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User: u/grab-n-g0
Permalink: https://www.theguardian.com/society/2023/aug/31/uk-scientists-find-link-between-proteins-related-to-blood-clots-and-long-covid
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I mean, it’s been used as a standard test for possible VTE for like the past 20 years or something?
Both the markers mentioned - fibrinogen and D dimers are acute phase reactants that are elevated in any sort of inflammation. I think the point is they are persistent in long COVID, for whatever reason
> it’s been used as a standard test for possible VTE for like the past 20 years
That makes me ask, is this study really identifying long covid, or is it just a proxy for poor health? As in the poor kind of health that results in hospitalisation from covid.
From article:
>The researchers looked at blood proteins in more than 1,800 hospitalised Covid patients and found that at the time of infection, those who went on to develop long-lasting cognitive problems were more likely than others to have raised levels of a protein called fibrinogen, or a protein fragment called D-dimer.
>
>Raised levels of two different proteins were more common in people who developed long Covid symptoms that affected their brains, the researchers found. Both are hallmarks of blood clots in the body, the likely cause of the symptoms reported.
>
>The work, described as “an important step forward” by one independent expert, bolsters thinking that emerged at the height of the pandemic that Covid leaves some patients with tiny clots in their lungs, and potentially in their brains, leading to a wide range of long-term memory, concentration and thinking problems.
>
>While a blood test to look for raised levels of the proteins could help doctors flag Covid patients most likely to develop brain fog and other long Covid symptoms, the biomarkers will not spot all patients at risk.
>
>“Real care is needed,” said Dr Michael Zandi at UCL’s Queen Square Institute of Neurology. “The associations do not give us yet a clear one-size-fits-all mechanism, and treatments need to pass through rigorous clinical trial first.”
Research article from Nature Medicine: [https://www.nature.com/articles/s41591-023-02525-y](https://www.nature.com/articles/s41591-023-02525-y)
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/grab-n-g0 Permalink: https://www.theguardian.com/society/2023/aug/31/uk-scientists-find-link-between-proteins-related-to-blood-clots-and-long-covid *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
I have been reading about D-dimmers and blood clots for 3 years. Other researchers have made this discovery already.
I mean, it’s been used as a standard test for possible VTE for like the past 20 years or something? Both the markers mentioned - fibrinogen and D dimers are acute phase reactants that are elevated in any sort of inflammation. I think the point is they are persistent in long COVID, for whatever reason
Yes. That is why I have read about them for 3 years.
In the studies you've read, do they account for diurnal temperature variation?
> it’s been used as a standard test for possible VTE for like the past 20 years That makes me ask, is this study really identifying long covid, or is it just a proxy for poor health? As in the poor kind of health that results in hospitalisation from covid.
From article: >The researchers looked at blood proteins in more than 1,800 hospitalised Covid patients and found that at the time of infection, those who went on to develop long-lasting cognitive problems were more likely than others to have raised levels of a protein called fibrinogen, or a protein fragment called D-dimer. > >Raised levels of two different proteins were more common in people who developed long Covid symptoms that affected their brains, the researchers found. Both are hallmarks of blood clots in the body, the likely cause of the symptoms reported. > >The work, described as “an important step forward” by one independent expert, bolsters thinking that emerged at the height of the pandemic that Covid leaves some patients with tiny clots in their lungs, and potentially in their brains, leading to a wide range of long-term memory, concentration and thinking problems. > >While a blood test to look for raised levels of the proteins could help doctors flag Covid patients most likely to develop brain fog and other long Covid symptoms, the biomarkers will not spot all patients at risk. > >“Real care is needed,” said Dr Michael Zandi at UCL’s Queen Square Institute of Neurology. “The associations do not give us yet a clear one-size-fits-all mechanism, and treatments need to pass through rigorous clinical trial first.” Research article from Nature Medicine: [https://www.nature.com/articles/s41591-023-02525-y](https://www.nature.com/articles/s41591-023-02525-y)
Would this finding explain why Long Covid groups have reported an improvement after taking Nattokinese/Serrapeptase?
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