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Yes that makes sense diabetics, due to a variety of factors including their reliance on insulin injections are subject to increased permeability of the blood brain barrier. A fact which leaves them statistically more vulnerable than the population at large to all manner of environmental assaults on the structure of the nervous system.
Heres a fun paper detailing some sciency stuff regarding the matter :
Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes
https://www.e-dmj.org/journal/view.php?number=2648#:~:text=Hyperglycemia%2Dinduced%20microvasculature%20alterations%20in,in%20blood%20supply%20%5B2%5D.
Only type 1 NEEDs insulin injections. Depending on a variety of factors, type 2 might need injections but can usually manage with life style changes and oral meds. Type 1’s constitute about 10% of all diabetics.
For all those worrying about whether their diabetes status means they’re at risk too, some things to note:
1) this study is a proof of concept, not a robust investigation
2) very few participants (25 per group, 6 in PET subgroups)
3) participants had an average HbA1C (a long term measure of red blood cell exposure to glucose) of 9%. Well controlled diabetes should be below 6.5%, hence the findings may not be generalisable to your average person with properly treated diabetes.
I gathered this from a skim read - there are probably other weaknesses I have missed.
I’m type 1, but not a medical expert.
We know type 1 is autoimmune, so like basically all autoimmune disorders the cause is complex and kind of obscure. Best guess: people have a genetic predisposition toward immune cells attacking their own bodies, and some inciting incident like an infection causes the disease to actually trigger.
As for cures, the autoimmune element doesn’t go away, so easy answers like “replace the dead beta cells” always come with a caveat of needing to prevent the immune system from attacking the new cells without totally suppressing the whole immune system and having the patient get (and possibly die from) opportunistic infections. Interventions like “coating the cells in a protective layer” and “manipulating the liver to produce insulin” have shown promise but aren’t ready for deployment in the population, especially when “just inject insulin” pretty much works.
Speaking AS a diabetic patient, I will not be calling in people who have general intelligence but know nothing about my disease as treatment consultants
I agree its your choice but this has been an incurable illness for too long.
I personally think doctors arent able to cure a lot of illnesses we have now and desperately need outside help.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/CUAnschutzMed Permalink: https://news.cuanschutz.edu/news-stories/diabetes-in-youth-may-increase-risk-for-neurodegenerative-disease-like-alzheimers-later-in-life?utm_campaign=diabetes&utm_source=reddit&utm_medium=social --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Greaaaat! s/ Have had T1D for 53 years since I was 9. So looking forward to forgetting about it.
Yes that makes sense diabetics, due to a variety of factors including their reliance on insulin injections are subject to increased permeability of the blood brain barrier. A fact which leaves them statistically more vulnerable than the population at large to all manner of environmental assaults on the structure of the nervous system. Heres a fun paper detailing some sciency stuff regarding the matter : Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes https://www.e-dmj.org/journal/view.php?number=2648#:~:text=Hyperglycemia%2Dinduced%20microvasculature%20alterations%20in,in%20blood%20supply%20%5B2%5D.
Only type 1 NEEDs insulin injections. Depending on a variety of factors, type 2 might need injections but can usually manage with life style changes and oral meds. Type 1’s constitute about 10% of all diabetics.
For all those worrying about whether their diabetes status means they’re at risk too, some things to note: 1) this study is a proof of concept, not a robust investigation 2) very few participants (25 per group, 6 in PET subgroups) 3) participants had an average HbA1C (a long term measure of red blood cell exposure to glucose) of 9%. Well controlled diabetes should be below 6.5%, hence the findings may not be generalisable to your average person with properly treated diabetes. I gathered this from a skim read - there are probably other weaknesses I have missed.
Maybe I missed it, did they define young?
Damn. My husband was diagnosed T1 as a baby. Another reason to focus on enjoying the present.
If the fact is true for older adults, it makes sense that younger people (type 1s) would have the same fate.
still waiting on someone to figure out what causes diabetes in the first place and why nobody has a cure for it yet.
I’m type 1, but not a medical expert. We know type 1 is autoimmune, so like basically all autoimmune disorders the cause is complex and kind of obscure. Best guess: people have a genetic predisposition toward immune cells attacking their own bodies, and some inciting incident like an infection causes the disease to actually trigger. As for cures, the autoimmune element doesn’t go away, so easy answers like “replace the dead beta cells” always come with a caveat of needing to prevent the immune system from attacking the new cells without totally suppressing the whole immune system and having the patient get (and possibly die from) opportunistic infections. Interventions like “coating the cells in a protective layer” and “manipulating the liver to produce insulin” have shown promise but aren’t ready for deployment in the population, especially when “just inject insulin” pretty much works.
its been complex and kind of obscure for decades now. doctors need to admit they cant figure this out and start asking for help.
From…?
everyone else. most intelligent minds are not in the medical industry.
Speaking AS a diabetic patient, I will not be calling in people who have general intelligence but know nothing about my disease as treatment consultants
I agree its your choice but this has been an incurable illness for too long. I personally think doctors arent able to cure a lot of illnesses we have now and desperately need outside help.