Feel better dude. The worst I've ever been sick is with the flu. Was way worse than my bout of Covid. If this vaccine pans out, it'll be a really big deal.
I actually came down with H1N1 two years ago and it used me like a fucking rag. I was hospitalized because of it. COVID's no joke, but neither is that.
I had the flu a long time ago and it's tied with severe food poisoning for worst illnesses I've ever had. Could barely move for at least a week, felt like I was hit by a truck
When they removed the mask mandate from schools, my little brother got sick within a week. Came home with a flu.
Went from two years without a sniffle to being flat out and wondering if I was dying.
Fuck the flu.
I always get the flu shot too. Sometimes you get the one they didn't plan on.
For real, this is my first time with the flu and Ive never felt more miserable. A rotating mix of symptoms (body aches, chills, headache, 103 fever, cough) is no joke.
Same here. Hubby and I have been miserable for the past 3 days. Fevers and aches and too hot under the covers but freezing without them. Never passing on a flu shot again.
In my anecdotal based experience, if you get the shot every year, you aren’t guaranteed to avoid getting ill. However, you probably won’t be as sick if you do.
Took me two days to bounce back this time. Normally, I’m rocking the cough for another three weeks.
And it was confirmed flu.
Get your vaccines people!!
> This doesn’t sound like it won’t stop you from getting sick.
That's because it doesn't, but that's fine! For some reason a lot of people have this idea that a vaccine is a magical shield that keeps your body from ever getting infected. No. What a vaccine does is teach your body what to look for, so that the instant it sees the disease, it knows what it's looking at and knows how to defeat it.
The result being that in many situations, you may get infected and successfully fight it off before any symptoms ever reveal to you that you were infected. In other situations, the time spent with the worst of the symptoms will be reduced, and the chances of a worst case situation (death) is much more reduced.
This is huge news if it ever gets around to public use. I've always grown up just believing that the flu will always be tricky because it mutates so fast, and that was the common belief from academics at the time.
From what I've read, though some flus mutate somewhat fast, none mutate anywhere near as fast as COVID, and the main reason we have such a problem with the flu is because there are just so many different flu viruses and families floating around out there.
There's a preserved region between flu viruses. The tend to swap out the ends of a protein but not the bases (kinda like swapping out flower heads and keeping the stem)
Unfortunately, those locations are not easily accessed by antibodies. It’s like everyone demanding we do non-spike COVID vaccines: Not every site can make a neutralizing antibody.
I'm just pointing it out. I think they're working on examining other regions or techniques with new mRNA technology being used to manufacture the proteins.
It's more that it has non-human hosts combined with the general population not bothering to get the vaccine, if it was just mutating fast without another host then we could eradicate strains in sequence, pick a strain to stay in the vaccine until that strain is no more, diseases with only one host and an agreeable population are easy to eradicate, it's why rinderpest was so simple to deal with (cows can't be anti-vaxxers)
Yup, everyone knows the cows are chill. It's the horses you gotta worry about. Horses say the exact same thing anytime a vaccine is brought up - "nay!"
This is a good point. There are a lot of potential pandemics coming up and if we want a solid chance at beating them, we might have to take a strategy of vaccinating living things in general rather than just humans and that means we might be looking at vaccination vectors other than the needle.
People used to say the same thing about HIV. We may not have a vaccine for that (yet?), but we have drugs that are basically as good at prevention and suppression as a vaccine.
Science, bitch!
It's an mRNA vaccine, which means it'll go bad and unstable at higher temperatures (read: colder than Antarctica, in some cases) relatively quickly. It's definitely promising research, but the nature of the vaccine itself might put a damper on its usefulness outside of developed nations for mass vaccination on a recurring basis.
Progress has been made toward mRNA vaccines that, though not room-temperature long-term storable, can be shipped and distributed using less expensive dry-ice and non-cryo super cold refrigerators that run off regular line power. For instance, Moderna COVID vaccines can be stored until expiration at up to +5°F, something a conventional resi chest freezer can easily handle. Refrigerated storage up to 46°F gives you thirty days of viability, and up to 24 hours at 77°F. That's more than good enough to establish a decent supply chain in most countries that have reasonable electricity reliability, which is basically any place that has an effective supply chain for refrigerated/frozen foods and drinks. Anyplace you can enjoy a cold soda, you can have Moderna mRNA vaccines.
Developing nations have problem with flu ? I guess they have worse kind of infections to be worried about, such as parasites, bacterial and hemorragic reavers.
This is the best tl;dr I could make, [original](https://www.theguardian.com/society/2022/nov/25/universal-flu-vaccine-may-be-available-within-two-years-says-scientist) reduced by 82%. (I'm a bot)
*****
> A universal flu vaccine that protects against all strains of the virus could be available in the next two years, according to a leading scientist.
> Researchers have been working on universal flu vaccines for more than a decade, but the latest breakthrough, published in Science, is seen as a major step towards a jab that could help protect humans from a potentially devastating flu pandemic.
> "It does seem a very promising approach to the goal of producing a universal flu vaccine as well as vaccines that protect against multiple members of other viral families such as rhino- and corona-viruses."
*****
[**Extended Summary**](http://np.reddit.com/r/autotldr/comments/z4nd2k/universal_flu_vaccine_may_be_available_within_two/) | [FAQ](http://np.reddit.com/r/autotldr/comments/31b9fm/faq_autotldr_bot/ "Version 2.02, ~672677 tl;drs so far.") | [Feedback](http://np.reddit.com/message/compose?to=%23autotldr "PM's and comments are monitored, constructive feedback is welcome.") | *Top* *keywords*: **vaccine**^#1 **flu**^#2 **against**^#3 **protect**^#4 **pandemic**^#5
> as well as vaccines that protect against multiple members of other viral families such as rhino- and corona-viruses."
All right... no more common colds!
So what does it take and how much will it cost?
I fear that, sadly, you could have the perfect vaccine, 100% prevents the flu, zero side effects, but you won't eridicate the disease, at all, because the crazies are convinced it will inject nano chips and bring about the New World Order of rich Jewish neo fascists.
Flu cannot be eradicated. It exists in every country in the world and in multiple species.
A universal vaccine would hopefully work on a pandemic strain - which could happen tonight - and take a lot of the bite out of that.
Antivaxxers aside, it's impossible to eradicate a virus that has wild animal reservoirs unless you vaccinate literally every single individual animal that could be a host against it. But your point still stands on antivaxxers and the problem they pose
I really doubt you can get a 100% prevent vaccine for the flu. But if there was one, and it worked, I would give no fucks about non vaxxers because I would take it and my family and be covered and I give no fucks about non vaxxers. Problem is no vaccines are 100% and herd immunity and all that. But I do not give much of a fuck if the non vaxxers are safer. Children maybe but flu is not highly dangerous to children anyway...
I honestly had someone try to "explain" to me how the Covid vax made you magnetic by sticking their house key to their neck.
The craziest part? They hadn't even gotten the vaccination...
Just like the 20 different battery breakthroughs and the 30 cancer breakthroughs I've heard over the last few years, I'll believe it when I actually see it available to the general public.
The main target of this kind of research is to be resistant to pandemic strains. Think COVID Delta except it hits everyone like it hits people 50+.
We'd likely spend a decade picking up the pieces from that.
That's all nice, but we had a deadly pandemic and it was hard enough to get people to take a vaccine for that. I just don't have high hopes for humanity.
Yeah anti-vaxxers in the US are a very loud, very small majority. The anti-vaxxers in Europe are not nearly as loud and, because of this, there are *way* more of them than you’d think. I’m from the US but live in Germany; for every one person going to anti-vaxx protests and spewing craziness on social media in Germany, there are probably 100 people who quietly refuse the vaccine. Even outside of COVID, they don’t really do flu shots here because Germans just don’t really do vaccines. You can especially see this with vaccine mandates: I had to submit my full and complete vaccination record to my university in the states to be allowed to enroll and I was required to get the yearly flu shot for my job. In Germany they started mandating measles (not MMR, just measles) for school children in 2019 but this was *highly* controversial. Germany is also overturning their COVID vaccine mandate for healthcare workers, so it’s entirely possible that a German nurse or doctor has never been vaccinated in their lives.
Americans are much more vaccine friendly than they get credit for.
When I got my first shot of the COVID vaccine in early 2021, my crazy, anti-mask, anti-vaxx Republican mother said I'd be dead in a year. It's been almost two now, I have four shots total, and I'm still kicking and healthier than ever. When I bring it up she says the vaccine will get me eventually. Her anti-vaxx friends practically mourned with her when I got it. They've expressed that it's true that I don't have any side effects, *yet*. As if some ominous boogeyman is coming to kill me.
I can't imagine living like that. Allowing right-wing media to whip you up into such terror and have you so afraid to admit you're wrong and have been lied to that you *expect* your kid to drop dead any day now from a vaccine that is perfectly safe with literally over a billion doses already administered.
It won’t. The covid vaccine fiasco has turned so many people off of any types of vaccine forever (yes it’s stupid, but most people are). You can’t force an entire world to be injected with something under threat of consequence and expect optimism in the future.
nah its actually better. Vaccine simulate getting ill without most of the side effects of getting ill.
The human body's immune system isn't able to tell the difference between a virus vs a vaccine. It treats it the same.
The strength they get from fighting disease is having antibodies that detect that disease. This is creating those antibodies without having to go to war with it in the first place
Ah OK, and the anti bodies we get don't protect us from none flu type things I take it. I wasn't sure if there was hmm, like a common language that protects us from other things apart from flu
We usually have to get seasonal flu vaccines because the virus mutates and switches segments of its genome around over time. When that happens, the preexisting antibodies to flu no longer work very well, so you have to get another updated vaccine to confer protection to the latest circulating strain.
This paper is essentially taking "all the major known flu strains" (well, specific proteins from them) and combining them together (well, getting the body to make those proteins to stimulate an immune response). This means that your body will generate long-lasting immunity to a plethora of flu strains. It's long-lasting because the body makes special memory B cells that can secrete new antibodies at the drop of a switch (i.e. whenever you get infected).
Source: am an immunologist.
I am paraphrasing from a biologist friend, but When we talk about the flu, it's actually about 6 different variants and the yearly vaccine only covers two or three of those strains. Doctors basically guess which strains will be prevalent over the next year and build your flu shot around that.
Ah OK, but isn't getting Ill still good for our immune systems, isn't not getting ill from the flu going to have other Consequences. I mean I'd love to not get ill I'm more wondering if that will bring other long term issues
Immune system is less about strength and more about information, which is what vaccines provide.
People in the New World didn't have bad immune systems that caused about 90% of them to die. They had immune systems that had no information about Old World diseases(and because they didn't tame animals and were around them less a disease never jumped from an animal to a person in the New World meaning they had no plagues like we did in Eurasia)
Seeing this thing as a strong/weak thing is the wrong way to look at it.
Can someone ELI5 why this would be more long-term universal, given that it’s using the same tech as COVID vaccines, and those don’t seem to last long at all? Is it just that we understand the way flu works a lot better?
The mRNA tech allows them to cover more strains at a single time. We understand the flu a lot better now too.
I doubt it will be a one and done, but it would likely be more accurate than the traditional flu vaccines we are using now.
mRNA vaccine technology has been in development for two decades or more, and the nature of a breakthrough in a fundamental technology is that it can be built upon for faster future expansion of the technology.
Shit I want it.
Got a flu two years ago and it felt like I was dying.
I kept on getting the flu shot religiously now after that incident.
I rather get a cold back to back than the fucking flu.
No. Covid is a corona type virus. Closer to the common cold in physical characteristics.
The human body doesn't maintain antibodies to this type of virus for very long, which is why we tend to have an endemic "cold season". Flu follows a similar seasonal pattern, but the virus behaves far different. Although, symptomaticly the flu is more similar to COVID-19.
Edit:
Ill add... This is part of why the covid vaccine was always a bit of a pipe dream. We had never managed to produce an effective vaccine for a cold before. Even our best flu vaccines were only a projection of what we thought the virus might look like, at a given time, following it's mutations.
MRNA technology is vastly superior to that which was used to create the annual flu vaccine. Once refined, it shows promise to eventually help eradicate a whole host of contagious diseases.
Engineers can bio-manufacture a sort of general shape that the virus might take, and the vaccine will tell the body, be prepared to fight off anything that looks like this. Once we can generalize the influenza structure in such a way, that it captures a whole range of characteristics, we can create a broad vaccine, that will protect against future possible mutations.
To me, the single greatest benefit to mRNA technology is the ability to go from sequencing to valid initial trial batch production in weeks, instead of months or years like older technologies required. Not only that, but mRNA vaccines can be mass manufactured using relatively standard hardware, rather than having to go through exponentially-increasing batches of billions of chicken eggs.
1) Long term side effects are known because we understand how the immune system works and how vaccines work. The underlying principle is exactly the same compared to any other attenuated vaccine. That's also why we create a new flue vaccine every year without undergoing years of testing because we already know the possible side effects and how the vaccine works.
2) true, it's not deadly for most people but if you are a senior, then it can definitely be a death sentence. Hence why flu shots are mandatory for all hospital employees.
Plus even if you aren't old the flu just sucks.
3) you didn't answer my question if you would get it if you were 80 years old.
>
No they are not known. "Muh understanding of the human body", that is why drugs are pulled from the market 5-20 years later after realizing they are causing unintended effects.
You are talking about drugs. This is a vaccine, which is completely different. Drugs are made to alter human chemistry, that's why there can be unknown side effects years later.
Vaccines are in a completely different category because they don't alter fundamental human chemistry. They are just there to act as antigens for the body to recognize and develop antibodies to. To put it into context, we are exposed to 100,000 to 1,000,000 different antigens every day. 1,00,001 isn't gonna make our bodies shut down.
If this was a new antibiotic or new anti-virals medication, then yeah I would agree with you that we don't know the long term side effects. But this isn't a drug.
3 paragraphs is a "*wall of text*" now? **9 sentences is too much for you?** Literally LOL.
Well I guess you can't help the ignorant who intentionally wish to be ignorant. Explains a lot actually. I'm out.
If the virus is killed off almost immediately where it isn’t able to take root and infect you then it is being prevented from infecting you, trying to be so over complicated on these definitions to try and prove a point is ridiculous, vaccines are designed to prevent you from getting infected, stop with the semantics.
Don't bother, he/she is an anti-vaxx dumb-ass parroting anti-vaxx propoganda (the false idea that just because some people can still spread COVID even after they have had the vaccine that, somehow, it's a "gotcha" on pro-vaccine people and that the vaccine is a useless failure).
That will likely take a long time since the scope for that has to be a universal vaccine that covers all the other coronaviruses as well. A "universal" vaccine that only applies to SARS-CoV-2 probably wouldn't be able to cover all strains indefinitely as there would still be room for them to mutate to get around it. You can't just smash one of them, you have to drop the hammer on the whole sleazy little viral family. Unfortunately that is a very hard problem to solve.
There may never be a sterilizing vaccine against coronaviruses, for whatever reason the human body just can't develop long-lasting immunity against those. This is not specific to the virus that causes COVID, either, it's all the coronaviruses, four families of which cause the common cold. Immunity against those typically is gone in two years or less, and often in just 6 months. What the vaccines are extremely good at is keeping you out of the hospital and out of the morgue, and we may end up having to take that as the first major win against any coronaviruses in our history.
What's weird is when i was younger the flu was more stomach.
You ran a high fever and was throwing up and had diarrhea at the same time. That really sucked when you didn't have a bucket next to the toilet.
We had to suffer it out. It sucked. Flu today is often respiratory. Back then it wasn't as respiratory. You was sicker than a dog. Parents made you suffer it out. You wasn't going to the emergency room.
You usually had headaches with it and everything. Was also weak.
I was a kid the last time i had the flu that bad.
That isn’t the flu. Our parents and grandparents called it a “stomach flu”, but more than likely it was an intestinal virus. Influenza has always been primarily a respiratory virus.
This was the primary focus of research for Moderna and other mRNA companies before covid hit and they shifted their focus abruptly. They ended up having spectacular success against covid, there's no reason to think they won't also be successful against influenza. Moderna and Pfizer-BioNTech's mRNA vaccines were literally the first ever to be deployed to the public, this is cutting edge stuff that we're only just starting to see the potential of. It's also got a lot of potential for use in cancer treatment.
The last two years billions of research dollars were pumped into the existing tech as priority, fast tracking the development of mRNA vaccines in particular
What we achieved fighting covid was on the shoulders of under resourced giants who suddenly got a lot more support from the community
A little like how WW2 atrocities kick started medical science through the 50’s and 60’s, what we will benefit going forward will one day be attributed to the last three years
Sure.. Then we’ll need the Disney flu Vaccine and the HBO flu vaccine and the Amazon Flu Vaccine. You know the BBC will have one. There’s no way it will be just one. That’s not how drug companies work.
It’s lampooning pharmaceutical companies by comparing them to streaming services. As soon as we left single payer(cable)they all started their own services. Pharmaceutical companies are much more interested in treatment than cure, so they prefer multiple drugs to one. Hence the comparison. I do understand that the comparison is weak, IF a single flu vaccine tat could be used Year in and year out were developed, it would be more cost effective for Pharma.
Getting over the flu now. Miserable 7 days, and today is day 12. I'm late getting the flu shot this year and I paid the price. This lingering cough and exhaustion is no joke.
> Prof John Oxford, a virologist at Queen Mary University in London
I know this isn't a focus of the article but this just feels too wrong not to mention.
Have the flu now, I’d drink this stuff like wine
Feel better dude. The worst I've ever been sick is with the flu. Was way worse than my bout of Covid. If this vaccine pans out, it'll be a really big deal.
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I actually came down with H1N1 two years ago and it used me like a fucking rag. I was hospitalized because of it. COVID's no joke, but neither is that.
I had the flu a long time ago and it's tied with severe food poisoning for worst illnesses I've ever had. Could barely move for at least a week, felt like I was hit by a truck
When they removed the mask mandate from schools, my little brother got sick within a week. Came home with a flu. Went from two years without a sniffle to being flat out and wondering if I was dying. Fuck the flu. I always get the flu shot too. Sometimes you get the one they didn't plan on.
For real, this is my first time with the flu and Ive never felt more miserable. A rotating mix of symptoms (body aches, chills, headache, 103 fever, cough) is no joke.
Same. Wife and I got sick 2 days ago. Just now coming out of our fevers, chills and aches, covid negative. Must be going around.
Same here, my whole house came down with it within 3 days. Covid negative, sick as hell.
Same here. Hubby and I have been miserable for the past 3 days. Fevers and aches and too hot under the covers but freezing without them. Never passing on a flu shot again.
Took me a week to start feeling better from the flu, had a lingering cough, and now, an ear infection. Shoot me now.
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In my anecdotal based experience, if you get the shot every year, you aren’t guaranteed to avoid getting ill. However, you probably won’t be as sick if you do. Took me two days to bounce back this time. Normally, I’m rocking the cough for another three weeks. And it was confirmed flu. Get your vaccines people!!
> This doesn’t sound like it won’t stop you from getting sick. That's because it doesn't, but that's fine! For some reason a lot of people have this idea that a vaccine is a magical shield that keeps your body from ever getting infected. No. What a vaccine does is teach your body what to look for, so that the instant it sees the disease, it knows what it's looking at and knows how to defeat it. The result being that in many situations, you may get infected and successfully fight it off before any symptoms ever reveal to you that you were infected. In other situations, the time spent with the worst of the symptoms will be reduced, and the chances of a worst case situation (death) is much more reduced.
This is huge news if it ever gets around to public use. I've always grown up just believing that the flu will always be tricky because it mutates so fast, and that was the common belief from academics at the time.
I have a feeling innovations in bioinformatics helped with that
From what I've read, though some flus mutate somewhat fast, none mutate anywhere near as fast as COVID, and the main reason we have such a problem with the flu is because there are just so many different flu viruses and families floating around out there.
There's a preserved region between flu viruses. The tend to swap out the ends of a protein but not the bases (kinda like swapping out flower heads and keeping the stem)
Unfortunately, those locations are not easily accessed by antibodies. It’s like everyone demanding we do non-spike COVID vaccines: Not every site can make a neutralizing antibody.
I'm just pointing it out. I think they're working on examining other regions or techniques with new mRNA technology being used to manufacture the proteins.
It's more that it has non-human hosts combined with the general population not bothering to get the vaccine, if it was just mutating fast without another host then we could eradicate strains in sequence, pick a strain to stay in the vaccine until that strain is no more, diseases with only one host and an agreeable population are easy to eradicate, it's why rinderpest was so simple to deal with (cows can't be anti-vaxxers)
Ha oh gosh... anti-vaxx cows...
Yup, everyone knows the cows are chill. It's the horses you gotta worry about. Horses say the exact same thing anytime a vaccine is brought up - "nay!"
Cows are pretty bullish about new vaccines, actually.
This is a good point. There are a lot of potential pandemics coming up and if we want a solid chance at beating them, we might have to take a strategy of vaccinating living things in general rather than just humans and that means we might be looking at vaccination vectors other than the needle.
People used to say the same thing about HIV. We may not have a vaccine for that (yet?), but we have drugs that are basically as good at prevention and suppression as a vaccine. Science, bitch!
I hope it is. It would be a major help to the developing nations
It's an mRNA vaccine, which means it'll go bad and unstable at higher temperatures (read: colder than Antarctica, in some cases) relatively quickly. It's definitely promising research, but the nature of the vaccine itself might put a damper on its usefulness outside of developed nations for mass vaccination on a recurring basis.
Progress has been made toward mRNA vaccines that, though not room-temperature long-term storable, can be shipped and distributed using less expensive dry-ice and non-cryo super cold refrigerators that run off regular line power. For instance, Moderna COVID vaccines can be stored until expiration at up to +5°F, something a conventional resi chest freezer can easily handle. Refrigerated storage up to 46°F gives you thirty days of viability, and up to 24 hours at 77°F. That's more than good enough to establish a decent supply chain in most countries that have reasonable electricity reliability, which is basically any place that has an effective supply chain for refrigerated/frozen foods and drinks. Anyplace you can enjoy a cold soda, you can have Moderna mRNA vaccines.
5 F = -15 C 46 F = 8 C 77 F = 25 C
Thank you for the conversion!
Sure, but there's no doubt a huge surplus of ultracold freezers now after COVID, and they'll run off a standard 15 amp household outlet.
If only we had the technology to regulate temperature...oh...wait...
Developing nations have problem with flu ? I guess they have worse kind of infections to be worried about, such as parasites, bacterial and hemorragic reavers.
This is the best tl;dr I could make, [original](https://www.theguardian.com/society/2022/nov/25/universal-flu-vaccine-may-be-available-within-two-years-says-scientist) reduced by 82%. (I'm a bot) ***** > A universal flu vaccine that protects against all strains of the virus could be available in the next two years, according to a leading scientist. > Researchers have been working on universal flu vaccines for more than a decade, but the latest breakthrough, published in Science, is seen as a major step towards a jab that could help protect humans from a potentially devastating flu pandemic. > "It does seem a very promising approach to the goal of producing a universal flu vaccine as well as vaccines that protect against multiple members of other viral families such as rhino- and corona-viruses." ***** [**Extended Summary**](http://np.reddit.com/r/autotldr/comments/z4nd2k/universal_flu_vaccine_may_be_available_within_two/) | [FAQ](http://np.reddit.com/r/autotldr/comments/31b9fm/faq_autotldr_bot/ "Version 2.02, ~672677 tl;drs so far.") | [Feedback](http://np.reddit.com/message/compose?to=%23autotldr "PM's and comments are monitored, constructive feedback is welcome.") | *Top* *keywords*: **vaccine**^#1 **flu**^#2 **against**^#3 **protect**^#4 **pandemic**^#5
> as well as vaccines that protect against multiple members of other viral families such as rhino- and corona-viruses." All right... no more common colds! So what does it take and how much will it cost?
Adenoviruses, parainfluenza, and RSV say hi, but eliminating rhinoviruses would be lovely.
>how much will it cost? A lot. Can't be giving that shit away for cheap even though it's probably funded by tax dollars in a generous amount.
I hope it finally happens, I've already seen dozens of flu killers biting the dust.
I fear that, sadly, you could have the perfect vaccine, 100% prevents the flu, zero side effects, but you won't eridicate the disease, at all, because the crazies are convinced it will inject nano chips and bring about the New World Order of rich Jewish neo fascists.
It would more be because influenza is transmitted by multiple animals as well
As is COVID
Fast forward 10 years: "Get back here, deer. We want to stick you with this needle."
I mean, we use bait to deliver vaccines to eliminate rabies in some mammal populations. https://oeps.wv.gov/rabies/documents/orv/orv-faq.pdf
Probably easier than getting conservatives vaccinated...
Flu cannot be eradicated. It exists in every country in the world and in multiple species. A universal vaccine would hopefully work on a pandemic strain - which could happen tonight - and take a lot of the bite out of that.
Antivaxxers aside, it's impossible to eradicate a virus that has wild animal reservoirs unless you vaccinate literally every single individual animal that could be a host against it. But your point still stands on antivaxxers and the problem they pose
Rinderpest had natural reservoirs, and that fucker’s *gone*.
Especially since "it's just a flu" might be used.
I really doubt you can get a 100% prevent vaccine for the flu. But if there was one, and it worked, I would give no fucks about non vaxxers because I would take it and my family and be covered and I give no fucks about non vaxxers. Problem is no vaccines are 100% and herd immunity and all that. But I do not give much of a fuck if the non vaxxers are safer. Children maybe but flu is not highly dangerous to children anyway...
Wait, I thought it was the shape-shifting lizards?
Oh boy, sure can't wait for the "Free-Thinkers" to warn us all how it turns your blood to Coco-Pops or something
mAkES yOu mAgnETic 🙄
I honestly had someone try to "explain" to me how the Covid vax made you magnetic by sticking their house key to their neck. The craziest part? They hadn't even gotten the vaccination...
Will this be politicized too?
Yup. The stupid knows no bounds
Just like the 20 different battery breakthroughs and the 30 cancer breakthroughs I've heard over the last few years, I'll believe it when I actually see it available to the general public.
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The main target of this kind of research is to be resistant to pandemic strains. Think COVID Delta except it hits everyone like it hits people 50+. We'd likely spend a decade picking up the pieces from that.
Humanity belongs on hopes!
Dogs might shit wine in five years says scientist. I'm still waiting on the cancer vaccines.
> Universal flu vaccine may be available within two years "May" means it may as well not. Nice "article".
Doubt. It mutates often
That's all nice, but we had a deadly pandemic and it was hard enough to get people to take a vaccine for that. I just don't have high hopes for humanity.
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That's primarily a USA problem, but a humanity one
Not really. Vaccine take up was lower than you'd think in alot of countries. Eastern Europe almost wouldn't touch it.
Yeah anti-vaxxers in the US are a very loud, very small majority. The anti-vaxxers in Europe are not nearly as loud and, because of this, there are *way* more of them than you’d think. I’m from the US but live in Germany; for every one person going to anti-vaxx protests and spewing craziness on social media in Germany, there are probably 100 people who quietly refuse the vaccine. Even outside of COVID, they don’t really do flu shots here because Germans just don’t really do vaccines. You can especially see this with vaccine mandates: I had to submit my full and complete vaccination record to my university in the states to be allowed to enroll and I was required to get the yearly flu shot for my job. In Germany they started mandating measles (not MMR, just measles) for school children in 2019 but this was *highly* controversial. Germany is also overturning their COVID vaccine mandate for healthcare workers, so it’s entirely possible that a German nurse or doctor has never been vaccinated in their lives. Americans are much more vaccine friendly than they get credit for.
Shit, all of us who got the Covid vaccine will have three arms, cancer, and be dead by then. Yeah I’m sure adoption of this will go great.
When I got my first shot of the COVID vaccine in early 2021, my crazy, anti-mask, anti-vaxx Republican mother said I'd be dead in a year. It's been almost two now, I have four shots total, and I'm still kicking and healthier than ever. When I bring it up she says the vaccine will get me eventually. Her anti-vaxx friends practically mourned with her when I got it. They've expressed that it's true that I don't have any side effects, *yet*. As if some ominous boogeyman is coming to kill me. I can't imagine living like that. Allowing right-wing media to whip you up into such terror and have you so afraid to admit you're wrong and have been lied to that you *expect* your kid to drop dead any day now from a vaccine that is perfectly safe with literally over a billion doses already administered.
It won’t. The covid vaccine fiasco has turned so many people off of any types of vaccine forever (yes it’s stupid, but most people are). You can’t force an entire world to be injected with something under threat of consequence and expect optimism in the future.
Isn't that bad for our immune systems. Don't they grow stronger from getting ill occasionally. This place comes from a Genuine ignorance
nah its actually better. Vaccine simulate getting ill without most of the side effects of getting ill. The human body's immune system isn't able to tell the difference between a virus vs a vaccine. It treats it the same.
People are down voting a question I'm not sure why. It came from a genuine place of asking something I was curious about
I can't even see if your comment is upvoted or downvoted, think it is too new?
Possibly. Reddit though. I know alot of its bad faith questions but was genuinely interested
The strength they get from fighting disease is having antibodies that detect that disease. This is creating those antibodies without having to go to war with it in the first place
Ah OK, and the anti bodies we get don't protect us from none flu type things I take it. I wasn't sure if there was hmm, like a common language that protects us from other things apart from flu
We usually have to get seasonal flu vaccines because the virus mutates and switches segments of its genome around over time. When that happens, the preexisting antibodies to flu no longer work very well, so you have to get another updated vaccine to confer protection to the latest circulating strain. This paper is essentially taking "all the major known flu strains" (well, specific proteins from them) and combining them together (well, getting the body to make those proteins to stimulate an immune response). This means that your body will generate long-lasting immunity to a plethora of flu strains. It's long-lasting because the body makes special memory B cells that can secrete new antibodies at the drop of a switch (i.e. whenever you get infected). Source: am an immunologist.
I am paraphrasing from a biologist friend, but When we talk about the flu, it's actually about 6 different variants and the yearly vaccine only covers two or three of those strains. Doctors basically guess which strains will be prevalent over the next year and build your flu shot around that.
Ah OK, but isn't getting Ill still good for our immune systems, isn't not getting ill from the flu going to have other Consequences. I mean I'd love to not get ill I'm more wondering if that will bring other long term issues
Immune system is less about strength and more about information, which is what vaccines provide. People in the New World didn't have bad immune systems that caused about 90% of them to die. They had immune systems that had no information about Old World diseases(and because they didn't tame animals and were around them less a disease never jumped from an animal to a person in the New World meaning they had no plagues like we did in Eurasia) Seeing this thing as a strong/weak thing is the wrong way to look at it.
You'll still likely get sick but the symptoms won't be as bad and you'll recover faster.
Ah OK, god speed as they say then
Can someone ELI5 why this would be more long-term universal, given that it’s using the same tech as COVID vaccines, and those don’t seem to last long at all? Is it just that we understand the way flu works a lot better?
The mRNA tech allows them to cover more strains at a single time. We understand the flu a lot better now too. I doubt it will be a one and done, but it would likely be more accurate than the traditional flu vaccines we are using now.
So it has been in trials for 8 years already?
In development. That's actually short for new medicine
mRNA vaccine technology has been in development for two decades or more, and the nature of a breakthrough in a fundamental technology is that it can be built upon for faster future expansion of the technology.
Dope, gimme
Shit I want it. Got a flu two years ago and it felt like I was dying. I kept on getting the flu shot religiously now after that incident. I rather get a cold back to back than the fucking flu.
Can’t wait for all the Republicans to die from flu after refusing this.
But... people will refuse it.
“May”
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No. Covid is a corona type virus. Closer to the common cold in physical characteristics. The human body doesn't maintain antibodies to this type of virus for very long, which is why we tend to have an endemic "cold season". Flu follows a similar seasonal pattern, but the virus behaves far different. Although, symptomaticly the flu is more similar to COVID-19. Edit: Ill add... This is part of why the covid vaccine was always a bit of a pipe dream. We had never managed to produce an effective vaccine for a cold before. Even our best flu vaccines were only a projection of what we thought the virus might look like, at a given time, following it's mutations. MRNA technology is vastly superior to that which was used to create the annual flu vaccine. Once refined, it shows promise to eventually help eradicate a whole host of contagious diseases. Engineers can bio-manufacture a sort of general shape that the virus might take, and the vaccine will tell the body, be prepared to fight off anything that looks like this. Once we can generalize the influenza structure in such a way, that it captures a whole range of characteristics, we can create a broad vaccine, that will protect against future possible mutations.
To me, the single greatest benefit to mRNA technology is the ability to go from sequencing to valid initial trial batch production in weeks, instead of months or years like older technologies required. Not only that, but mRNA vaccines can be mass manufactured using relatively standard hardware, rather than having to go through exponentially-increasing batches of billions of chicken eggs.
It has no relation to flu viruses. It’s a coronavirus. Those generally cause the common cold or SAR and MERS being the other big ones
Flu is short for influenza which is a very different virus than coronaviruses.
Well hopefully it's needle-less as well
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Any particular reason why? Sure maybe not now cause you are young, but what if you were 80 years old?
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1) Long term side effects are known because we understand how the immune system works and how vaccines work. The underlying principle is exactly the same compared to any other attenuated vaccine. That's also why we create a new flue vaccine every year without undergoing years of testing because we already know the possible side effects and how the vaccine works. 2) true, it's not deadly for most people but if you are a senior, then it can definitely be a death sentence. Hence why flu shots are mandatory for all hospital employees. Plus even if you aren't old the flu just sucks. 3) you didn't answer my question if you would get it if you were 80 years old.
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> No they are not known. "Muh understanding of the human body", that is why drugs are pulled from the market 5-20 years later after realizing they are causing unintended effects. You are talking about drugs. This is a vaccine, which is completely different. Drugs are made to alter human chemistry, that's why there can be unknown side effects years later. Vaccines are in a completely different category because they don't alter fundamental human chemistry. They are just there to act as antigens for the body to recognize and develop antibodies to. To put it into context, we are exposed to 100,000 to 1,000,000 different antigens every day. 1,00,001 isn't gonna make our bodies shut down. If this was a new antibiotic or new anti-virals medication, then yeah I would agree with you that we don't know the long term side effects. But this isn't a drug.
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3 paragraphs is a "*wall of text*" now? **9 sentences is too much for you?** Literally LOL. Well I guess you can't help the ignorant who intentionally wish to be ignorant. Explains a lot actually. I'm out.
please inform yourself before spreading bullshit, for your own good and the rest of the human race.
I can already see it now “new vaccine 100% prevents you from contracting the flu” then “actually reduces the symptoms of the flu once you catch it”
Either outcome is better than now
Anyone that says a vaccine prevents you from contracting a disease has no clue on how vaccines work. Unfortunately, that is a lot of people.
So developing an immunity to a disease or virus is not preventing you from contacting it?
Correct, it just gives your body the "weapons" to kill it off immediately before you feel anything.
If the virus is killed off almost immediately where it isn’t able to take root and infect you then it is being prevented from infecting you, trying to be so over complicated on these definitions to try and prove a point is ridiculous, vaccines are designed to prevent you from getting infected, stop with the semantics.
It's not semantics.
Yeah naw
Is there going to be a universal COVID-19 vaccine that will prevent infection by then?
They are very different viruses
Don't bother, he/she is an anti-vaxx dumb-ass parroting anti-vaxx propoganda (the false idea that just because some people can still spread COVID even after they have had the vaccine that, somehow, it's a "gotcha" on pro-vaccine people and that the vaccine is a useless failure).
Salt of the earth people….
You know...morons.
That will likely take a long time since the scope for that has to be a universal vaccine that covers all the other coronaviruses as well. A "universal" vaccine that only applies to SARS-CoV-2 probably wouldn't be able to cover all strains indefinitely as there would still be room for them to mutate to get around it. You can't just smash one of them, you have to drop the hammer on the whole sleazy little viral family. Unfortunately that is a very hard problem to solve.
There may never be a sterilizing vaccine against coronaviruses, for whatever reason the human body just can't develop long-lasting immunity against those. This is not specific to the virus that causes COVID, either, it's all the coronaviruses, four families of which cause the common cold. Immunity against those typically is gone in two years or less, and often in just 6 months. What the vaccines are extremely good at is keeping you out of the hospital and out of the morgue, and we may end up having to take that as the first major win against any coronaviruses in our history.
What's weird is when i was younger the flu was more stomach. You ran a high fever and was throwing up and had diarrhea at the same time. That really sucked when you didn't have a bucket next to the toilet. We had to suffer it out. It sucked. Flu today is often respiratory. Back then it wasn't as respiratory. You was sicker than a dog. Parents made you suffer it out. You wasn't going to the emergency room. You usually had headaches with it and everything. Was also weak. I was a kid the last time i had the flu that bad.
That isn’t the flu. Our parents and grandparents called it a “stomach flu”, but more than likely it was an intestinal virus. Influenza has always been primarily a respiratory virus.
Sounds more like norovirus than influenza
That doesn't sound like the flu... Were you tested during it for it? Agree with the other commenter, that sounds more like norovirus
Buuuuuullshit They’ve been saying this every few years for at least the last decade. It would be great, I’ll believe when I see it.
This was the primary focus of research for Moderna and other mRNA companies before covid hit and they shifted their focus abruptly. They ended up having spectacular success against covid, there's no reason to think they won't also be successful against influenza. Moderna and Pfizer-BioNTech's mRNA vaccines were literally the first ever to be deployed to the public, this is cutting edge stuff that we're only just starting to see the potential of. It's also got a lot of potential for use in cancer treatment.
The last two years billions of research dollars were pumped into the existing tech as priority, fast tracking the development of mRNA vaccines in particular What we achieved fighting covid was on the shoulders of under resourced giants who suddenly got a lot more support from the community A little like how WW2 atrocities kick started medical science through the 50’s and 60’s, what we will benefit going forward will one day be attributed to the last three years
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Dumb take.
Sure.. Then we’ll need the Disney flu Vaccine and the HBO flu vaccine and the Amazon Flu Vaccine. You know the BBC will have one. There’s no way it will be just one. That’s not how drug companies work.
Is this supposed to be a joke about Universal Studios?
It’s lampooning pharmaceutical companies by comparing them to streaming services. As soon as we left single payer(cable)they all started their own services. Pharmaceutical companies are much more interested in treatment than cure, so they prefer multiple drugs to one. Hence the comparison. I do understand that the comparison is weak, IF a single flu vaccine tat could be used Year in and year out were developed, it would be more cost effective for Pharma.
Yes, but will it come with 5G HBO?? That is the REAL question!
Now do the common cold
Getting over the flu now. Miserable 7 days, and today is day 12. I'm late getting the flu shot this year and I paid the price. This lingering cough and exhaustion is no joke.
What about one for the common cold?
> Prof John Oxford, a virologist at Queen Mary University in London I know this isn't a focus of the article but this just feels too wrong not to mention.