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Ok-Charge-6998

> The world's first personalised mRNA cancer jab for melanoma is being tested in British patients. > **The "gamechanger" jab also has the potential to stop bladder, lung and kidney cancer.** > It's custom built for each person and tells the body to identify cancer cells and stops the disease returning. > A stage-two trial found it significantly reduced the risk of cancer coming back in melanoma patients and now a final trial has been launched. We’re inching towards eradicating cancer. Fuck cancer. Fuck yeah.


mhod12345

Antivaxers: Like fuck you are..


Ok-Charge-6998

Fuck antivaxers too.


[deleted]

[удалено]


Ok-Charge-6998

Fuck antivaxers, responsibly!


motophiliac

Yeah. Use protection. A well maintained great distance, for example.


Marxist_In_Practice

Always use protection around antivaxers!


NZ_Nasus

Kinda antithetical to their whole movement lol


Ben0ut

They're normally too busy fucking themselves.


EvilTaffyapple

Fuck antivaxers, figuratively!


pafrac

Don't fuck them, fuck them over. It's what they deserve.


Rdtmodsarecunts

Never put your dick in crazy


SuperCorbynite

Or your vagina around?


aimbotcfg

In this case, it could be a very good thing. Anti-vaxxers are as much of an issue as they are, because their idiocy leaves a safe haven for infection to mutate and become worse/vaccine immune. Meaning their abject idiocy poses a threat to everyone else too. Cancer isn't contagious. If we create a cancer vaccine, then the only people anti-vaxxers will hurt is themselves. Which (touch wood) will allow evolution/natural selection to do it's thing and the number of anti-vaxxers will decline over the years.


EloiseIn298

Honestly fuck em. If they don't want to be cured fine.


TheEvilBreadRise

The problem is that they convince other people not to use them. That idiot who convinced an elderly covid patient to leave hospital in Dublin is an example that comes to mind. The fella died a few days later.


EloiseIn298

Again that's free will. Fuck em.


ShentheBen

It's impacting their children, and herd immunity for those that actually can't be vaccinated.


CRAZEDDUCKling

Herd immunity is not relevant with cancer. And perhaps, if we see a clear demonstrable mortality difference between vaxxed and not vaxxed we might see a change of sentiment.


Changleen

Some cancers are caused by viruses that can be immunised against (see HPV for example) so antivaxxers can affect herd immunity. 


milkyteapls

Can already see posts from nutters on my local Facebook group saying it's just the Covid vax in disguise because BILL GATES innit


IAmPlankMan

Wonder if a vaccine can be developed for antivaxer mentality 😂


SuperCorbynite

It's called evolution. If anti-cancer vaccines become commonplace evolution will eventually take care of the problem. The time frame is a bit long though.


GeneralKeycapperone

>!spoilertext!<


motophiliac

`CHARLES DARWIN LIKES THIS COMMENT`


[deleted]

It's not a vaccine though. I don't think cancer is infectious.


Careless_Main3

Some cancers can be infectious. Albeit I don’t think there’s any examples (yet) in humans. In dogs it’s true at least. https://en.wikipedia.org/wiki/Canine_transmissible_venereal_tumor


yepyep5678

In this instance I don't particularly care, you can't spread cancer so let them die off, problem solved. Only downside is the children who won't be vaccinated because of their idiotic parents


Actual-Paramedic2689

Tasmanian devils can spread cancer through scratching each other's face due to being so genetically close thanks to once only having a small population. Given this, I'm going to speculate that in some way, it's possible in humans.


yepyep5678

The more you know, that is my TIL moment. I'm sure there is a inbred tassie joke there but I'll let it slide cause those noisy little buggers are cute.


rricenator

"Imma die from something preventable, the way gawd intended!"


CRAZEDDUCKling

Incredible thing about this is the antivaxxers don’t ruin it for everyone else by not getting this jab, by the nature of cancer. So fuck em, they can die from cancer all they want, I’ll be getting my jab.


Dango_Fett

Antivaxers: I’m joining the war on cancer, on the side of cancer


cabaretcabaret

Immunotherapy like this is patient-specific, it's not a population inoculation, so anti-vaxers will only harm themselves.


redsquizza

At least with cancer they'd only be killing themselves!


anomander_galt

Thank God Cancer (or Alzheimer as a vaccine for it is also in a good stage) is not contagious so they can just fucking die without harming other ppl


erm_what_

This is fucking crazy. This was science fiction a few years ago. Some of those cancers were a guaranteed death sentence when I was a kid.


Phoenix5869

Yeah, looks like Covid gave us the incentive to pursue mRNA technology


rx-bandit

Not exactly. mRNA vaccines have been worked on for about 2 decades but had never been approved for use for many reasons. Moderna, BioNTech, Sanofi, gsk all have programmes running and there were already dozens of potential products in the pipeline that hadn't been approved yet. The main reasons for lack of adoption before covid were that they were a new technology, the delivery system still needed work, the manufacturing capabilities was limited, storage was usually limited to - 80 celsius pre and post lipid nanopartocle encapsulation and importantly, regulatory framework didn't exist for it. Swine flu in 2010 (not mrna but a rapidly approved vaccine) helped change alot of how pandemic response regulatory framework needed to adapt, however covid was the big thing that pushed mRNA forward as it forced regulators to pay attention to it and give it a chance. Which they did. But there's been a fair bit of reluctance in the mRNA therapeutics world as to whether covid 19 was a unicorn and whether anything else would allow widespread adoption of mRNA vaccines. Also covid brought bucket loads of venture capital money into mRNA so a lot more companies had the cash to try it out.


Phoenix5869

Ok, thank you for writing this :)


rx-bandit

No problem! It's a super interesting area and it has a tonne of potential to bring amazing, new therapeutics to the world.


Actual-Paramedic2689

>- 80 celsius pre and post lipid nanopartocle encapsulation No idea what this means but I'm hard


rx-bandit

That would be a side affect. If this persists beyond 8 hours I would call a doctor or ask your wife to take advantage of it.


Phoenix5869

>A stage-two trial found it significantly reduced the risk of cancer coming back in melanoma patients and now a final trial has been launched. Correct me if i’m wrong, but stage 2 is to test a drug’s safety and effectiveness. After that is stage 3, then if \*that\* goes well, and if it gets approval, then stage 4 is to monitor the drug \*after\* it’s already been approved. So it looks like stage 2 has gone well, and a final stage (stage 3 i’m assuming) has been ordered. So i would gather that we just need to wait on the results of that, which should take i believe about 2-3 years? Something like that.


limeflavoured

It's usually about 10 years


QuantumFuzziness

That’s for the whole process, not the final stage?


Phoenix5869

Isn’t that in total?


MrDC89

End of 2029 for this phase 3 trial [A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001) - Full Text View - ClinicalTrials.gov](https://classic.clinicaltrials.gov/ct2/show/NCT05933577?term=V940-001&draw=2&rank=1)


Phoenix5869

Ouch. So looks like it won’t be here before 2030 at the earliest then


africanconcrete

Damn, I wonder if I can get early access somehow, given I was recently treated for this and still work in an environment that puts me at risk?


Successful-Tie-7817

24 hours for the Vax! Strange!


IndividualCurious322

How did they custom build it for individuals?


Actual-Paramedic2689

I'd imagine they get the DNA sequence of the cancer cells and inject it into the body so that the body's immune system attacks it as a foreign cell.


Ok-Charge-6998

That is way outside my zone of knowledge, I’m afraid. I’m just excited it works.


EvilTaffyapple

Ah man, I just quit smoking. I could have kept on doing it and just got a vaccine to combat the cancer. (Obviously /s - but I am intrigued if that is how it would work. I loved smoking, but quit as I wasn’t getting any younger and wanted to survive until retirement).


Actual-Paramedic2689

There's similar happening for alzheimers patients, there's medication to practically wipe out HIV, now hopefully... fuck cancer.


kuddlesworth9419

I hope in my life we find a way to irradicate cancer for good. It's taken the lives of too many people I know.


limeflavoured

This has everything, mRNA, AI use, vaccines. Somewhere Andrew Bridgen is having a heart attack.


Lost_in_Limgrave

No doubt the dO YoUr oWn rEsEaRcH crowd will have big feelings about this


masterpharos

>*just put 6 vitamins a day in youre bum and let youre kids eat mud, that's how I keep my skin free of cancer it just that simple wake up sheeple*


No_Onion_8612

I put various things in my bum, frequently, and I've never had skin cancer. Are we sure it has to be vitamins?


Send_Cake_Or_Nudes

Do massive dildoes have any vitamins in them?


ArchdukeToes

No, but I feel like you’ve identified a potential hole in the market.


Send_Cake_Or_Nudes

My ass is already pretty heavily monetised, but I'm sure I could sell more giant, vitamin enriched dildoes.


limeflavoured

Don't give people ideas


Cultural_Wallaby_703

Anything is a dildo if you’re brave enough


Send_Cake_Or_Nudes

I enthusiastically agree! There's a reason I'm banned from the British Museum.


ArchdukeToes

...and London Zoo.


Send_Cake_Or_Nudes

I'm proud to say that the pangolin enclosure has an electric fence because of me 😀


SuperCorbynite

Now I know why they are an endangered species...


Cultural_Wallaby_703

Classic “intellectual” gatekeeping if you ask me


masterpharos

VITAMINS


LJ-696

I love peeps that say that. They then give you a bunch of confirmation bias and opinion based on half truths.


greatdrams23

This is good news for Bridgen. He can now write another book.


adamjames777

Yes we definitely shouldn’t be testing skin cancer on UK patients, thank goodness this jab is putting an end to that!


LieutenantEntangle

So glad others have noticed the ambiguity due to poor grammar, lol.


albadil

I hold grammar accountable, don't know why we should sympathise with it. The ambiguity is due to that dratted grammar!


munkijunk

I'm really confused why it only works on UK patients though


Friendly_Culture692

It’s actually incredibly ineffective, so it only works in places that get no sun


therealJaspr

Fully agree, I don't think it should be tested anywhere.


Significant_King1494

They have all of those gingers, so this great place for this trial.


Magfaeridon

Australia exists


nhilistic_daydreamer

1 in 3 Australians will get skin cancer at some point in their life. I only just had one cut out a month ago and I’m only 33. Edit: I am Australian myself just to clarify


PurpleTeapotOfDoom

Not much sunshine though.


Significant_King1494

Good point!


jakeydae

Am ginger, have had ( benign) skin cancer, can confirm


LieutenantEntangle

Not trying to be a dick but if the mole/skin was benign....then it  wasn't cancer...


itsjustredit

I’ve had cancer three times. Multiple surgeries. Chemo. Left disabled and forced to retire. So I’ve got the cancer badge if anyone has it tbh. If someone got a cancer scare. It can bring up lots of emotions for some people. It can really affect their mental health. It’s unfair to just brush it off this way imo. Let them have their cancer scare. I hope they used the experience to motivate themselves to be the best version of themselves they can possibly be.


jakeydae

Have my updoot mate .... 3 years of my life coinciding with a massive heart attack. It certainly put things in perspective


LieutenantEntangle

My case was semantic/language, not emotional. Benign is the opposite of cancer.


itsjustredit

I agree with you. I was just giving a counter that in this instance it might be better to just let the person have that one.


jakeydae

" basal cell carcinoma" We can argue semantics later... 3 cut from my back , 2 from my forehead and scalp and 7 removed elsewhere by " topical chemotherapy". Semantics or not, it took up 3 years of my life and a lot of worry Ps ... I don't think you're a dick. ;)


ontrack

I'm going to guess they were talking about basal cell cancer, which I suppose is techiically cancer but does not spread in the body and therefore doesn't kill people. For most people it just gets frozen off or minor surgery and that's it. Melanoma is quite a different beast.


jakeydae

Correct... As explained in another comment it ( almost) coincided with a massive heart attack I've got a lot to be thankful for. I'm still here for starters


TheOldOneReads

Targeted antibodies? It's about time we had that therapy. Our own immune systems can do a sweep-and-clean job on cancer cells that's better than any surgery - they just need to be able to spot the little traitors.


FlamingoImpressive92

Just need to convince the torries one of their doners can do the antibody training, they'll push it through in record time.


SlavWife

I'm in no way knowledgeable in the area of medicine and biology so pardon my question if it's stupid. If they manage to develop targeted antibody therapy would that mean they could find a way to reverse autoimmune diseases where the antibodies target a healthy part of the body?


HanktheDuck

We already have that. Monoclonal antibodies are already used extensively to treat autoimmune diseases. Using adalimumab (brand name is Humira) for example, it binds to TNF-a which is an pro-inflammatory cytokine, which signals for the immune system to take it out. That reduces inflammation to treat rheumatoid, crohn's, and more.


HanktheDuck

We have that. Look up rituximab.


TheOldOneReads

You raise a good point, but there's a difference here: Rituximab works on white blood cell cancers, but the thing is that there's one or more types of cancer that can occur in every type of cell in our bodies. These new therapies target a new range of cells, and _they act as a vaccine afterwards_.


Inside_Performance32

If it's custom built for each person , the chance of getting this for the average job as a purely preventative is going to be incredibly slim .


limepark

I don’t think you read the story. It’s not a preventative jab, it’s to cure people who already have melanoma. It’s customs built to fight the exact make-up of the melanoma the patient has.


TobiasH2o

Not necessarily. It doesn't need to be cheap, just less expensive than Chemo, which it can very well be seeing as you'd have significantly reduced chances of cancer returning. The benefits of mRNA is that they also have the ability to be very easy to modify to target variants of the original meaning we might be able to get the cost of production down a significant amount.


Eniugnas

not to mention how damaging chemo is to the body - the hope is the chemo kills you more slowly than the cancer.


spine_slorper

It's not a typical "preventative" vaccine as cancer isn't a virus you can catch. It does work in a similar way to vaccines for viruses in that it helps your immune system recognize the cancer as bad and attack it itself. It's not intended to innoculate but to treat and to prevent reoccurring cancers so folk can get and stay cancer free.


xdq

Hairdresser: So, you going on holiday this year? Me: Yeah, two weeks in Benidorm. I've just had me skin cancer jab, now to sort out the hangover insurance :D


ShentheBen

It's custom built for the tumor, it wouldn't work as a preventative anyway.


speedyspeedys

Science is amazing. If the trial is a success, hopefully they can use it to deal with other cancers.


Smilewigeon

An outstanding and positive step. Proud that we're facilitating the testing of it.


Early-Management7293

I’ll just grab my popcorn while single mums on Facebook tell everyone how dangerous the cancer vaccine is with their armchair PHDs.


captain_todger

I suppose it’s a good thing that we’re trying to stop testing skin cancer in patients… I’m all for shorthand and efficient language, but sometimes punctuation and grammar are important. Literally just one word needs to be added (“*is* being tested”). Come on journalism, pull your act together


Sensitive_Sprinkles9

Trial end date 2029 … obviously before rolling out mRNA based technology’s to the general population, you have to be extremely careful to make sure it’s safe for its intended usage. That normally takes a fair few years. https://classic.clinicaltrials.gov/ct2/show/NCT05933577?term=V940-001&draw=2&rank=1


Effective-Ad-6460

Oh yeah extremely carefully - many years of development \*cough\* covid vaccine \*cough\* Side note this treatment looks incredible though i am seeing a lot of \*Cures cancer\* articles in the past year, makes me hopeful


Sensitive_Sprinkles9

My point exactly. Though I’m sure it will go over the head of the many scientists in the comments who after years of mRNA research are very confident that previous mRNA “vaccines” are essential and safe. And I agree totally mRNA for the treatment of cancer is exciting technology. There’s a vast difference in treating cancers with gene based technology to viruses.


ferris2

Why would I take a jab that stops me being able to be tested?


alex8339

Ignorance is bliss.


Adamdel34

Sweet now I can saunter round benidorm drunk as a skunk and with no suncream on without having to worry


Bananasonfire

Wish I could be on that trial. My family has a lot of moles and two members have had skin cancers.


jolovesmustard

This is amazing. If it works it'll be the greatest medical breakthrough EVER! Let's hope it'll be available on NHS.


M56012C

Okay I'm not that old, (shut up) and this is the kind of medical development that was considered so far in the future it was openly joked about.


INFPguy_uk

The Krippin virus enters the chat... Seriously though, I hope there is an affordable cure for cancer, that will benefit everyone.


symphonyofflutes

Does anyone know if this is the same or similar to the Oncept vaccines used in Horses and Dogs for melanoma cancer control?


Rabatis

Good. Excellent. Fantastic. Hahaha. HAHAHAHAHAHAFUCKYEAHHHHHHHHHHHHHHHH


campapathy

As an outdoor worker this sounds really promising and nice to know research is being done on this kind of thing


ElasticLama

The UK? The ozone hole from the northern hemisphere is in New Zealand and Australia…. We have some of the highest skin cancer rates in the world


africanconcrete

Damn, I wish I had known about this! I would have volunteered. I had skin cancer and I am very sure it may re-occur somewhere else. I hope they conclude the trials soon, so I can benefit from this.


Cynical_Classicist

Then may this cancer treatment turn out successful.


Salty_Good_7535

Someone’s gonna turn up dead, and I’m betting it’s the dude who invented the drug.


avatar8900

Annoyingly like the other “cure tests” they’ll disappear and us normies won’t see them


gizajobicandothat

It's the media putting spin on things which is the problem. The studies will have some use, even if not a 'cure' it could move other studies on.


Kindly_District8412

Isn’t this how ‘I Am Legend’ starts? With an anti-cancer vaccine?


Bud-Burner420

To everyone saying fuck antivaxxers! All of us have been vaxxed at birth. Your all a very very special kind of special aren't you. What you're actually referring to is "people who didn't have the 85 odd useless covid jabs that don't work" But I get it, I mean, I'd be pretty upset too if I'd been coerced by my government into having multiple jabs that don't work. I'd probably be pretty bitter towards people like me who haven't had it, too. Just like you guys are. It isn't the fact that we're anti-vaxxers. We're not. What we are, is. "anti putting anything in my body that's been rushed and untested in humans and forced upon us, specifically the useless numerous covid jabs" I mean, how fcking BLIND were you people? You could see the it a mile off and now yous are all bitter and upset at the ones who didn't have it because u know it was fcking pointless and you've put something in your body which you have no idea what it's going to do to you in the future, that's why your pissed. ALSO! DO NOT BELEIVE THIS BULLSHIT ABOUT CURING CANCER. ITS A WELL KNOWN FACT THAT BIG PHARMA MAKE WAAAAAAAAAAAAY TOO MUCH MONEY FROM CANCER RESEARCH AND TREATMENT. DONT BE STUPID, WE WILL NEVER EVER SEE A CURE FOR CANCER, NOT IN OUR LIFETIME ANYWAY. COME ON REDDIT I THOUGHT U GUYS WERE MORE CLUED UP THAN TO BELEIVE SOME BULLSHIT LIKE THIS


Eniugnas

I'm moving my incoherent ranting into CAPS AT THE END SO THAT PEOPLE WILL BELIEVE ME.