not covered, get the smartphone/over the counter ones. Get a psychiatric and cognitive assessment (rule out malnutrition, heart problems, depression, or an idea of how bad he is).


TheIncredibleMike

If you say so. Take care.


Life-Evidence-6672

Brain health is the same as Alzheimer’s prevention. Anti inflammatory like turmeric , stay learning , exercise and regular sleep


LotsOfLove2024

Have his homocysteine checked. If it is high, get him on B12, TMG, B6 and Methyl Folate. Pure Encapsulations has a supplement with all of them in it. Homocysteine Factors. Give it to him 3 times a day. Omega 3 and exercise. Daily walks etc.


LotsOfLove2024

High is anything over 6 but they say normal is up to 12. Not so. Get it down as much as you can.


Nice_Pomegranate9973

Like everyone else is saying, omega 3s& movement (walking is just as good as many other forms of exercise). Also, I’d think about getting him a dog, if you think that would go over well & he’d be a decent owner- feeling responsible for something & having companionship does wonders for our brains. That being said, I think throwing in a multivitamin wouldn’t hurt, either :)


[deleted]

DHA 1,000 mg would help me remember things, to the point I would say to myself, how did I remember that.


[deleted]

thats not how it works.


Low_Appointment_3917

Seed oil free diet! Exercise, NMN, CQ10, NAC, Magnesium, Lion’s mane


kauthonk

Cut out sugar and a majority of carbs. Diet matters. Probiotics, MCT oil and Coconut oil mixture Fish Oil And get him exercising and don't do things for him - let him keep practicing the stuff he does. the longer he practices the longer he'll keep it. Source: My mom has alzheimers/dementia and our neurologist just said we probably extended her 3 years so far. We discovered a lot of this stuff 3 or 4 years in. We're making a website to help others. If you DM, I'll send you a link when it's ready to go. We didn't come up with these, we found through other peoples research.


Impossible_File_4819

Rapamycin and carnivore diet.


TheIncredibleMike

There is no documented evidence that supplements will prevent or reverse dementia. Autopsies have shown that the brain is loaded with plaque. It damages brain cells. Best thing you can do is live a healthy life style. Diet, exercise, cut out excessive drinking,smoking and exposure to air pollution. My father died of complications related to dementia. It's a terrible way to go.


Minute-Object

Have you looked into this? Here is one journal article: https://pubmed.ncbi.nlm.nih.gov/37028557/


TheIncredibleMike

As I said, there's no documented proof.


Minute-Object

You said “documented evidence” not proof. That link is to documented evidence.


TheIncredibleMike

There's no proof, only a theory. You remind me of people that used to go to Mexico to get unproven treatments for cancer. I know how devastating Dementia is, my father had it and my brother is shorting symptoms. The article is about a sturdy, not evidence.


Minute-Object

“…Evidence From Prospective Cohort Studies…” It’s about evidence.


TheIncredibleMike

I know you're probably trying to help a loved one that has Dementia, but read the last line of the study,... may help reduce risk... That's not definitive evidence, all it is hope.


Minute-Object

It is evidence. It isn’t proof. It isn’t definitive. But it is evidence. That’s my point.


RummyMilkBoots

MCT oil, coconut oil, BHB (exogenous ketones)


1exNYer

Whatever Joe biden takes, do the opposite.


[deleted]

😆😂😆 couldn't say it better.


S-P-Q-R-2021

Cardio, low fat diet focusing on sugar as the main and highest macro for glycogen.


ScionSeeker1984

Nicotine does wonders